GABAA receptor dephosphorylation followed by internalization is coupled to neuronal death in in vitro ischemia

GABAA receptor dephosphorylation followed by internalization is coupled to neuronal death in in vitro ischemia

Cerebral ischemia is characterized by an early disruption of GABAergic neurotransmission contributing to an imbalance of the excitatory/inhibitory equilibrium and neuronal death, but the molecular mechanisms involved are not fully understood. Here we report a downregulation of GABAA receptor (GABAAR...

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Bibliographic Details
Main Authors: Miranda Mele, Luís Ribeiro, Ana R. Inácio, Tadeusz Wieloch, Carlos B. Duarte
Format: Article
Language:English
Published: Elsevier 2014-05-01
Series:Neurobiology of Disease
Subjects:
Neuroprotection
GABAA receptors
Brain ischemia
Receptor traffic
Gephyrin
Calpains
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114000333

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