Microgravity induces pelvic bone loss through osteoclastic activity, osteocytic osteolysis, and osteoblastic cell cycle inhibition by CDKN1a/p21.

Microgravity induces pelvic bone loss through osteoclastic activity, osteocytic osteolysis, and osteoblastic cell cycle inhibition by CDKN1a/p21.

Bone is a dynamically remodeled tissue that requires gravity-mediated mechanical stimulation for maintenance of mineral content and structure. Homeostasis in bone occurs through a balance in the activities and signaling of osteoclasts, osteoblasts, and osteocytes, as well as proliferation and differ...

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Bibliographic Details
Main Authors: Elizabeth A Blaber, Natalya Dvorochkin, Chialing Lee, Joshua S Alwood, Rukhsana Yousuf, Piero Pianetta, Ruth K Globus, Brendan P Burns, Eduardo A C Almeida
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23637819/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23637819/?tool=EBI

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