Six-Month Synbio<sup>®</sup> Administration Affects Nutritional and Inflammatory Parameters of Older Adults Included in the PROBIOSENIOR Project
The physiological changes associated with ageing contribute to the incidence of diseases, morbidity, and mortality. For modern society, it is essential to find solutions to improve elderly people’s health and quality of life. Among promising strategies, the PROBIOSENIOR project proposed a daily six-...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/11/3/801 |
| _version_ | 1797610019327311872 |
|---|---|
| author | Chiara Salvesi Stefania Silvi Dennis Fiorini Laura Alessandroni Gianni Sagratini Francesco Alessandro Palermo Renato De Leone Nadaniela Egidi Carlo Cifani Maria Vittoria Micioni Di Bonaventura Amedeo Amedei Elena Niccolai Francesca Scocchera Fausto Mannucci Valerio Valeriani Marco Malavasi Sara Servili Andrea Casula Andrea Cresci Ivano Corradetti Maria Magdalena Coman M. Cristina Verdenelli |
| author_facet | Chiara Salvesi Stefania Silvi Dennis Fiorini Laura Alessandroni Gianni Sagratini Francesco Alessandro Palermo Renato De Leone Nadaniela Egidi Carlo Cifani Maria Vittoria Micioni Di Bonaventura Amedeo Amedei Elena Niccolai Francesca Scocchera Fausto Mannucci Valerio Valeriani Marco Malavasi Sara Servili Andrea Casula Andrea Cresci Ivano Corradetti Maria Magdalena Coman M. Cristina Verdenelli |
| author_sort | Chiara Salvesi |
| collection | DOAJ |
| description | The physiological changes associated with ageing contribute to the incidence of diseases, morbidity, and mortality. For modern society, it is essential to find solutions to improve elderly people’s health and quality of life. Among promising strategies, the PROBIOSENIOR project proposed a daily six-month supplementation with new probiotic functional foods and nutraceuticals. The aim of this work was to evaluate the modulating effects of the probiotic diet on inflammatory markers and nutritional status. Ninety-seven elderly volunteers were randomly assigned to either a placebo-diet group or a probiotic-diet group (SYNBIO<sup>®</sup>). Faeces, urine, and blood samples were collected before and after the supplementation to determine serum cytokines, biogenic amines, and inflammation markers. Comparing the results obtained before and after the intervention, probiotic supplementations significantly decreased the TNF-α circulating levels and significantly increased those of IGF-1. Biogenic-amine levels showed high variability, with significant variation only for histamine that decreased after the probiotic supplementation. The supplementation influenced the serum concentration of some crucial cytokines (IL-6, IL-8, and MIP-1α) that significantly decreased in the probiotic group. In addition, the Mini Nutritional Assessment questionnaire revealed that the probiotic-supplemented group had a significant improvement in nutritional status. In conclusion, the PROBIOSENIOR project demonstrated how SYNBIO<sup>®</sup> supplementation may positively influence some nutritional and inflammatory parameters in the elderly. |
| first_indexed | 2024-03-11T06:09:34Z |
| format | Article |
| id | doaj.art-b67cc3ef9e884676906fa188cfd17322 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-11T06:09:34Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-b67cc3ef9e884676906fa188cfd173222023-11-17T12:46:17ZengMDPI AGMicroorganisms2076-26072023-03-0111380110.3390/microorganisms11030801Six-Month Synbio<sup>®</sup> Administration Affects Nutritional and Inflammatory Parameters of Older Adults Included in the PROBIOSENIOR ProjectChiara Salvesi0Stefania Silvi1Dennis Fiorini2Laura Alessandroni3Gianni Sagratini4Francesco Alessandro Palermo5Renato De Leone6Nadaniela Egidi7Carlo Cifani8Maria Vittoria Micioni Di Bonaventura9Amedeo Amedei10Elena Niccolai11Francesca Scocchera12Fausto Mannucci13Valerio Valeriani14Marco Malavasi15Sara Servili16Andrea Casula17Andrea Cresci18Ivano Corradetti19Maria Magdalena Coman20M. Cristina Verdenelli21Scuola di Bioscienze e Medicina