TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells

TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells

Abstract Background Pancreatic ductal adenocarcinoma is one of the most aggressive cancers, with a 5-year survival rate of less than 8%. The complicated tumor microenvironment, particularly TGF-β, provides possible convenience for the progression of PC cells. TGF-β regulates critical cellular proces...

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Bibliographic Details
Main Authors: Ruizhi He, Min Wang, Chunle Zhao, Ming Shen, Yahong Yu, Li He, Yan Zhao, Hua Chen, Xiuhui Shi, Min Zhou, Shutao Pan, Yuhui Liu, Xingjun Guo, Xu Li, Renyi Qin
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Autophagy
TFEB
Endocytosis
Focal adhesion
Pancreatic cancer
Online Access:http://link.springer.com/article/10.1186/s13046-019-1343-4

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