Design and Synthesis of Some New Quinoline Based 1,2,3-Triazoles as Antimicrobial and Antimalarial Agents
A series of novel 6-bromo-2-chloro-3-(4-phenyl-[1,2,3]triazol-1-ylmethyl)-quinoline and its derivatives (5a-j) were synthesized in good yields from the intermediates (6-bromo-2-chloro-quinolin-3-yl)-methanol (2), methanesulfonic acid (6-bromo-2-chloroquinolin-3-yl)methyl methanesulfonate (3) and 3-a...
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| Format: | Article |
| Language: | English |
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Universidade Federal de Mato Grosso do Sul
2015-09-01
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| Series: | Orbital: The Electronic Journal of Chemistry |
| Subjects: | |
| Online Access: | https://periodicos.ufms.br/index.php/orbital/article/view/17869 |
| _version_ | 1828057788588228608 |
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| author | Parthasaradhi Y. Suresh S. Ranjith Kumar B. Savitha Jyostna T. |
| author_facet | Parthasaradhi Y. Suresh S. Ranjith Kumar B. Savitha Jyostna T. |
| author_sort | Parthasaradhi Y. |
| collection | DOAJ |
| description | A series of novel 6-bromo-2-chloro-3-(4-phenyl-[1,2,3]triazol-1-ylmethyl)-quinoline and its derivatives (5a-j) were synthesized in good yields from the intermediates (6-bromo-2-chloro-quinolin-3-yl)-methanol (2), methanesulfonic acid (6-bromo-2-chloroquinolin-3-yl)methyl methanesulfonate (3) and 3-azidomethyl-6-bromo-2-chloro-quinoline (4). The synthetic route leading to the title compounds is commenced from commercially available 6-bromo-2-chloro-quinolin-3-carbaldehyde (1). The chemical structures of the newly synthesized compounds were elucidated by their IR, 1H and 13C NMR, mass spectral data and elemental analysis. Further, all the target compounds were screened for their antimicrobial activity against various microorganisms and antimalarial activity towards P. falciparum.
DOI: http://dx.doi.org/10.17807/orbital.v7i3.692
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| first_indexed | 2024-04-10T21:17:47Z |
| format | Article |
| id | doaj.art-b66337cece2f40dd85a62226668d2a51 |
| institution | Directory Open Access Journal |
| issn | 1984-6428 |
| language | English |
| last_indexed | 2024-04-10T21:17:47Z |
| publishDate | 2015-09-01 |
| publisher | Universidade Federal de Mato Grosso do Sul |
| record_format | Article |
| series | Orbital: The Electronic Journal of Chemistry |
| spelling | doaj.art-b66337cece2f40dd85a62226668d2a512023-01-20T11:03:46ZengUniversidade Federal de Mato Grosso do SulOrbital: The Electronic Journal of Chemistry1984-64282015-09-0173Design and Synthesis of Some New Quinoline Based 1,2,3-Triazoles as Antimicrobial and Antimalarial AgentsParthasaradhi Y.0Suresh S.1Ranjith Kumar B.2Savitha Jyostna T.3Department of Chemistry, Kakatiya UniversityDepartment of Chemistry, Kakatiya UniversityDepartment of Chemistry, Kakatiya UniversityDepartment of Chemistry, Kakatiya UniversityA series of novel 6-bromo-2-chloro-3-(4-phenyl-[1,2,3]triazol-1-ylmethyl)-quinoline and its derivatives (5a-j) were synthesized in good yields from the intermediates (6-bromo-2-chloro-quinolin-3-yl)-methanol (2), methanesulfonic acid (6-bromo-2-chloroquinolin-3-yl)methyl methanesulfonate (3) and 3-azidomethyl-6-bromo-2-chloro-quinoline (4). The synthetic route leading to the title compounds is commenced from commercially available 6-bromo-2-chloro-quinolin-3-carbaldehyde (1). The chemical structures of the newly synthesized compounds were elucidated by their IR, 1H and 13C NMR, mass spectral data and elemental analysis. Further, all the target compounds were screened for their antimicrobial activity against various microorganisms and antimalarial activity towards P. falciparum. DOI: http://dx.doi.org/10.17807/orbital.v7i3.692 https://periodicos.ufms.br/index.php/orbital/article/view/17869quinolonetriazolesantimicrobial activityantimalarial |
| spellingShingle | Parthasaradhi Y. Suresh S. Ranjith Kumar B. Savitha Jyostna T. Design and Synthesis of Some New Quinoline Based 1,2,3-Triazoles as Antimicrobial and Antimalarial Agents Orbital: The Electronic Journal of Chemistry quinolone triazoles antimicrobial activity antimalarial |
| title | Design and Synthesis of Some New Quinoline Based 1,2,3-Triazoles as Antimicrobial and Antimalarial Agents |
| title_full | Design and Synthesis of Some New Quinoline Based 1,2,3-Triazoles as Antimicrobial and Antimalarial Agents |
| title_fullStr | Design and Synthesis of Some New Quinoline Based 1,2,3-Triazoles as Antimicrobial and Antimalarial Agents |
| title_full_unstemmed | Design and Synthesis of Some New Quinoline Based 1,2,3-Triazoles as Antimicrobial and Antimalarial Agents |
| title_short | Design and Synthesis of Some New Quinoline Based 1,2,3-Triazoles as Antimicrobial and Antimalarial Agents |
| title_sort | design and synthesis of some new quinoline based 1 2 3 triazoles as antimicrobial and antimalarial agents |
| topic | quinolone triazoles antimicrobial activity antimalarial |
| url | https://periodicos.ufms.br/index.php/orbital/article/view/17869 |
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