Veterinaria, University of Camerino, 62032 Camerino, ItalyScuola di Bioscienze e Medicina Veterinaria, University of Camerino, 62032 Camerino, ItalyScuola di Scienze e Tecnologie, University of Camerino, 62032 Camerino, ItalyScuola di Scienze del Farmaco e dei Prodotti della Salute, University of Camerino, 62032 Camerino, ItalyScuola di Scienze del Farmaco e dei Prodotti della Salute, University of Camerino, 62032 Camerino, ItalyScuola di Bioscienze e Medicina Veterinaria, University of Camerino, 62032 Camerino, ItalyScuola di Scienze e Tecnologie, University of Camerino, 62032 Camerino, ItalyScuola di Scienze e Tecnologie, University of Camerino, 62032 Camerino, ItalyScuola di Scienze del Farmaco e dei Prodotti della Salute, University of Camerino, 62032 Camerino, ItalyScuola di Scienze del Farmaco e dei Prodotti della Salute, University of Camerino, 62032 Camerino, ItalyDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, ItalyDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, ItalyCOOSS Marche Cooperativa Sociale Onlus, 60121 Ancona, ItalyLabor SPA, 60127 Ancona, ItalyAmbito Territoriale Sociale 16-17-18 Marche Region, 62032 Camerino, ItalyIT Innovative Technology S.r.l., 62032 Camerino, ItalyFidoka S.r.l., 62020 Ripe San Ginesio, ItalyCaseificio Val D’Apsa & C. Snc, 61029 Urbino, ItalySynbiofood S.r.l., 62012 Civitanova Marche, ItalyPartner S.r.l., 62078 Spinetoli, ItalySynbiotec S.r.l., 62032 Camerino, ItalySynbiotec S.r.l., 62032 Camerino, ItalyThe physiological changes associated with ageing contribute to the incidence of diseases, morbidity, and mortality. For modern society, it is essential to find solutions to improve elderly people’s health and quality of life. Among promising strategies, the PROBIOSENIOR project proposed a daily six-month supplementation with new probiotic functional foods and nutraceuticals. The aim of this work was to evaluate the modulating effects of the probiotic diet on inflammatory markers and nutritional status. Ninety-seven elderly volunteers were randomly assigned to either a placebo-diet group or a probiotic-diet group (SYNBIO<sup>®</sup>). Faeces, urine, and blood samples were collected before and after the supplementation to determine serum cytokines, biogenic amines, and inflammation markers. Comparing the results obtained before and after the intervention, probiotic supplementations significantly decreased the TNF-α circulating levels and significantly increased those of IGF-1. Biogenic-amine levels showed high variability, with significant variation only for histamine that decreased after the probiotic supplementation. The supplementation influenced the serum concentration of some crucial cytokines (IL-6, IL-8, and MIP-1α) that significantly decreased in the probiotic group. In addition, the Mini Nutritional Assessment questionnaire revealed that the probiotic-supplemented group had a significant improvement in nutritional status. In conclusion, the PROBIOSENIOR project demonstrated how SYNBIO<sup>®</sup> supplementation may positively influence some nutritional and inflammatory parameters in the elderly.https://www.mdpi.com/2076-2607/11/3/801probioticsmalnutritioninflammationelderly |
| spellingShingle | Chiara Salvesi Stefania Silvi Dennis Fiorini Laura Alessandroni Gianni Sagratini Francesco Alessandro Palermo Renato De Leone Nadaniela Egidi Carlo Cifani Maria Vittoria Micioni Di Bonaventura Amedeo Amedei Elena Niccolai Francesca Scocchera Fausto Mannucci Valerio Valeriani Marco Malavasi Sara Servili Andrea Casula Andrea Cresci Ivano Corradetti Maria Magdalena Coman M. Cristina Verdenelli Six-Month Synbio<sup>®</sup> Administration Affects Nutritional and Inflammatory Parameters of Older Adults Included in the PROBIOSENIOR Project Microorganisms probiotics malnutrition inflammation elderly |
| title | Six-Month Synbio<sup>®</sup> Administration Affects Nutritional and Inflammatory Parameters of Older Adults Included in the PROBIOSENIOR Project |
