Dual activity of PNGM-1 pinpoints the evolutionary origin of subclass B3 metallo-β-lactamases: a molecular and evolutionary study

Dual activity of PNGM-1 pinpoints the evolutionary origin of subclass B3 metallo-β-lactamases: a molecular and evolutionary study

ABSTRACTResistance to β-lactams is one of the most serious problems associated with Gram-negative infections. β-Lactamases are able to hydrolyze β-lactams such as cephalosporins and/or carbapenems. Evolutionary origin of metallo-β-lactamases (MBLs), conferring critical antibiotic resistance threats,...

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Bibliographic Details
Main Authors: Jung Hun Lee, Masayuki Takahashi, Jeong Ho Jeon, Lin-Woo Kang, Mineaki Seki, Kwang Seung Park, Myoung-Ki Hong, Yoon Sik Park, Tae Yeong Kim, Asad Mustafa Karim, Jung-Hyun Lee, Masayuki Nashimoto, Sang Hee Lee
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Emerging Microbes and Infections
Subjects:
Antimicrobial resistance
subclass B3 metallo-β-lactamase
tRNase Z
dual activity
structure and evolutionary origin
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2019.1692638

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