RNA-binding protein Ptbp1 regulates alternative splicing and transcriptome in spermatogonia and maintains spermatogenesis in concert with Nanos3

RNA-binding protein Ptbp1 regulates alternative splicing and transcriptome in spermatogonia and maintains spermatogenesis in concert with Nanos3

PTBP1, a well-conserved RNA-binding protein, regulates cellular development by tuning posttranscriptional mRNA modification such as alternative splicing (AS) or mRNA stabilization. We previously revealed that the loss of Ptbp1 in spermatogonia causes the dysregulation of spermatogenesis, but the mol...

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Bibliographic Details
Main Authors: Manami SENOO, Hiroshi HOZOJI, Yu ISHIKAWA-YAMAUCHI, Takashi TAKIJIRI, Sho OHTA, Tomoyo UKAI, Mio KABATA, Takuya YAMAMOTO, Yasuhiro YAMADA, Masahito IKAWA, Manabu OZAWA
Format: Article
Language:English
Published: The Society for Reproduction and Development 2020-07-01
Series:The Journal of Reproduction and Development
Subjects:
alternative splicing
ptbp1
rna-binding protein
spermatogonia
spermatogenesis
Online Access:https://www.jstage.jst.go.jp/article/jrd/66/5/66_2020-060/_pdf/-char/en

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