Microglia-Dependent and Independent Brain Cytoprotective Effects of Mycophenolate Mofetil During Neuronal Damage

Microglia-Dependent and Independent Brain Cytoprotective Effects of Mycophenolate Mofetil During Neuronal Damage

Acute lesions of the central nervous system often lead to permanent limiting deficits. In addition to the initial primary damage, accompanying neuroinflammation is responsible for progression of damage. Mycophenolate mofetil (MMF) as a selective inhibitor of inosine 5-monophosphate dehydrogenase (IM...

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Bibliographic Details
Main Authors: Joshua Kleine, Urszula Hohmann, Tim Hohmann, Chalid Ghadban, Miriam Schmidt, Sebastian Laabs, Beat Alessandri, Faramarz Dehghani
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
microglia
astrocytes
OHSC
neuroinflammation
IMPDH2
mycophenolate mofetil (MMF)
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.863598/full

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