Murder on the Ovarian Express: A Tale of Non-Autonomous Cell Death in the <i>Drosophila</i> Ovary
Throughout oogenesis, <i>Drosophila</i> egg chambers traverse the fine line between survival and death. After surviving the ten early and middle stages of oogenesis, egg chambers drastically change their size and structure to produce fully developed oocytes. The development of an oocyte...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/6/1454 |
| _version_ | 1797530685260431360 |
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| author | Diane Patricia Vig Lebo Kimberly McCall |
| author_facet | Diane Patricia Vig Lebo Kimberly McCall |
| author_sort | Diane Patricia Vig Lebo |
| collection | DOAJ |
| description | Throughout oogenesis, <i>Drosophila</i> egg chambers traverse the fine line between survival and death. After surviving the ten early and middle stages of oogenesis, egg chambers drastically change their size and structure to produce fully developed oocytes. The development of an oocyte comes at a cost, the price is the lives of the oocyte’s 15 siblings, the nurse cells. These nurse cells do not die of their own accord. Their death is dependent upon their neighbors—the stretch follicle cells. Stretch follicle cells are nonprofessional phagocytes that spend the final stages of oogenesis surrounding the nurse cells and subsequently forcing the nurse cells to give up everything for the sake of the oocyte. In this review, we provide an overview of cell death in the ovary, with a focus on recent findings concerning this phagocyte-dependent non-autonomous cell death. |
| first_indexed | 2024-03-10T10:32:33Z |
| format | Article |
| id | doaj.art-b6637da8dc0c4b02ab23bdc98ccc3975 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T10:32:33Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-b6637da8dc0c4b02ab23bdc98ccc39752023-11-21T23:31:22ZengMDPI AGCells2073-44092021-06-01106145410.3390/cells10061454Murder on the Ovarian Express: A Tale of Non-Autonomous Cell Death in the <i>Drosophila</i> OvaryDiane Patricia Vig Lebo0Kimberly McCall1Department of Biology, 5 Cummington Mall, Boston University, Boston, MA 02215, USADepartment of Biology, 5 Cummington Mall, Boston University, Boston, MA 02215, USAThroughout oogenesis, <i>Drosophila</i> egg chambers traverse the fine line between survival and death. After surviving the ten early and middle stages of oogenesis, egg chambers drastically change their size and structure to produce fully developed oocytes. The development of an oocyte comes at a cost, the price is the lives of the oocyte’s 15 siblings, the nurse cells. These nurse cells do not die of their own accord. Their death is dependent upon their neighbors—the stretch follicle cells. Stretch follicle cells are nonprofessional phagocytes that spend the final stages of oogenesis surrounding the nurse cells and subsequently forcing the nurse cells to give up everything for the sake of the oocyte. In this review, we provide an overview of cell death in the ovary, with a focus on recent findings concerning this phagocyte-dependent non-autonomous cell death.https://www.mdpi.com/2073-4409/10/6/1454<i>Drosophila</i>ovaryoogenesiscell corpse clearancephagocytosisefferocytosis |
| spellingShingle | Diane Patricia Vig Lebo Kimberly McCall Murder on the Ovarian Express: A Tale of Non-Autonomous Cell Death in the <i>Drosophila</i> Ovary Cells <i>Drosophila</i> ovary oogenesis cell corpse clearance phagocytosis efferocytosis |
| title | Murder on the Ovarian Express: A Tale of Non-Autonomous Cell Death in the <i>Drosophila</i> Ovary |
| title_full | Murder on the Ovarian Express: A Tale of Non-Autonomous Cell Death in the <i>Drosophila</i> Ovary |
| title_fullStr | Murder on the Ovarian Express: A Tale of Non-Autonomous Cell Death in the <i>Drosophila</i> Ovary |
| title_full_unstemmed | Murder on the Ovarian Express: A Tale of Non-Autonomous Cell Death in the <i>Drosophila</i> Ovary |
| title_short | Murder on the Ovarian Express: A Tale of Non-Autonomous Cell Death in the <i>Drosophila</i> Ovary |
| title_sort | murder on the ovarian express a tale of non autonomous cell death in the i drosophila i ovary |
| topic | <i>Drosophila</i> ovary oogenesis cell corpse clearance phagocytosis efferocytosis |
| url | https://www.mdpi.com/2073-4409/10/6/1454 |
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