Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma
The C-X-C chemokine receptor type 4 (CXCR4) is a pleiotropic chemokine receptor that is expressed in not only normal hematopoietic cells but also multiple myeloma cells. Its ligand, stromal cell-derived factor 1α (SDF-1α) is produced in the bone marrow microenvironment. The SDF-1α/CXCR4 axis plays a...
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| Format: | Article |
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MDPI AG
2021-04-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/8/1793 |
| _version_ | 1797538278745833472 |
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| author | Shigeki Ito Tsuyoshi Sato Takahiro Maeta |
| author_facet | Shigeki Ito Tsuyoshi Sato Takahiro Maeta |
| author_sort | Shigeki Ito |
| collection | DOAJ |
| description | The C-X-C chemokine receptor type 4 (CXCR4) is a pleiotropic chemokine receptor that is expressed in not only normal hematopoietic cells but also multiple myeloma cells. Its ligand, stromal cell-derived factor 1α (SDF-1α) is produced in the bone marrow microenvironment. The SDF-1α/CXCR4 axis plays a pivotal role in the major physiological processes associated with tumor proliferation, survival, invasion, dissemination, and drug resistance in myeloma cells. This review summarizes the pleiotropic role of the SDF-1α/CXCR4 axis in multiple myeloma and discusses the future perspective in the SDF-1α/CXCR4 axis-targeted therapies in multiple myeloma. |
| first_indexed | 2024-03-10T12:29:16Z |
| format | Article |
| id | doaj.art-b66bef31a2374691af88bfcbec263931 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T12:29:16Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b66bef31a2374691af88bfcbec2639312023-11-21T14:49:30ZengMDPI AGCancers2072-66942021-04-01138179310.3390/cancers13081793Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple MyelomaShigeki Ito0Tsuyoshi Sato1Takahiro Maeta2Division of Hematology & Oncology, Department of Internal Medicine, Iwate Medical University School of Medicine, Yahaba 028-3695, JapanDivision of Hematology & Oncology, Department of Internal Medicine, Iwate Medical University School of Medicine, Yahaba 028-3695, JapanDivision of Hematology & Oncology, Department of Internal Medicine, Iwate Medical University School of Medicine, Yahaba 028-3695, JapanThe C-X-C chemokine receptor type 4 (CXCR4) is a pleiotropic chemokine receptor that is expressed in not only normal hematopoietic cells but also multiple myeloma cells. Its ligand, stromal cell-derived factor 1α (SDF-1α) is produced in the bone marrow microenvironment. The SDF-1α/CXCR4 axis plays a pivotal role in the major physiological processes associated with tumor proliferation, survival, invasion, dissemination, and drug resistance in myeloma cells. This review summarizes the pleiotropic role of the SDF-1α/CXCR4 axis in multiple myeloma and discusses the future perspective in the SDF-1α/CXCR4 axis-targeted therapies in multiple myeloma.https://www.mdpi.com/2072-6694/13/8/1793CXCR4SDF-1αmultiple myelomadrug resistanceextramedullary disease |
| spellingShingle | Shigeki Ito Tsuyoshi Sato Takahiro Maeta Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma Cancers CXCR4 SDF-1α multiple myeloma drug resistance extramedullary disease |
| title | Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma |
| title_full | Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma |
| title_fullStr | Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma |
| title_full_unstemmed | Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma |
| title_short | Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma |
| title_sort | role and therapeutic targeting of sdf 1α cxcr4 axis in multiple myeloma |
| topic | CXCR4 SDF-1α multiple myeloma drug resistance extramedullary disease |
| url | https://www.mdpi.com/2072-6694/13/8/1793 |
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