Comparison of Certain Intrarectal versus Intramuscular Pharmacodynamic Effects of Ketamine, Dexmedetomidine and Midazolam in Cats
The aim of this clinical trial was to evaluate the impacts of administration via the intrarectal route (IR) in cats on their heart and respiratory rates, blood pressure, body temperature, and sedation quality compared to the intramuscular route (IM). The intramuscular group (IMG) received 0.003 mg k...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/9/10/520 |
| _version_ | 1797469653013889024 |
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| author | Andrea Paolini Massimo Vignoli Giulia Guerri Ilaria Falerno Roberto Tamburro Francesco Simeoni Francesca Del Signore Andrea De Bonis Francesco Collivignarelli Maria Cristina Salvo Ilaria Cerasoli |
| author_facet | Andrea Paolini Massimo Vignoli Giulia Guerri Ilaria Falerno Roberto Tamburro Francesco Simeoni Francesca Del Signore Andrea De Bonis Francesco Collivignarelli Maria Cristina Salvo Ilaria Cerasoli |
| author_sort | Andrea Paolini |
| collection | DOAJ |
| description | The aim of this clinical trial was to evaluate the impacts of administration via the intrarectal route (IR) in cats on their heart and respiratory rates, blood pressure, body temperature, and sedation quality compared to the intramuscular route (IM). The intramuscular group (IMG) received 0.003 mg kg<sup>−1</sup> dexmedetomidine, 2 mg kg<sup>−1</sup> ketamine, and 0.2 mg kg<sup>−1</sup> midazolam while the intrarectal group (IRG) protocol was 0.003 mg kg<sup>−1</sup> dexmedetomidine, 4 mg kg<sup>−1</sup> ketamine, and 0.4 mg kg<sup>−1</sup> midazolam. Cardiorespiratory values, temperature, and sedation score were measured 2 min after administration and then every 5 min up to the 40th minute. Cats belonging to IRG reacted less strongly to the drug, as opposed to those receiving intramuscular administration (2/10 in IRG vs. 8/10 in IMG). Average time between drug administration and standing position was 44.9 ± 5.79 in IRG and 57 ± 9.88 min in IMG. In IRG, maintenance of SpO₂ values is >95% at each time point. Median and range peak of sedation {7 (5)} in IMG occurs at 20th, 25th, and 30th minutes post drug administration while was lower in IRG. Cardiorespiratory values were slightly lower in IMG than in IRG, but always constant in both treatments. Temperature did not differ between groups. At this dosage, although sedation score was higher in IMG, intrarectal route could be efficacious for performing minimally invasive clinical and diagnostic procedures in cats. |
| first_indexed | 2024-03-09T19:24:14Z |
| format | Article |
| id | doaj.art-b67898db6829434eb1068d97b96bdec9 |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-09T19:24:14Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-b67898db6829434eb1068d97b96bdec92023-11-24T03:06:00ZengMDPI AGVeterinary Sciences2306-73812022-09-0191052010.3390/vetsci9100520Comparison of Certain Intrarectal versus Intramuscular Pharmacodynamic Effects of Ketamine, Dexmedetomidine and Midazolam in CatsAndrea Paolini0Massimo Vignoli1Giulia Guerri2Ilaria Falerno3Roberto Tamburro4Francesco Simeoni5Francesca Del Signore6Andrea De Bonis7Francesco Collivignarelli8Maria Cristina Salvo9Ilaria Cerasoli10Faculty of Veterinary Medicine, University of Teramo, Località Piano D’Accio, 64100 Teramo, ItalyFaculty of Veterinary Medicine, University of Teramo, Località Piano D’Accio, 64100 Teramo, ItalyFaculty of Veterinary Medicine, University of Teramo, Località Piano D’Accio, 64100 Teramo, ItalyFaculty of Veterinary Medicine, University of Teramo, Località Piano D’Accio, 64100 Teramo, ItalyFaculty of Veterinary Medicine, University of Teramo, Località