Effects of Cinnamon Powder on Glucose Metabolism in Diabetic Mice and the Molecular Mechanisms
The liver is the primary organ regulating glucose metabolism. In our recent study, cinnamon improved liver function in diabetic mice. However, it is not clear whether cinnamon can reduce the glycemia of diabetic animals by regulating liver glucose metabolism. The purpose of this study was to investi...
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MDPI AG
2023-10-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/12/20/3852 |
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| author | Yaoyao Liu Fan Liu Dongxu Xing Weifei Wang Qiong Yang Sentai Liao Erna Li Daorui Pang Yuxiao Zou |
| author_facet | Yaoyao Liu Fan Liu Dongxu Xing Weifei Wang Qiong Yang Sentai Liao Erna Li Daorui Pang Yuxiao Zou |
| author_sort | Yaoyao Liu |
| collection | DOAJ |
| description | The liver is the primary organ regulating glucose metabolism. In our recent study, cinnamon improved liver function in diabetic mice. However, it is not clear whether cinnamon can reduce the glycemia of diabetic animals by regulating liver glucose metabolism. The purpose of this study was to investigate the hypoglycemic mechanism of cinnamon powder (CP) from the perspective of regulating liver glucose metabolism. To achieve this, different doses of CP (200, 400, or 800 mg/kg body weight) were given to diabetic mice by gavage once per day for 8 weeks. These mice were compared with healthy controls, untreated diabetic mice, and diabetic mice treated with metformin (the main first-line drug for type 2 diabetes). CP treatment effectively reduced fasting blood glucose levels and food intake, improved glucose tolerance and fasting serum insulin levels, and decreased glycated serum protein levels in diabetic mice. Furthermore, treatment with CP increased liver glycogen content and reduced the level of the gluconeogenesis precursor pyruvate in the liver. Data obtained by qPCR and western blotting suggested that CP improved glucose metabolism disorders by regulating AMPKα/PGC1α-mediated hepatic gluconeogenesis and PI3K/AKT-mediated hepatic glycogen synthesis. CP exhibits good hypoglycemic effects by improving hepatic glycogen synthesis and controlling hepatic gluconeogenesis. Therefore, CP may be applied as a functional food to decrease blood glucose. |
| first_indexed | 2024-03-10T21:14:59Z |
| format | Article |
| id | doaj.art-b65cd9782be24945b26706a815feb211 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T21:14:59Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-b65cd9782be24945b26706a815feb2112023-11-19T16:30:45ZengMDPI AGFoods2304-81582023-10-011220385210.3390/foods12203852Effects of Cinnamon Powder on Glucose Metabolism in Diabetic Mice and the Molecular MechanismsYaoyao Liu0Fan Liu1Dongxu Xing2Weifei Wang3Qiong Yang4Sentai Liao5Erna Li6Daorui Pang7Yuxiao Zou8Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, ChinaSericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, ChinaSericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, ChinaSericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, ChinaSericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, ChinaSericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, ChinaSericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, ChinaSericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, ChinaSericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, ChinaThe liver is the primary organ regulating glucose metabolism. In our recent study, cinnamon improved liver function in diabetic mice. However, it is not clear whether cinnamon can reduce the glycemia of diabetic animals by regulating liver glucose metabolism. The purpose of this study was to investigate the hypoglycemic mechanism of cinnamon powder (CP) from the perspective of regulating liver glucose metabolism. To achieve this, different doses of CP (200, 400, or 800 mg/kg body weight) were given to diabetic mice by gavage once per day for 8 weeks. These mice were compared with healthy controls, untreated diabetic mice, and diabetic mice treated with metformin (the main first-line drug for type 2 diabetes). CP treatment effectively reduced fasting blood glucose levels and food intake, improved glucose tolerance and fasting serum insulin levels, and decreased glycated serum protein levels in diabetic mice. Furthermore, treatment with CP increased liver glycogen content and reduced the level of the gluconeogenesis precursor pyruvate in the liver. Data obtained by qPCR and western blotting suggested that CP improved glucose metabolism disorders by regulating AMPKα/PGC1α-mediated hepatic gluconeogenesis and PI3K/AKT-mediated hepatic glycogen synthesis. CP exhibits good hypoglycemic effects by improving hepatic glycogen synthesis and controlling hepatic gluconeogenesis. Therefore, CP may be applied as a functional food to decrease blood glucose.https://www.mdpi.com/2304-8158/12/20/3852cinnamon powderhypoglycemiaglycogen synthesisgluconeogenesis |
| spellingShingle | Yaoyao Liu Fan Liu Dongxu Xing Weifei Wang Qiong Yang Sentai Liao Erna Li Daorui Pang Yuxiao Zou Effects of Cinnamon Powder on Glucose Metabolism in Diabetic Mice and the Molecular Mechanisms Foods cinnamon powder hypoglycemia glycogen synthesis gluconeogenesis |
| title | Effects of Cinnamon Powder on Glucose Metabolism in Diabetic Mice and the Molecular Mechanisms |
| title_full | Effects of Cinnamon Powder on Glucose Metabolism in Diabetic Mice and the Molecular Mechanisms |
| title_fullStr | Effects of Cinnamon Powder on Glucose Metabolism in Diabetic Mice and the Molecular Mechanisms |
| title_full_unstemmed | Effects of Cinnamon Powder on Glucose Metabolism in Diabetic Mice and the Molecular Mechanisms |
| title_short | Effects of Cinnamon Powder on Glucose Metabolism in Diabetic Mice and the Molecular Mechanisms |
| title_sort | effects of cinnamon powder on glucose metabolism in diabetic mice and the molecular mechanisms |
| topic | cinnamon powder hypoglycemia glycogen synthesis gluconeogenesis |
| url | https://www.mdpi.com/2304-8158/12/20/3852 |
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