IL1RL1 single nucleotide polymorphisms are associated with asthma in the Iranian population
Asthma is a chronic and multifactorial disease which is known to result from environmental and genetic factors. Interleukin 1 receptor-like 1 (IL1RL1) is a receptor, which promotes inflammatory responses after binding to its ligand IL-33. Several studies have shown that IL1RL1 gene polymorphisms are...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2021-12-01
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| Series: | Monaldi Archives for Chest Disease |
| Subjects: | |
| Online Access: | https://www.monaldi-archives.org/index.php/macd/article/view/1697 |
| _version_ | 1818986392272764928 |
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| author | Maral Ranjbar Mojdeh Matloubi Shaghayegh Sadegh Morteza Fallahpour Leila Janani Mohammad-Ali Assarehzadegan |
| author_facet | Maral Ranjbar Mojdeh Matloubi Shaghayegh Sadegh Morteza Fallahpour Leila Janani Mohammad-Ali Assarehzadegan |
| author_sort | Maral Ranjbar |
| collection | DOAJ |
| description | Asthma is a chronic and multifactorial disease which is known to result from environmental and genetic factors. Interleukin 1 receptor-like 1 (IL1RL1) is a receptor, which promotes inflammatory responses after binding to its ligand IL-33. Several studies have shown that IL1RL1 gene polymorphisms are related to susceptibility or protection to asthma. The objective of this study was to evaluate the association between two IL1RL1 single nucleotide polymorphisms (rs10208293 and rs1041973) and the risk of asthma in the Iranian population. We performed genotyping of the IL1RL1 SNPs in 126 adult asthmatics and 300 healthy controls using TaqMan genotyping assay. Moreover, total serum IgE level, eosinophil count, and skin prick test were accomplished. The results indicated that the AA genotype of rs10208293 was positively associated with asthma susceptibility (p=0.028). We did not find any association between rs1041973 and asthma. Overall, our findings indicate that rs10208293 has a positive association with asthma in the Iranian population. |
| first_indexed | 2024-12-20T18:50:04Z |
| format | Article |
| id | doaj.art-b667545bb76a4060836d2da5bb43217a |
| institution | Directory Open Access Journal |
| issn | 1122-0643 2532-5264 |
| language | English |
| last_indexed | 2024-12-20T18:50:04Z |
| publishDate | 2021-12-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Monaldi Archives for Chest Disease |
| spelling | doaj.art-b667545bb76a4060836d2da5bb43217a2022-12-21T19:29:37ZengPAGEPress PublicationsMonaldi Archives for Chest Disease1122-06432532-52642021-12-0110.4081/monaldi.2021.1697IL1RL1 single nucleotide polymorphisms are associated with asthma in the Iranian populationMaral Ranjbar0Mojdeh Matloubi1Shaghayegh Sadegh2Morteza Fallahpour3Leila Janani4Mohammad-Ali Assarehzadegan5Department of Immunology, School of Medicine, Iran University of Medical Science, TehranDepartment of Immunology, School of Medicine, Iran University of Medical Science, TehranDepartment of Immunology, School of Medicine, Iran University of Medical Science, TehranDepartment of Allergy, Rasool-e-Akram Hospital, Iran University of Medical Sciences, TehranDepartment of Biostatistics, School of Public Health, Iran University of Medical Science, TehranDepartment of Immunology, School of Medicine, Iran University of Medical Science, TehranAsthma is a chronic and multifactorial disease which is known to result from environmental and genetic factors. Interleukin 1 receptor-like 1 (IL1RL1) is a receptor, which promotes inflammatory responses after binding to its ligand IL-33. Several studies have shown that IL1RL1 gene polymorphisms are related to susceptibility or protection to asthma. The objective of this study was to evaluate the association between two IL1RL1 single nucleotide polymorphisms (rs10208293 and rs1041973) and the risk of asthma in the Iranian population. We performed genotyping of the IL1RL1 SNPs in 126 adult asthmatics and 300 healthy controls using TaqMan genotyping assay. Moreover, total serum IgE level, eosinophil count, and skin prick test were accomplished. The results indicated that the AA genotype of rs10208293 was positively associated with asthma susceptibility (p=0.028). We did not find any association between rs1041973 and asthma. Overall, our findings indicate that rs10208293 has a positive association with asthma in the Iranian population.https://www.monaldi-archives.org/index.php/macd/article/view/1697Asthmaatopicsingle nucleotide polymorphisminterleukin 1 receptor-like 1 |
| spellingShingle | Maral Ranjbar Mojdeh Matloubi Shaghayegh Sadegh Morteza Fallahpour Leila Janani Mohammad-Ali Assarehzadegan IL1RL1 single nucleotide polymorphisms are associated with asthma in the Iranian population Monaldi Archives for Chest Disease Asthma atopic single nucleotide polymorphism interleukin 1 receptor-like 1 |
| title | IL1RL1 single nucleotide polymorphisms are associated with asthma in the Iranian population |
| title_full | IL1RL1 single nucleotide polymorphisms are associated with asthma in the Iranian population |
| title_fullStr | IL1RL1 single nucleotide polymorphisms are associated with asthma in the Iranian population |
| title_full_unstemmed | IL1RL1 single nucleotide polymorphisms are associated with asthma in the Iranian population |
| title_short | IL1RL1 single nucleotide polymorphisms are associated with asthma in the Iranian population |
| title_sort | il1rl1 single nucleotide polymorphisms are associated with asthma in the iranian population |
| topic | Asthma atopic single nucleotide polymorphism interleukin 1 receptor-like 1 |
| url | https://www.monaldi-archives.org/index.php/macd/article/view/1697 |
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