Piano D’Accio, 64100 Teramo, ItalyFaculty of Veterinary Medicine, University of Teramo, Località Piano D’Accio, 64100 Teramo, ItalyFaculty of Veterinary Medicine, University of Teramo, Località Piano D’Accio, 64100 Teramo, ItalyFaculty of Veterinary Medicine, University of Teramo, Località Piano D’Accio, 64100 Teramo, ItalyFaculty of Veterinary Medicine, University of Teramo, Località Piano D’Accio, 64100 Teramo, ItalyFaculty of Veterinary Medicine, University of Teramo, Località Piano D’Accio, 64100 Teramo, ItalyClinica Veterinaria Borghesiana, 00132 Rome, ItalyThe aim of this clinical trial was to evaluate the impacts of administration via the intrarectal route (IR) in cats on their heart and respiratory rates, blood pressure, body temperature, and sedation quality compared to the intramuscular route (IM). The intramuscular group (IMG) received 0.003 mg kg<sup>−1</sup> dexmedetomidine, 2 mg kg<sup>−1</sup> ketamine, and 0.2 mg kg<sup>−1</sup> midazolam while the intrarectal group (IRG) protocol was 0.003 mg kg<sup>−1</sup> dexmedetomidine, 4 mg kg<sup>−1</sup> ketamine, and 0.4 mg kg<sup>−1</sup> midazolam. Cardiorespiratory values, temperature, and sedation score were measured 2 min after administration and then every 5 min up to the 40th minute. Cats belonging to IRG reacted less strongly to the drug, as opposed to those receiving intramuscular administration (2/10 in IRG vs. 8/10 in IMG). Average time between drug administration and standing position was 44.9 ± 5.79 in IRG and 57 ± 9.88 min in IMG. In IRG, maintenance of SpO₂ values is >95% at each time point. Median and range peak of sedation {7 (5)} in IMG occurs at 20th, 25th, and 30th minutes post drug administration while was lower in IRG. Cardiorespiratory values were slightly lower in IMG than in IRG, but always constant in both treatments. Temperature did not differ between groups. At this dosage, although sedation score was higher in IMG, intrarectal route could be efficacious for performing minimally invasive clinical and diagnostic procedures in cats.https://www.mdpi.com/2306-7381/9/10/520catsintrarectal routeintramuscular routedexmedetomidineketaminemidazolam |
| spellingShingle | Andrea Paolini Massimo Vignoli Giulia Guerri Ilaria Falerno Roberto Tamburro Francesco Simeoni Francesca Del Signore Andrea De Bonis Francesco Collivignarelli Maria Cristina Salvo Ilaria Cerasoli Comparison of Certain Intrarectal versus Intramuscular Pharmacodynamic Effects of Ketamine, Dexmedetomidine and Midazolam in Cats Veterinary Sciences cats intrarectal route intramuscular route dexmedetomidine ketamine midazolam |
| title | Comparison of Certain Intrarectal versus Intramuscular Pharmacodynamic Effects of Ketamine, Dexmedetomidine and Midazolam in Cats |
| title_full | Comparison of Certain Intrarectal versus Intramuscular Pharmacodynamic Effects of Ketamine, Dexmedetomidine and Midazolam in Cats |
| title_fullStr | Comparison of Certain Intrarectal versus Intramuscular Pharmacodynamic Effects of Ketamine, Dexmedetomidine and Midazolam in Cats |
| title_full_unstemmed | Comparison of Certain Intrarectal versus Intramuscular Pharmacodynamic Effects of Ketamine, Dexmedetomidine and Midazolam in Cats |
| title_short | Comparison of Certain Intrarectal versus Intramuscular Pharmacodynamic Effects of Ketamine, Dexmedetomidine and Midazolam in Cats |
| title_sort | comparison of certain intrarectal versus intramuscular pharmacodynamic effects of ketamine dexmedetomidine and midazolam in cats |
| topic | cats intrarectal route intramuscular route dexmedetomidine ketamine midazolam |
| url | https://www.mdpi.com/2306-7381/9/10/520 |
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