The Role of Complement Dysregulation in Glaucoma
Glaucoma is a progressive neurodegenerative disease characterized by damage to the optic nerve that results in irreversible vision loss. While the exact pathology of glaucoma is not well understood, emerging evidence suggests that dysregulation of the complement system, a key component of innate imm...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/25/4/2307 |
| _version_ | 1797298029994180608 |
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| author | Cindy Hoppe Meredith Gregory-Ksander |
| author_facet | Cindy Hoppe Meredith Gregory-Ksander |
| author_sort | Cindy Hoppe |
| collection | DOAJ |
| description | Glaucoma is a progressive neurodegenerative disease characterized by damage to the optic nerve that results in irreversible vision loss. While the exact pathology of glaucoma is not well understood, emerging evidence suggests that dysregulation of the complement system, a key component of innate immunity, plays a crucial role. In glaucoma, dysregulation of the complement cascade and impaired regulation of complement factors contribute to chronic inflammation and neurodegeneration. Complement components such as C1Q, C3, and the membrane attack complex have been implicated in glaucomatous neuroinflammation and retinal ganglion cell death. This review will provide a summary of human and experimental studies that document the dysregulation of the complement system observed in glaucoma patients and animal models of glaucoma driving chronic inflammation and neurodegeneration. Understanding how complement-mediated damage contributes to glaucoma will provide opportunities for new therapies. |
| first_indexed | 2024-03-07T22:28:54Z |
| format | Article |
| id | doaj.art-b670f64bed78437f957017942253d7bc |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-07T22:28:54Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b670f64bed78437f957017942253d7bc2024-02-23T15:20:32ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-02-01254230710.3390/ijms25042307The Role of Complement Dysregulation in GlaucomaCindy Hoppe0Meredith Gregory-Ksander1Schepens Eye Research Institute of Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USASchepens Eye Research Institute of Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USAGlaucoma is a progressive neurodegenerative disease characterized by damage to the optic nerve that results in irreversible vision loss. While the exact pathology of glaucoma is not well understood, emerging evidence suggests that dysregulation of the complement system, a key component of innate immunity, plays a crucial role. In glaucoma, dysregulation of the complement cascade and impaired regulation of complement factors contribute to chronic inflammation and neurodegeneration. Complement components such as C1Q, C3, and the membrane attack complex have been implicated in glaucomatous neuroinflammation and retinal ganglion cell death. This review will provide a summary of human and experimental studies that document the dysregulation of the complement system observed in glaucoma patients and animal models of glaucoma driving chronic inflammation and neurodegeneration. Understanding how complement-mediated damage contributes to glaucoma will provide opportunities for new therapies.https://www.mdpi.com/1422-0067/25/4/2307glaucomacomplement systeminflammation |
| spellingShingle | Cindy Hoppe Meredith Gregory-Ksander The Role of Complement Dysregulation in Glaucoma International Journal of Molecular Sciences glaucoma complement system inflammation |
| title | The Role of Complement Dysregulation in Glaucoma |
| title_full | The Role of Complement Dysregulation in Glaucoma |
| title_fullStr | The Role of Complement Dysregulation in Glaucoma |
| title_full_unstemmed | The Role of Complement Dysregulation in Glaucoma |
| title_short | The Role of Complement Dysregulation in Glaucoma |
| title_sort | role of complement dysregulation in glaucoma |
| topic | glaucoma complement system inflammation |
| url | https://www.mdpi.com/1422-0067/25/4/2307 |
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