Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma

Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma

The C-X-C chemokine receptor type 4 (CXCR4) is a pleiotropic chemokine receptor that is expressed in not only normal hematopoietic cells but also multiple myeloma cells. Its ligand, stromal cell-derived factor 1α (SDF-1α) is produced in the bone marrow microenvironment. The SDF-1α/CXCR4 axis plays a...

Full description

Bibliographic Details
Main Authors: Shigeki Ito, Tsuyoshi Sato, Takahiro Maeta
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
CXCR4
SDF-1α
multiple myeloma
drug resistance
extramedullary disease
Online Access:https://www.mdpi.com/2072-6694/13/8/1793

Similar Items

Similar Items