Neuromyelitis optica - an update: 2007-2009
Neuromyelitis optica is an inflammatory demyelinating disorder of the central nervous system. The discovery of a specific antibody (NMO IgG /aquaporin-4 antibody) in patients with this condition has led to a marked revival of research on the disease. This article summarizes the major advances in neu...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2009-01-01
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| Series: | Annals of Indian Academy of Neurology |
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| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2009;volume=12;issue=4;spage=231;epage=237;aulast=Jacob |
| _version_ | 1811206880067846144 |
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| author | Jacob Anu |
| author_facet | Jacob Anu |
| author_sort | Jacob Anu |
| collection | DOAJ |
| description | Neuromyelitis optica is an inflammatory demyelinating disorder of the central nervous system. The discovery of a specific antibody (NMO IgG /aquaporin-4 antibody) in patients with this condition has led to a marked revival of research on the disease. This article summarizes the major advances in neuromyelitis optica, particularly in the last 2 years, and supplements the previous review published in this Journal in 2007. Important among these developments are: the epidemiological studies, which have provided estimates of incidence and prevalence; identification of mutations in the aquaporin-4 gene; improved understanding of the effects of anti-aquaporin-4 antibody on astrocytes; roles of excitatory amino acid transporter type 2 and glutamate; requirement of aquaporin-4 to be in orthogonal arrays to be antigenic; recognition of the presence of aquaporin-4 antibody in patients with cancer and posterior reversible encephalopathy syndrome; possibility of monitoring the disease using the antibody, and the effectiveness of rituximab and mycophenolate in preventing relapses. |
| first_indexed | 2024-04-12T03:54:17Z |
| format | Article |
| id | doaj.art-b67b184fd2f745498f253c914bc7ef3c |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-04-12T03:54:17Z |
| publishDate | 2009-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-b67b184fd2f745498f253c914bc7ef3c2022-12-22T03:48:53ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492009-01-01124231237Neuromyelitis optica - an update: 2007-2009Jacob AnuNeuromyelitis optica is an inflammatory demyelinating disorder of the central nervous system. The discovery of a specific antibody (NMO IgG /aquaporin-4 antibody) in patients with this condition has led to a marked revival of research on the disease. This article summarizes the major advances in neuromyelitis optica, particularly in the last 2 years, and supplements the previous review published in this Journal in 2007. Important among these developments are: the epidemiological studies, which have provided estimates of incidence and prevalence; identification of mutations in the aquaporin-4 gene; improved understanding of the effects of anti-aquaporin-4 antibody on astrocytes; roles of excitatory amino acid transporter type 2 and glutamate; requirement of aquaporin-4 to be in orthogonal arrays to be antigenic; recognition of the presence of aquaporin-4 antibody in patients with cancer and posterior reversible encephalopathy syndrome; possibility of monitoring the disease using the antibody, and the effectiveness of rituximab and mycophenolate in preventing relapses.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2009;volume=12;issue=4;spage=231;epage=237;aulast=JacobAquaporinmultiple sclerosismyelitisneuromyelitis optica |
| spellingShingle | Jacob Anu Neuromyelitis optica - an update: 2007-2009 Annals of Indian Academy of Neurology Aquaporin multiple sclerosis myelitis neuromyelitis optica |
| title | Neuromyelitis optica - an update: 2007-2009 |
| title_full | Neuromyelitis optica - an update: 2007-2009 |
| title_fullStr | Neuromyelitis optica - an update: 2007-2009 |
| title_full_unstemmed | Neuromyelitis optica - an update: 2007-2009 |
| title_short | Neuromyelitis optica - an update: 2007-2009 |
| title_sort | neuromyelitis optica an update 2007 2009 |
| topic | Aquaporin multiple sclerosis myelitis neuromyelitis optica |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2009;volume=12;issue=4;spage=231;epage=237;aulast=Jacob |
| work_keys_str_mv | AT jacobanu neuromyelitisopticaanupdate20072009 |