Animal protein intake is directly associated with serum level of pentraxin 3 in hemodialysis patients
Abstract Inflammation plays an important role in Cardiovascular disease (CVD) pathogenesis as the main cause of mortality in hemodialysis (HD) patients. Despite the relevance of nutrition and dietary intakes for inflammation status, the role of dietary protein sources remains unclear. The aim of thi...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-48671-8 |
| _version_ | 1827590583305109504 |
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| author | Fatemeh Navab Sahar Foshati Mohammad Bagherniya Gholamreza Askari Firouzeh Moeinzadeh Alieh Gholaminejad Cain C. T. Clark Mohammad Hossein Rouhani |
| author_facet | Fatemeh Navab Sahar Foshati Mohammad Bagherniya Gholamreza Askari Firouzeh Moeinzadeh Alieh Gholaminejad Cain C. T. Clark Mohammad Hossein Rouhani |
| author_sort | Fatemeh Navab |
| collection | DOAJ |
| description | Abstract Inflammation plays an important role in Cardiovascular disease (CVD) pathogenesis as the main cause of mortality in hemodialysis (HD) patients. Despite the relevance of nutrition and dietary intakes for inflammation status, the role of dietary protein sources remains unclear. The aim of this study was to evaluate the association between the different types of dietary protein and pentraxin 3 (PTX3) levels in HD patients. In this multi-center cross-sectional study, 227 adult patients undergoing HD for a minimum 90 days were recruited. A validated 168-item food frequency questionnaire was used to assess dietary intakes. Also, 5 ml blood samples were collected from each patient to measure the concentration of serum PTX3. Overall, 227 patients, including 63 women and 164 men, with a mean age of 58 years, participated in this study. There was a greater intake of animal protein per kilogram dry weight among patients with higher levels of PTX3 (0.46 vs. 0.54 g/kg; P = 0.035). In contrast, consumption of total protein and plant protein per kilogram dry weight was not different across PTX3 levels. Moreover, the chance of increased PTX3 concentration was directly associated with a one-unit increase in animal protein intake per kilogram dry weight, after adjusting for confounders. We did not observe any association between one-unit increases in plant protein intake per kilogram dry weight and chance of increased PTX3. In conclusion, animal protein intake was directly associated with circulating PTX3. |
| first_indexed | 2024-03-09T01:18:52Z |
| format | Article |
| id | doaj.art-b6792e5f674e42ffaa5aff1d5a0e8b24 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T01:18:52Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b6792e5f674e42ffaa5aff1d5a0e8b242023-12-10T12:17:08ZengNature PortfolioScientific Reports2045-23222023-12-011311810.1038/s41598-023-48671-8Animal protein intake is directly associated with serum level of pentraxin 3 in hemodialysis patientsFatemeh Navab0Sahar Foshati1Mohammad Bagherniya2Gholamreza Askari3Firouzeh Moeinzadeh4Alieh Gholaminejad5Cain C. T. Clark6Mohammad Hossein Rouhani7Nutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical SciencesNutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical SciencesNutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical SciencesNutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical SciencesIsfahan Kidney Diseases Research Center, Isfahan University of Medical SciencesRegenerative Medicine Research Center, Faculty of Medicine, Isfahan University of Medical SciencesCentre for Intelligent Healthcare, Coventry UniversityNutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical SciencesAbstract Inflammation plays an important role in Cardiovascular disease (CVD) pathogenesis as the main cause of mortality in hemodialysis (HD) patients. Despite the relevance of nutrition and dietary intakes for inflammation status, the role of dietary protein sources remains unclear. The aim of this study was to evaluate the association between the different types of dietary protein and pentraxin 3 (PTX3) levels in HD patients. In this multi-center cross-sectional study, 227 adult patients undergoing HD for a minimum 90 days were recruited. A validated 168-item food frequency questionnaire was used to assess dietary intakes. Also, 5 ml blood samples were collected from each patient to measure the concentration of serum PTX3. Overall, 227 patients, including 63 women and 164 men, with a mean age of 58 years, participated in this study. There was a greater intake of animal protein per kilogram dry weight among patients with higher levels of PTX3 (0.46 vs. 0.54 g/kg; P = 0.035). In contrast, consumption of total protein and plant protein per kilogram dry weight was not different across PTX3 levels. Moreover, the chance of increased PTX3 concentration was directly associated with a one-unit increase in animal protein intake per kilogram dry weight, after adjusting for confounders. We did not observe any association between one-unit increases in plant protein intake per kilogram dry weight and chance of increased PTX3. In conclusion, animal protein intake was directly associated with circulating PTX3.https://doi.org/10.1038/s41598-023-48671-8 |
| spellingShingle | Fatemeh Navab Sahar Foshati Mohammad Bagherniya Gholamreza Askari Firouzeh Moeinzadeh Alieh Gholaminejad Cain C. T. Clark Mohammad Hossein Rouhani Animal protein intake is directly associated with serum level of pentraxin 3 in hemodialysis patients Scientific Reports |
| title | Animal protein intake is directly associated with serum level of pentraxin 3 in hemodialysis patients |
| title_full | Animal protein intake is directly associated with serum level of pentraxin 3 in hemodialysis patients |
| title_fullStr | Animal protein intake is directly associated with serum level of pentraxin 3 in hemodialysis patients |
| title_full_unstemmed | Animal protein intake is directly associated with serum level of pentraxin 3 in hemodialysis patients |
| title_short | Animal protein intake is directly associated with serum level of pentraxin 3 in hemodialysis patients |
| title_sort | animal protein intake is directly associated with serum level of pentraxin 3 in hemodialysis patients |
| url | https://doi.org/10.1038/s41598-023-48671-8 |
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