Collapsing Glomerulopathy: A Single Centre Clinicopathologic Study of Seven Years
Introduction: Collapsing Glomerulopathy (CG) is recognized as distinct pattern of proliferative parenchymal injury with poor response to empirical therapy. Aim: A single center retrospective study was carried out to find out clinicopathological features of idiopathic CG. Materials and Methods:...
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JCDR Research and Publications Private Limited
2016-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| author | Kamal V. Kanodia Aruna V. Vanikar Rashmi D. Patel Kamlesh S. Suthar Lovelesh K. Nigam Himanshu V. Patel Vivek Kute Hargovind L. Trivedi |
| author_facet | Kamal V. Kanodia Aruna V. Vanikar Rashmi D. Patel Kamlesh S. Suthar Lovelesh K. Nigam Himanshu V. Patel Vivek Kute Hargovind L. Trivedi |
| author_sort | Kamal V. Kanodia |
| collection | DOAJ |
| description | Introduction: Collapsing Glomerulopathy (CG) is recognized
as distinct pattern of proliferative parenchymal injury with poor
response to empirical therapy.
Aim: A single center retrospective study was carried out to find
out clinicopathological features of idiopathic CG.
Materials and Methods: A total of 3335 native renal biopsies
were analyzed retrospectively which were performed from 2008
to 2014 with emphasis on clinicopathological correlation and
histopathological presentation.
Results: Idiopathic CG constituted 0.75% incidence (25 out of
3335 biopsies) of all biopsies, adults constituting major study
part with 88%. The duration of the symptoms at the time of
biopsy was 34.12±26.09 days and 35±22.91 days respectively
in adults and children. Hypertension was noted in 9(40.9%) and
oliguria in 8(36.4%) in adults. Urinalysis revealed microscopic
haematuria 12(54.5%) in adults. Nephrotic range proteinuria
was reported in 10 (45.5%) adult patients. Glomerular collapse
with hyperplasia/ hypertrophy of podocytes was seen in
4.54±3.11 glomeruli. Tubular microcystic dilation was seen in
16(64%) patients. Tubular atrophy involving mild (t1
) in 15(60%),
moderate (t2
) in 4(16%) and severe (t3
) in 6(24%) patients.
Interstitial fibrosis was mild (i1
) in 17(68%), moderate (i2
) in 2(8%)
and severe (i3) in 6(24%) patients.
Conclusion: Idiopathic CG is a morphological pattern of
grave podocyte injury with poor prognosis. However, there
are chances of remission/ recovery if the tubular atrophy and
interstitial fibrosis are of grades ≤ t1
i1 |
| first_indexed | 2024-12-22T22:47:31Z |
| format | Article |
| id | doaj.art-b67947cc9d5b433999dac9f943504306 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-22T22:47:31Z |
| publishDate | 2016-04-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-b67947cc9d5b433999dac9f9435043062022-12-21T18:10:02ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-04-01104EC15EC1710.7860/JCDR/2016/17297.7646Collapsing Glomerulopathy: A Single Centre Clinicopathologic Study of Seven YearsKamal V. Kanodia0Aruna V. Vanikar1Rashmi D. Patel2Kamlesh S. Suthar3Lovelesh K. Nigam4Himanshu V. Patel5Vivek Kute6Hargovind L. Trivedi7Professor, Department of Pathology, Lab Medicine, Transfusion Services and Immunohematology, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, India.Professor and Head, Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, India.Professor, Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, India.Associate Professor, Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, India.Associate Professor, Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, India.Professor, Department of Nephrology and Transplantation, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, India.Associate Professor, Department of Nephrology and Transplantation, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, India.Professor, Department of Nephrology and Transplantation Medicine and Director, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, India.Introduction: Collapsing Glomerulopathy (CG) is recognized as distinct pattern of proliferative parenchymal injury with poor response to empirical therapy. Aim: A single center retrospective study was carried out to find out clinicopathological features of idiopathic CG. Materials and Methods: A total of 3335 native renal biopsies were analyzed retrospectively which were performed from 2008 to 2014 with emphasis on clinicopathological correlation and histopathological presentation. Results: Idiopathic CG constituted 0.75% incidence (25 out of 3335 biopsies) of all biopsies, adults constituting major study part with 88%. The duration of the symptoms at the time of biopsy was 34.12±26.09 days and 35±22.91 days respectively in adults and children. Hypertension was noted in 9(40.9%) and oliguria in 8(36.4%) in adults. Urinalysis revealed microscopic haematuria 12(54.5%) in adults. Nephrotic range proteinuria was reported in 10 (45.5%) adult patients. Glomerular collapse with hyperplasia/ hypertrophy of podocytes was seen in 4.54±3.11 glomeruli. Tubular microcystic dilation was seen in 16(64%) patients. Tubular atrophy involving mild (t1 ) in 15(60%), moderate (t2 ) in 4(16%) and severe (t3 ) in 6(24%) patients. Interstitial fibrosis was mild (i1 ) in 17(68%), moderate (i2 ) in 2(8%) and severe (i3) in 6(24%) patients. Conclusion: Idiopathic CG is a morphological pattern of grave podocyte injury with poor prognosis. However, there are chances of remission/ recovery if the tubular atrophy and interstitial fibrosis are of grades ≤ t1 i1https://jcdr.net/articles/PDF/7646/17297_CE(RA1)_F(T)_PF1(RSAK)_PFA(AK)_PF2(PAG).pdfend stage renal diseaseidiopathic collapsing glomerulopathyproteinuriapodocyte |
| spellingShingle | Kamal V. Kanodia Aruna V. Vanikar Rashmi D. Patel Kamlesh S. Suthar Lovelesh K. Nigam Himanshu V. Patel Vivek Kute Hargovind L. Trivedi Collapsing Glomerulopathy: A Single Centre Clinicopathologic Study of Seven Years Journal of Clinical and Diagnostic Research end stage renal disease idiopathic collapsing glomerulopathy proteinuria podocyte |
| title | Collapsing Glomerulopathy: A Single Centre Clinicopathologic Study of Seven Years |
| title_full | Collapsing Glomerulopathy: A Single Centre Clinicopathologic Study of Seven Years |
| title_fullStr | Collapsing Glomerulopathy: A Single Centre Clinicopathologic Study of Seven Years |
| title_full_unstemmed | Collapsing Glomerulopathy: A Single Centre Clinicopathologic Study of Seven Years |
| title_short | Collapsing Glomerulopathy: A Single Centre Clinicopathologic Study of Seven Years |
| title_sort | collapsing glomerulopathy a single centre clinicopathologic study of seven years |
| topic | end stage renal disease idiopathic collapsing glomerulopathy proteinuria podocyte |
| url | https://jcdr.net/articles/PDF/7646/17297_CE(RA1)_F(T)_PF1(RSAK)_PFA(AK)_PF2(PAG).pdf |
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