1,5-Anhydroglucitol as a Useful Marker for Assessing Short-Term Glycemic Excursions in Type 1 Diabetes
BackgroundType 1 diabetes is associated with more severe glycemic variability and more frequent hypoglycemia than type 2 diabetes. Glycemic variability is associated with poor glycemic control and diabetic complications. In this study, we demonstrate the clinical usefulness of serum 1,5-anhydrogluci...
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| Format: | Article |
| Language: | English |
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Korean Diabetes Association
2015-04-01
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| Series: | Diabetes & Metabolism Journal |
| Subjects: | |
| Online Access: | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-39-164.pdf |
| _version_ | 1811200473625001984 |
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| author | Hannah Seok Ji Hye Huh Hyun Min Kim Byung-Wan Lee Eun Seok Kang Hyun Chul Lee Bong Soo Cha |
| author_facet | Hannah Seok Ji Hye Huh Hyun Min Kim Byung-Wan Lee Eun Seok Kang Hyun Chul Lee Bong Soo Cha |
| author_sort | Hannah Seok |
| collection | DOAJ |
| description | BackgroundType 1 diabetes is associated with more severe glycemic variability and more frequent hypoglycemia than type 2 diabetes. Glycemic variability is associated with poor glycemic control and diabetic complications. In this study, we demonstrate the clinical usefulness of serum 1,5-anhydroglucitol (1,5-AG) for assessing changes in glycemic excursion in type 1 diabetes.MethodsSeventeen patients with type 1 diabetes were enrolled in this study. A continuous glucose monitoring system (CGMS) was applied twice at a 2-week interval to evaluate changes in glycemic variability. The changes in serum glycemic assays, including 1,5-AG, glycated albumin and hemoglobin A1c (HbA1c), were also evaluated.ResultsMost subjects showed severe glycemic excursions, including hypoglycemia and hyperglycemia. The change in 1,5-AG level was significantly correlated with changes in the glycemic excursion indices of the standard deviation (SD), mean amplitude of glucose excursion (MAGE), lability index, mean postmeal maximum glucose, and area under the curve for glucose above 180 mg/dL (r=-0.576, -0.613, -0.600, -0.630, and -0.500, respectively; all P<0.05). Changes in glycated albumin were correlated with changes in SD and MAGE (r=0.495 and 0.517, respectively; all P<0.05). However, changes in HbA1c were not correlated with any changes in the CGMS variables.Conclusion1,5-AG may be a useful marker for the assessment of short-term changes in glycemic variability. Furthermore, 1,5-AG may have clinical implications for the evaluation and treatment of glycemic excursions in type 1 diabetes. |
| first_indexed | 2024-04-12T02:04:50Z |
| format | Article |
| id | doaj.art-b674bc3a977942eaa2aec530a308dbe3 |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-04-12T02:04:50Z |
| publishDate | 2015-04-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-b674bc3a977942eaa2aec530a308dbe32022-12-22T03:52:34ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872015-04-0139216417010.4093/dmj.2015.39.2.164146741,5-Anhydroglucitol as a Useful Marker for Assessing Short-Term Glycemic Excursions in Type 1 DiabetesHannah SeokJi Hye HuhHyun Min KimByung-Wan LeeEun Seok KangHyun Chul LeeBong Soo ChaBackgroundType 1 diabetes is associated with more severe glycemic variability and more frequent hypoglycemia than type 2 diabetes. Glycemic variability is associated with poor glycemic control and diabetic complications. In this study, we demonstrate the clinical usefulness of serum 1,5-anhydroglucitol (1,5-AG) for assessing changes in glycemic excursion in type 1 diabetes.MethodsSeventeen patients with type 1 diabetes were enrolled in this study. A continuous glucose monitoring system (CGMS) was applied twice at a 2-week interval to evaluate changes in glycemic variability. The changes in serum glycemic assays, including 1,5-AG, glycated albumin and hemoglobin A1c (HbA1c), were also evaluated.ResultsMost subjects showed severe glycemic excursions, including hypoglycemia and hyperglycemia. The change in 1,5-AG level was significantly correlated with changes in the glycemic excursion indices of the standard deviation (SD), mean amplitude of glucose excursion (MAGE), lability index, mean postmeal maximum glucose, and area under the curve for glucose above 180 mg/dL (r=-0.576, -0.613, -0.600, -0.630, and -0.500, respectively; all P<0.05). Changes in glycated albumin were correlated with changes in SD and MAGE (r=0.495 and 0.517, respectively; all P<0.05). However, changes in HbA1c were not correlated with any changes in the CGMS variables.Conclusion1,5-AG may be a useful marker for the assessment of short-term changes in glycemic variability. Furthermore, 1,5-AG may have clinical implications for the evaluation and treatment of glycemic excursions in type 1 diabetes.http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-39-164.pdf1,5-anhydroglucitolContinuous glucose monitoringType 1 diabetesGlycemic variability |
| spellingShingle | Hannah Seok Ji Hye Huh Hyun Min Kim Byung-Wan Lee Eun Seok Kang Hyun Chul Lee Bong Soo Cha 1,5-Anhydroglucitol as a Useful Marker for Assessing Short-Term Glycemic Excursions in Type 1 Diabetes Diabetes & Metabolism Journal 1,5-anhydroglucitol Continuous glucose monitoring Type 1 diabetes Glycemic variability |
| title | 1,5-Anhydroglucitol as a Useful Marker for Assessing Short-Term Glycemic Excursions in Type 1 Diabetes |
| title_full | 1,5-Anhydroglucitol as a Useful Marker for Assessing Short-Term Glycemic Excursions in Type 1 Diabetes |
| title_fullStr | 1,5-Anhydroglucitol as a Useful Marker for Assessing Short-Term Glycemic Excursions in Type 1 Diabetes |
| title_full_unstemmed | 1,5-Anhydroglucitol as a Useful Marker for Assessing Short-Term Glycemic Excursions in Type 1 Diabetes |
| title_short | 1,5-Anhydroglucitol as a Useful Marker for Assessing Short-Term Glycemic Excursions in Type 1 Diabetes |
| title_sort | 1 5 anhydroglucitol as a useful marker for assessing short term glycemic excursions in type 1 diabetes |
| topic | 1,5-anhydroglucitol Continuous glucose monitoring Type 1 diabetes Glycemic variability |
| url | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-39-164.pdf |
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