Lion’s Mane (<i>Hericium erinaceus</i>) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model
Alzheimer’s disease (AD) significantly impairs the life of an individual both cognitively and behaviorally. Tau and beta-amyloid (Aβ) proteins are major contributors to the etiology of AD. This study used mice modeling AD through the presence of tau pathology to assess the effects of <i>Herici...
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MDPI AG
2022-07-01
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author | Mya N. Rodriguez Stephen L. P. Lippi |
author_facet | Mya N. Rodriguez Stephen L. P. Lippi |
author_sort | Mya N. Rodriguez |
collection | DOAJ |
description | Alzheimer’s disease (AD) significantly impairs the life of an individual both cognitively and behaviorally. Tau and beta-amyloid (Aβ) proteins are major contributors to the etiology of AD. This study used mice modeling AD through the presence of tau pathology to assess the effects of <i>Hericium erinaceus</i> (<i>H. erinaceus</i>), also known as Lion’s mane, on cognitive and non-cognitive behaviors. Despite neurocognitive and neurobiological effects of <i>H. erinaceus</i> being seen in both healthy and transgenic mice, no research to date has explored its effects on mice with solely tau pathology. In this study, mice were placed on a diet supplemented with <i>H. erinaceus</i> or a standard rodent diet for 4.5 months in order to determine the effect of this medicinal mushroom on behavior. Tau mice given <i>H. erinaceus</i> had significantly shorter latencies to enter the center of the open field (OF) (<i>p</i> < 0.05) and spent significantly more time in the open arms of the elevated zero maze (EZM) (<i>p</i> < 0.001) compared to tau control mice. Mice given <i>H. erinaceus</i> spent significantly more time in the open arms of and made more head dips in the elevated zero maze (EZM) (<i>p</i> < 0.05). While <i>H. erinaceus</i> had anxiolytic effects, no improvements were seen in spatial memory or activities of daily living. These findings provide additional support for the anxiolytic effects of <i>H. erinaceus</i> and point to its potential benefit as a therapeutic for anxiety in AD. |
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publishDate | 2022-07-01 |
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spelling | doaj.art-b66406c74e3449c589a55041559893c22023-12-03T14:40:14ZengMDPI AGBehavioral Sciences2076-328X2022-07-0112723510.3390/bs12070235Lion’s Mane (<i>Hericium erinaceus</i>) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse ModelMya N. Rodriguez0Stephen L. P. Lippi1Department Psychology, Angelo State University, San Angelo, TX 76909, USADepartment Psychology, Angelo State University, San Angelo, TX 76909, USAAlzheimer’s disease (AD) significantly impairs the life of an individual both cognitively and behaviorally. Tau and beta-amyloid (Aβ) proteins are major contributors to the etiology of AD. This study used mice modeling AD through the presence of tau pathology to assess the effects of <i>Hericium erinaceus</i> (<i>H. erinaceus</i>), also known as Lion’s mane, on cognitive and non-cognitive behaviors. Despite neurocognitive and neurobiological effects of <i>H. erinaceus</i> being seen in both healthy and transgenic mice, no research to date has explored its effects on mice with solely tau pathology. In this study, mice were placed on a diet supplemented with <i>H. erinaceus</i> or a standard rodent diet for 4.5 months in order to determine the effect of this medicinal mushroom on behavior. Tau mice given <i>H. erinaceus</i> had significantly shorter latencies to enter the center of the open field (OF) (<i>p</i> < 0.05) and spent significantly more time in the open arms of the elevated zero maze (EZM) (<i>p</i> < 0.001) compared to tau control mice. Mice given <i>H. erinaceus</i> spent significantly more time in the open arms of and made more head dips in the elevated zero maze (EZM) (<i>p</i> < 0.05). While <i>H. erinaceus</i> had anxiolytic effects, no improvements were seen in spatial memory or activities of daily living. These findings provide additional support for the anxiolytic effects of <i>H. erinaceus</i> and point to its potential benefit as a therapeutic for anxiety in AD.https://www.mdpi.com/2076-328X/12/7/235Alzheimer’s diseaseanxietytaumicebehaviormushrooms |
spellingShingle | Mya N. Rodriguez Stephen L. P. Lippi Lion’s Mane (<i>Hericium erinaceus</i>) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model Behavioral Sciences Alzheimer’s disease anxiety tau mice behavior mushrooms |
title | Lion’s Mane (<i>Hericium erinaceus</i>) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model |
title_full | Lion’s Mane (<i>Hericium erinaceus</i>) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model |
title_fullStr | Lion’s Mane (<i>Hericium erinaceus</i>) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model |
title_full_unstemmed | Lion’s Mane (<i>Hericium erinaceus</i>) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model |
title_short | Lion’s Mane (<i>Hericium erinaceus</i>) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model |
title_sort | lion s mane i hericium erinaceus i exerts anxiolytic effects in the rtg4510 tau mouse model |
topic | Alzheimer’s disease anxiety tau mice behavior mushrooms |
url | https://www.mdpi.com/2076-328X/12/7/235 |
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