Frequency and Prognostic Significance of Intertumoural Heterogeneity in Multifocal Jejunoileal Neuroendocrine Tumours
Background: A recent study found that multifocal jejunoileal neuroendocrine tumors (SI-NETs) are genetically unrelated synchronous neoplasms. So far, it is unclear if this finding of synchronous independent neoplasms is mirrored by heterogeneity of key morphological parameters of SI-NETs and how it...
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MDPI AG
2022-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/16/3963 |
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| author | Moritz Jesinghaus Jelte Poppinga Bettina Lehman Elisabeth Maurer Annette Ramaswamy Albert Grass Pietro Di Fazio Anja Rinke Carsten Denkert Detlef K. Bartsch |
| author_facet | Moritz Jesinghaus Jelte Poppinga Bettina Lehman Elisabeth Maurer Annette Ramaswamy Albert Grass Pietro Di Fazio Anja Rinke Carsten Denkert Detlef K. Bartsch |
| author_sort | Moritz Jesinghaus |
| collection | DOAJ |
| description | Background: A recent study found that multifocal jejunoileal neuroendocrine tumors (SI-NETs) are genetically unrelated synchronous neoplasms. So far, it is unclear if this finding of synchronous independent neoplasms is mirrored by heterogeneity of key morphological parameters of SI-NETs and how it affects patient survival. Methods: We separately assessed WHO grade (based on the Ki-67 index), expression of basal diagnostic markers (synaptophysin/chromogranin A/CDX2/serotonin), SSTR2a, and the contexture of the immunogenic microenvironment in 146 separate tumors from 28 patients with multifocal SI-NETs and correlated the results with clinicopathological factors and survival. Results: Synaptophysin and chromogranin A were strongly expressed in all tumors. WHO grade was concordant within all multifocal lesions in more than 80% of cases and the highest grade was usually found in the most advanced primary. Intertumoral expression of serotonin, SSTR2, and CDX2 was discrepant in 32%, 43%, and 50% of all patients, respectively. Neither heterogeneity of any of the aforementioned markers nor multifocality itself had any impact on patient survival (<i>p</i> = n.s.). Discussion: Multifocal SI-NET show considerable variability in some of the central diagnostic parameters. However, neither intertumoral heterogeneity of those parameters nor multifocality itself had any impact on patient survival, showing that extensive testing of all multifocal lesions is not necessarily required. |
| first_indexed | 2024-03-09T04:38:23Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T04:38:23Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b6752d19f48547a2bcd821d3607e66102023-12-03T13:25:14ZengMDPI AGCancers2072-66942022-08-011416396310.3390/cancers14163963Frequency and Prognostic Significance of Intertumoural Heterogeneity in Multifocal Jejunoileal Neuroendocrine TumoursMoritz Jesinghaus0Jelte Poppinga1Bettina Lehman2Elisabeth Maurer3Annette Ramaswamy4Albert Grass5Pietro Di Fazio6Anja Rinke7Carsten Denkert8Detlef K. Bartsch9Institute of Pathology, Phillips University Marburg and University Hospital Marburg, 35043 Marburg, GermanyDepartment of Visceral, Thoracic and Vascular Surgery, Phillips University Marburg and University Hospital Marburg, 35043 Marburg, GermanyDepartment of Visceral, Thoracic and Vascular Surgery, Phillips University Marburg and University Hospital Marburg, 35043 Marburg, GermanyDepartment of Visceral, Thoracic and Vascular Surgery, Phillips University Marburg and University Hospital Marburg, 35043 Marburg, GermanyInstitute of Pathology, Phillips University Marburg and University Hospital Marburg, 35043 Marburg, GermanyInstitute of Pathology, Phillips University Marburg and University Hospital Marburg, 35043 Marburg, GermanyDepartment of Visceral, Thoracic and Vascular Surgery, Phillips University Marburg and University Hospital Marburg, 35043 Marburg, GermanyDepartment of Gastroenterology, Phillips University Marburg and University Hospital Marburg, 35043 Marburg, GermanyInstitute of Pathology, Phillips University Marburg and University Hospital Marburg, 35043 Marburg, GermanyDepartment of Visceral, Thoracic and Vascular Surgery, Phillips University Marburg and University Hospital Marburg, 35043 Marburg, GermanyBackground: A recent study found that multifocal jejunoileal neuroendocrine tumors (SI-NETs) are genetically unrelated synchronous neoplasms. So far, it is unclear if this finding of synchronous independent neoplasms is mirrored by heterogeneity of key morphological parameters of SI-NETs and how it affects patient survival. Methods: We separately assessed WHO grade (based on the Ki-67 index), expression of basal diagnostic markers (synaptophysin/chromogranin A/CDX2/serotonin), SSTR2a, and the contexture of the immunogenic microenvironment in 146 separate tumors from 28 patients with multifocal SI-NETs and correlated the results with clinicopathological factors and survival. Results: Synaptophysin and chromogranin A were strongly expressed in all tumors. WHO grade was concordant within all multifocal lesions in more than 80% of cases and the highest grade was usually found in the most advanced primary. Intertumoral expression of serotonin, SSTR2, and CDX2 was discrepant in 32%, 43%, and 50% of all patients, respectively. Neither heterogeneity of any of the aforementioned markers nor multifocality itself had any impact on patient survival (<i>p</i> = n.s.). Discussion: Multifocal SI-NET show considerable variability in some of the central diagnostic parameters. However, neither intertumoral heterogeneity of those parameters nor multifocality itself had any impact on patient survival, showing that extensive testing of all multifocal lesions is not necessarily required.https://www.mdpi.com/2072-6694/14/16/3963multifocal neuroendocrine tumorsSI-NETsintertumoral heterogeneity |
| spellingShingle | Moritz Jesinghaus Jelte Poppinga Bettina Lehman Elisabeth Maurer Annette Ramaswamy Albert Grass Pietro Di Fazio Anja Rinke Carsten Denkert Detlef K. Bartsch Frequency and Prognostic Significance of Intertumoural Heterogeneity in Multifocal Jejunoileal Neuroendocrine Tumours Cancers multifocal neuroendocrine tumors SI-NETs intertumoral heterogeneity |
| title | Frequency and Prognostic Significance of Intertumoural Heterogeneity in Multifocal Jejunoileal Neuroendocrine Tumours |
| title_full | Frequency and Prognostic Significance of Intertumoural Heterogeneity in Multifocal Jejunoileal Neuroendocrine Tumours |
| title_fullStr | Frequency and Prognostic Significance of Intertumoural Heterogeneity in Multifocal Jejunoileal Neuroendocrine Tumours |
| title_full_unstemmed | Frequency and Prognostic Significance of Intertumoural Heterogeneity in Multifocal Jejunoileal Neuroendocrine Tumours |
| title_short | Frequency and Prognostic Significance of Intertumoural Heterogeneity in Multifocal Jejunoileal Neuroendocrine Tumours |
| title_sort | frequency and prognostic significance of intertumoural heterogeneity in multifocal jejunoileal neuroendocrine tumours |
| topic | multifocal neuroendocrine tumors SI-NETs intertumoral heterogeneity |
| url | https://www.mdpi.com/2072-6694/14/16/3963 |
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