Risk factors and treatments for disseminated intravascular coagulation in neonates
Abstract Background Although disseminated intravascular coagulation (DIC) is a critical disease, there is few gold standard interventions in neonatal medicine. The aim of this study is to reveal factors affecting neonatal DIC at birth and to assess the effectiveness of rTM and FFP for DIC in neonate...
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| Format: | Article |
| Language: | English |
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BMC
2020-04-01
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| Series: | Italian Journal of Pediatrics |
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| Online Access: | http://link.springer.com/article/10.1186/s13052-020-0815-7 |
| _version_ | 1818253034710368256 |
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| author | Hayato Go Hitoshi Ohto Kenneth E. Nollet Nozomi Kashiwabara Kei Ogasawara Mina Chishiki Shun Hiruta Ichiri Sakuma Yukihiko Kawasaki Mitsuaki Hosoya |
| author_facet | Hayato Go Hitoshi Ohto Kenneth E. Nollet Nozomi Kashiwabara Kei Ogasawara Mina Chishiki Shun Hiruta Ichiri Sakuma Yukihiko Kawasaki Mitsuaki Hosoya |
| author_sort | Hayato Go |
| collection | DOAJ |
| description | Abstract Background Although disseminated intravascular coagulation (DIC) is a critical disease, there is few gold standard interventions in neonatal medicine. The aim of this study is to reveal factors affecting neonatal DIC at birth and to assess the effectiveness of rTM and FFP for DIC in neonates at birth. Methods We retrospectively evaluated DIC score on the first day of life in neonates with underlying conditions associated with DIC. DIC in neonates was diagnosed according to Japan Society of Obstetrical, Gynecological & Neonatal Hematology 2016 neonatal DIC criteria. Results Comparing neonates with DIC scores of ≥3 (n = 103) to those < 3 (n = 263), SGA, birth asphyxia, low Apgar score, hemangioma, hydrops, PIH, and PA were statistically increased. Among 55 neonates underwent DIC treatment, 53 had birth asphyxia and 12 had intraventricular hemorrhage. Forty-one neonates received FFP or a combination of FFP and antithrombin (FFP group), while 14 neonates received rTM or a combination of rTM, FFP, and antithrombin (rTM group). DIC score before treatment in the rTM group was significantly higher than in the FFP group (4.7 vs 3.6, P < 0.05). After treatment, DIC scores in both groups were significantly reduced on Day 1 and Day 2 (P < 0.05). Conclusions Among various factors associated with DIC in neonates at birth, birth asphyxia is particularly significant. Furthermore, rTM in combination with FFP therapy was effective for neonatal DIC at birth. |
| first_indexed | 2024-12-12T16:33:39Z |
| format | Article |
| id | doaj.art-b65e555ca1f24135b40720734e7da159 |
| institution | Directory Open Access Journal |
| issn | 1824-7288 |
| language | English |
| last_indexed | 2024-12-12T16:33:39Z |
| publishDate | 2020-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Italian Journal of Pediatrics |
| spelling | doaj.art-b65e555ca1f24135b40720734e7da1592022-12-22T00:18:43ZengBMCItalian Journal of Pediatrics1824-72882020-04-014611710.1186/s13052-020-0815-7Risk factors and treatments for disseminated intravascular coagulation in neonatesHayato Go0Hitoshi Ohto1Kenneth E. Nollet2Nozomi Kashiwabara3Kei Ogasawara4Mina Chishiki5Shun Hiruta6Ichiri Sakuma7Yukihiko Kawasaki8Mitsuaki Hosoya9Department of Pediatrics, Fukushima Medical University School of MedicineDepartment of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of MedicineDepartment of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of MedicineDepartment of Pediatrics, Fukushima Medical University School of MedicineDepartment of Pediatrics, Fukushima Medical University School of MedicineDepartment of Pediatrics, Fukushima Medical University School of MedicineDepartment of Pediatrics, Fukushima Medical University School of MedicineDepartment of Pediatrics, Fukushima Medical University School of MedicineDepartment of Pediatrics, Fukushima Medical University School of MedicineDepartment of Pediatrics, Fukushima Medical University School of MedicineAbstract Background Although disseminated intravascular coagulation (DIC) is a critical disease, there is few gold standard interventions in neonatal medicine. The aim of this study is to reveal factors affecting neonatal DIC at birth and to assess the effectiveness of rTM and FFP for DIC in neonates at birth. Methods We retrospectively evaluated DIC score on the first day of life in neonates with underlying conditions associated with DIC. DIC in neonates was diagnosed according to Japan Society of Obstetrical, Gynecological & Neonatal Hematology 2016 neonatal DIC criteria. Results Comparing neonates with DIC scores of ≥3 (n = 103) to those < 3 (n = 263), SGA, birth asphyxia, low Apgar score, hemangioma, hydrops, PIH, and PA were statistically increased. Among 55 neonates underwent DIC treatment, 53 had birth asphyxia and 12 had intraventricular hemorrhage. Forty-one neonates received FFP or a combination of FFP and antithrombin (FFP group), while 14 neonates received rTM or a combination of rTM, FFP, and antithrombin (rTM group). DIC score before treatment in the rTM group was significantly higher than in the FFP group (4.7 vs 3.6, P < 0.05). After treatment, DIC scores in both groups were significantly reduced on Day 1 and Day 2 (P < 0.05). Conclusions Among various factors associated with DIC in neonates at birth, birth asphyxia is particularly significant. Furthermore, rTM in combination with FFP therapy was effective for neonatal DIC at birth.http://link.springer.com/article/10.1186/s13052-020-0815-7DIC scoreUnderlying conditionsFresh frozen plasmaRecombinant thrombomodulinNeonatesBirth asphyxia |
| spellingShingle | Hayato Go Hitoshi Ohto Kenneth E. Nollet Nozomi Kashiwabara Kei Ogasawara Mina Chishiki Shun Hiruta Ichiri Sakuma Yukihiko Kawasaki Mitsuaki Hosoya Risk factors and treatments for disseminated intravascular coagulation in neonates Italian Journal of Pediatrics DIC score Underlying conditions Fresh frozen plasma Recombinant thrombomodulin Neonates Birth asphyxia |
| title | Risk factors and treatments for disseminated intravascular coagulation in neonates |
| title_full | Risk factors and treatments for disseminated intravascular coagulation in neonates |
| title_fullStr | Risk factors and treatments for disseminated intravascular coagulation in neonates |
| title_full_unstemmed | Risk factors and treatments for disseminated intravascular coagulation in neonates |
| title_short | Risk factors and treatments for disseminated intravascular coagulation in neonates |
| title_sort | risk factors and treatments for disseminated intravascular coagulation in neonates |
| topic | DIC score Underlying conditions Fresh frozen plasma Recombinant thrombomodulin Neonates Birth asphyxia |
| url | http://link.springer.com/article/10.1186/s13052-020-0815-7 |
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