Clonal hematopoiesis as a novel risk factor for type 2 diabetes mellitus in patients with hypercholesterolemia
IntroductionClonal hematopoiesis of indeterminate potential (CHIP) is associated with atherosclerosis and cardiovascular disease. It has been suggested that CHIP may be related to diabetes, so we investigated the association between CHIP and new-onset type 2 diabetes.MethodsThis study included 4,047...
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Frontiers Media S.A.
2023-06-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1181879/full |
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| author | Min Joo Kim Min Joo Kim Han Song Youngil Koh Youngil Koh Heesun Lee Heesun Lee Hyo Eun Park Hyo Eun Park Sung Hee Choi Sung Hee Choi Ji Won Yoon Ji Won Yoon Su-Yeon Choi Su-Yeon Choi |
| author_facet | Min Joo Kim Min Joo Kim Han Song Youngil Koh Youngil Koh Heesun Lee Heesun Lee Hyo Eun Park Hyo Eun Park Sung Hee Choi Sung Hee Choi Ji Won Yoon Ji Won Yoon Su-Yeon Choi Su-Yeon Choi |
| author_sort | Min Joo Kim |
| collection | DOAJ |
| description | IntroductionClonal hematopoiesis of indeterminate potential (CHIP) is associated with atherosclerosis and cardiovascular disease. It has been suggested that CHIP may be related to diabetes, so we investigated the association between CHIP and new-onset type 2 diabetes.MethodsThis study included 4,047 subjects aged >=40 years without diabetes. To detect CHIP, targeted gene sequencing of genomic DNA from peripheral blood cells was performed. The incidence of new-onset type 2 diabetes during the follow-up period was evaluated.ResultsOf the total subjects, 635 (15.7%) had CHIP. During the median follow-up of 5.1 years, the incidence of new-onset diabetes was significantly higher in CHIP carriers than in subjects without CHIP (11.8% vs. 9.1%, p = 0.039). In a univariate analysis, CHIP significantly increased the risk of new-onset diabetes (HR 1.32, 95% CI 1.02–1.70, p = 0.034), but in a multivariate analysis, it was not significant. The CHIP-related risk of new onset diabetes differed according to LDL cholesterol level. In the hyper-LDL cholesterolemia group, CHIP significantly increased the risk of diabetes (HR 1.64, 95% CI 1.09–2.47, p = 0.018), but it did not increase the risk in the non-hyper-LDL cholesterolemia group. The subjects with CHIP and hyper-LDL-cholesterolemia had approximately twice the risk of diabetes than subjects without CHIP and with low LDL cholesterol (HR 2.05, 95% CI 1.40–3.00, p < 0.001).ConclusionThe presence of CHIP was a significant risk factor for new-onset type 2 diabetes, especially in subjects with high LDL cholesterol. These results show the synergism between CHIP and high LDL cholesterol as a high-risk factor for diabetes. |
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| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-03-13T02:21:18Z |
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| spelling | doaj.art-b668b5f5d69c4c80a70521aafcb6d8482023-06-30T09:52:53ZengFrontiers Media S.A.Frontiers in Public Health2296-25652023-06-011110.3389/fpubh.2023.11818791181879Clonal hematopoiesis as a novel risk factor for type 2 diabetes mellitus in patients with hypercholesterolemiaMin Joo Kim0Min Joo Kim1Han Song2Youngil Koh3Youngil Koh4Heesun Lee5Heesun Lee6Hyo Eun Park7Hyo Eun Park8Sung Hee Choi9Sung Hee Choi10Ji Won Yoon11Ji Won Yoon12Su-Yeon Choi13Su-Yeon Choi14Department of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Republic of KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of KoreaGenome Opinion Incorporation, Seoul, Republic of KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of KoreaGenome Opinion Incorporation, Seoul, Republic of KoreaDepartment of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Republic of KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Republic of KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of KoreaDepartment of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Republic of KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Republic of KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of KoreaIntroductionClonal hematopoiesis of indeterminate potential (CHIP) is associated with atherosclerosis and cardiovascular disease. It has been suggested that CHIP may be related to diabetes, so we investigated the association between CHIP and new-onset type 2 diabetes.MethodsThis study included 4,047 subjects aged >=40 years without diabetes. To detect CHIP, targeted gene sequencing of genomic DNA from peripheral blood cells was performed. The incidence of new-onset type 2 diabetes during the follow-up period was evaluated.ResultsOf the total subjects, 635 (15.7%) had CHIP. During the median follow-up of 5.1 years, the incidence of new-onset diabetes was significantly higher in CHIP carriers than in subjects without CHIP (11.8% vs. 9.1%, p = 0.039). In a univariate analysis, CHIP significantly increased the risk of new-onset diabetes (HR 1.32, 95% CI 1.02–1.70, p = 0.034), but in a multivariate analysis, it was not significant. The CHIP-related risk of new onset diabetes differed according to LDL cholesterol level. In the hyper-LDL cholesterolemia group, CHIP significantly increased the risk of diabetes (HR 1.64, 95% CI 1.09–2.47, p = 0.018), but it did not increase the risk in the non-hyper-LDL cholesterolemia group. The subjects with CHIP and hyper-LDL-cholesterolemia had approximately twice the risk of diabetes than subjects without CHIP and with low LDL cholesterol (HR 2.05, 95% CI 1.40–3.00, p < 0.001).ConclusionThe presence of CHIP was a significant risk factor for new-onset type 2 diabetes, especially in subjects with high LDL cholesterol. These results show the synergism between CHIP and high LDL cholesterol as a high-risk factor for diabetes.https://www.frontiersin.org/articles/10.3389/fpubh.2023.1181879/fullclonal hematopoiesisdiabetes mellitushematopoiesishypercholesterolemiaLDL cholesterol |
| spellingShingle | Min Joo Kim Min Joo Kim Han Song Youngil Koh Youngil Koh Heesun Lee Heesun Lee Hyo Eun Park Hyo Eun Park Sung Hee Choi Sung Hee Choi Ji Won Yoon Ji Won Yoon Su-Yeon Choi Su-Yeon Choi Clonal hematopoiesis as a novel risk factor for type 2 diabetes mellitus in patients with hypercholesterolemia Frontiers in Public Health clonal hematopoiesis diabetes mellitus hematopoiesis hypercholesterolemia LDL cholesterol |
| title | Clonal hematopoiesis as a novel risk factor for type 2 diabetes mellitus in patients with hypercholesterolemia |
| title_full | Clonal hematopoiesis as a novel risk factor for type 2 diabetes mellitus in patients with hypercholesterolemia |
| title_fullStr | Clonal hematopoiesis as a novel risk factor for type 2 diabetes mellitus in patients with hypercholesterolemia |
| title_full_unstemmed | Clonal hematopoiesis as a novel risk factor for type 2 diabetes mellitus in patients with hypercholesterolemia |
| title_short | Clonal hematopoiesis as a novel risk factor for type 2 diabetes mellitus in patients with hypercholesterolemia |
| title_sort | clonal hematopoiesis as a novel risk factor for type 2 diabetes mellitus in patients with hypercholesterolemia |
| topic | clonal hematopoiesis diabetes mellitus hematopoiesis hypercholesterolemia LDL cholesterol |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1181879/full |
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