| title_full | Six-Month Synbio<sup>®</sup> Administration Affects Nutritional and Inflammatory Parameters of Older Adults Included in the PROBIOSENIOR Project |
| title_fullStr | Six-Month Synbio<sup>®</sup> Administration Affects Nutritional and Inflammatory Parameters of Older Adults Included in the PROBIOSENIOR Project |
| title_full_unstemmed | Six-Month Synbio<sup>®</sup> Administration Affects Nutritional and Inflammatory Parameters of Older Adults Included in the PROBIOSENIOR Project |
| title_short | Six-Month Synbio<sup>®</sup> Administration Affects Nutritional and Inflammatory Parameters of Older Adults Included in the PROBIOSENIOR Project |
| title_sort | six month synbio sup r sup administration affects nutritional and inflammatory parameters of older adults included in the probiosenior project |
| topic | probiotics malnutrition inflammation elderly |
| url | https://www.mdpi.com/2076-2607/11/3/801 |
| work_keys_str_mv | AT chiarasalvesi sixmonthsynbiosupsupadministrationaffectsnutritionalandinflammatoryparametersofolderadultsincludedintheprobioseniorproject AT stefaniasilvi sixmonthsynbiosupsupadministrationaffectsnutritionalandinflammatoryparametersofolderadultsincludedintheprobioseniorproject AT dennisfiorini sixmonthsynbiosupsupadministrationaffectsnutritionalandinflammatoryparametersofolderadultsincludedintheprobioseniorproject AT lauraalessandroni sixmonthsynbiosupsupadministrationaffectsnutritionalandinflammatoryparametersofolderadultsincludedintheprobioseniorproject AT giannisagratini sixmonthsynbiosupsupadministrationaffectsnutritionalandinflammatoryparametersofolderadultsincludedintheprobioseniorproject AT francescoalessandropalermo sixmonthsynbiosupsupadministrationaffectsnutritionalandinflammatoryparametersofolderadultsincludedintheprobioseniorproject AT renatodeleone sixmonthsynbiosupsupadministrationaffectsnutritionalandinflammatoryparametersofolderadultsincludedintheprobioseniorproject AT nadanielaegidi sixmonthsynbiosupsupadministrationaffectsnutritionalandinflammatoryparametersofolderadultsincludedintheprobioseniorproject AT carlocifani sixmonthsynbiosupsupadministrationaffectsnutritionalandinflammatoryparametersofolderadultsincludedintheprobioseniorproject AT mariavittoriamicionidibonaventura sixmonthsynbiosupsupadministrationaffectsnutritionalandinflammatoryparametersofolderadultsincludedintheprobioseniorproject AT amedeoamedei sixmonthsynbiosupsupadministrationaffectsnutritionalandinflammatoryparametersofolderadultsincludedintheprobioseniorproject AT elenaniccolai sixmonthsynbiosupsupadministrationaffectsnutritionalandinflammatoryparametersofolderadultsincludedintheprobioseniorproject AT francescascocchera sixmonthsynbiosupsupadministrationaffectsnutritionalandinflammatoryparametersofolderadultsincludedintheprobioseniorproject AT faustomannucci sixmonthsynbiosupsupadministrationaffectsnutritionalandinflammatoryparametersofolderadultsincludedintheprobioseniorproject AT valeriovaleriani sixmonthsynbiosupsupadministrationaffectsnutritionalandinflammatoryparametersofolderadultsincludedintheprobioseniorproject AT marcomalavasi sixmonthsynbiosupsupadministrationaffectsnutritionalandinflammatoryparametersofolderadultsincludedintheprobioseniorproject AT saraservili sixmonthsynbiosupsupadministrationaffectsnutritionalandinflammatoryparametersofolderadultsincludedintheprobioseniorproject AT andreacasula sixmonthsynbiosupsupadministrationaffectsnutritionalandinflammatoryparametersofolderadultsincludedintheprobioseniorproject AT andreacresci sixmonthsynbiosupsupadministrationaffectsnutritionalandinflammatoryparametersofolderadultsincludedintheprobioseniorproject AT ivanocorradetti sixmonthsynbiosupsupadministrationaffectsnutritionalandinflammatoryparametersofolderadultsincludedintheprobioseniorproject AT mariamagdalenacoman sixmonthsynbiosupsupadministrationaffectsnutritionalandinflammatoryparametersofolderadultsincludedintheprobioseniorproject AT mcristinaverdenelli sixmonthsynbiosupsupadministrationaffectsnutritionalandinflammatoryparametersofolderadultsincludedintheprobioseniorproject |