A Comprehensive Study of Drug Loading in Hollow Mesoporous Silica Nanoparticles: Impacting Factors and Loading Efficiency
Although hollow mesoporous silica nanoparticles (HMSNs) have been intensively studied as nanocarriers, selecting the right HMSNs for specific drugs still remains challenging due to the enormous diversity in so far reported HMSNs and drugs. To this end, we herein made a comprehensive study on drug lo...
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MDPI AG
2021-05-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/5/1293 |
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| author | Lanying Guo Jiantao Ping Jinglei Qin Mu Yang Xi Wu Mei You Fangtian You Hongshang Peng |
| author_facet | Lanying Guo Jiantao Ping Jinglei Qin Mu Yang Xi Wu Mei You Fangtian You Hongshang Peng |
| author_sort | Lanying Guo |
| collection | DOAJ |
| description | Although hollow mesoporous silica nanoparticles (HMSNs) have been intensively studied as nanocarriers, selecting the right HMSNs for specific drugs still remains challenging due to the enormous diversity in so far reported HMSNs and drugs. To this end, we herein made a comprehensive study on drug loading in HMSNs from the viewpoint of impacting factors and loading efficiency. Specifically, two types of HMSNs with negative and positive zeta potential were delicately constructed, and three categories of drugs were selected as delivery targets: highly hydrophobic and lipophobic (oily), hydrophobic, and hydrophilic. The results indicated that (i) oily drugs could be efficiently loaded into both of the two HMSNs, (ii) HMSNs were not good carriers for hydrophobic drugs, especially for planar drugs, (iii) HMSNs had high loading efficiency towards oppositely charged hydrophilic drugs, i.e., negatively charged HMSNs for cationic molecules and vice versa, (iv) entrapped drugs would alter zeta potential of drug-loaded HMSNs. This work may provide general guidelines about designing high-payload HMSNs by reference to the physicochemical property of drugs. |
| first_indexed | 2024-03-10T10:49:06Z |
| format | Article |
| id | doaj.art-b65bd553386f4ec9b77d43fcde3e73dd |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T10:49:06Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-b65bd553386f4ec9b77d43fcde3e73dd2023-11-21T22:21:16ZengMDPI AGNanomaterials2079-49912021-05-01115129310.3390/nano11051293A Comprehensive Study of Drug Loading in Hollow Mesoporous Silica Nanoparticles: Impacting Factors and Loading EfficiencyLanying Guo0Jiantao Ping1Jinglei Qin2Mu Yang3Xi Wu4Mei You5Fangtian You6Hongshang Peng7Key Laboratory of Luminescence and Optical Information, Ministry of Education, Institute of Optoelectronic Technology, Beijing Jiaotong University, Beijing 100044, ChinaSchool of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, ChinaKey Laboratory of Luminescence and Optical Information, Ministry of Education, Institute of Optoelectronic Technology, Beijing Jiaotong University, Beijing 100044, ChinaKey Laboratory of Luminescence and Optical Information, Ministry of Education, Institute of Optoelectronic Technology, Beijing Jiaotong University, Beijing 100044, ChinaOptoelectronics Research Center, College of Science, Minzu University of China, Beijing 100081, ChinaOptoelectronics Research Center, College of Science, Minzu University of China, Beijing 100081, ChinaKey Laboratory of Luminescence and Optical Information, Ministry of Education, Institute of Optoelectronic Technology, Beijing Jiaotong University, Beijing 100044, ChinaOptoelectronics Research Center, College of Science, Minzu University of China, Beijing 100081, ChinaAlthough hollow mesoporous silica nanoparticles (HMSNs) have been intensively studied as nanocarriers, selecting the right HMSNs for specific drugs still remains challenging due to the enormous diversity in so far reported HMSNs and drugs. To this end, we herein made a comprehensive study on drug loading in HMSNs from the viewpoint of impacting factors and loading efficiency. Specifically, two types of HMSNs with negative and positive zeta potential were delicately constructed, and three categories of drugs were selected as delivery targets: highly hydrophobic and lipophobic (oily), hydrophobic, and hydrophilic. The results indicated that (i) oily drugs could be efficiently loaded into both of the two HMSNs, (ii) HMSNs were not good carriers for hydrophobic drugs, especially for planar drugs, (iii) HMSNs had high loading efficiency towards oppositely charged hydrophilic drugs, i.e., negatively charged HMSNs for cationic molecules and vice versa, (iv) entrapped drugs would alter zeta potential of drug-loaded HMSNs. This work may provide general guidelines about designing high-payload HMSNs by reference to the physicochemical property of drugs.https://www.mdpi.com/2079-4991/11/5/1293hollow mesoporous silica nanoparticleloading efficiencypore sizecavity diameterzeta potential |
| spellingShingle | Lanying Guo Jiantao Ping Jinglei Qin Mu Yang Xi Wu Mei You Fangtian You Hongshang Peng A Comprehensive Study of Drug Loading in Hollow Mesoporous Silica Nanoparticles: Impacting Factors and Loading Efficiency Nanomaterials hollow mesoporous silica nanoparticle loading efficiency pore size cavity diameter zeta potential |
| title | A Comprehensive Study of Drug Loading in Hollow Mesoporous Silica Nanoparticles: Impacting Factors and Loading Efficiency |
| title_full | A Comprehensive Study of Drug Loading in Hollow Mesoporous Silica Nanoparticles: Impacting Factors and Loading Efficiency |
| title_fullStr | A Comprehensive Study of Drug Loading in Hollow Mesoporous Silica Nanoparticles: Impacting Factors and Loading Efficiency |
| title_full_unstemmed | A Comprehensive Study of Drug Loading in Hollow Mesoporous Silica Nanoparticles: Impacting Factors and Loading Efficiency |
| title_short | A Comprehensive Study of Drug Loading in Hollow Mesoporous Silica Nanoparticles: Impacting Factors and Loading Efficiency |
| title_sort | comprehensive study of drug loading in hollow mesoporous silica nanoparticles impacting factors and loading efficiency |
| topic | hollow mesoporous silica nanoparticle loading efficiency pore size cavity diameter zeta potential |
| url | https://www.mdpi.com/2079-4991/11/5/1293 |
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