The role of optical coherence tomography angiography in distinguishing ischemic versus non-ischemic central retinal vein occlusion
Abstract Introduction: To observe macular microvascular changes in patients with ischemic and non-ischemic central retinal vein occlusion (CRVO) by optical coherence tomography angiography (OCTA), and explore the value of OCTA in differentiating ischemic and non-ischemic CRVO. Methods: Cross section...
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| Format: | Article |
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BMC
2022-10-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-022-02637-y |
| _version_ | 1797991646626840576 |
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| author | Weiting An Qi Zhao Rongguo Yu Jindong Han |
| author_facet | Weiting An Qi Zhao Rongguo Yu Jindong Han |
| author_sort | Weiting An |
| collection | DOAJ |
| description | Abstract Introduction: To observe macular microvascular changes in patients with ischemic and non-ischemic central retinal vein occlusion (CRVO) by optical coherence tomography angiography (OCTA), and explore the value of OCTA in differentiating ischemic and non-ischemic CRVO. Methods: Cross sectional study. Fifty patients diagnosed as CRVO with macular edema were included. Macular edema in all patients were regressive after three consecutive anti-VEGF treatment. Patients were divided into ischemic and non-ischemic group according to ultra-wide-angle fundus fluorescein angiography (UWFFA). All patients underwent BCVA, IOP, color fundus photography, UWFFA and OCTA. The following parameters were measured: (1) Vessel density (VD): superficial and deep whole VD (SVD, DVD), superficial and deep central fovea VD (SFVD, DFVD), superficial and deep parafoveal VD (SPFVD, DPFVD); (2) Central foveal retinal thickness (CRT); (3) Area of foveal avascular zone (FAZ), perimeter of FAZ (PERIM), avascular index of FAZ (AI) and VD within a width of 300 microns around the FAZ region (FD-300). Comparison between ischemic and non-ischemic group was performed by two independent sample t-tests. Receiver operating characteristic (ROC) curve analysis was used to measure the area under the curve (AUC) of VD for predicting ischemic CRVO. Results: There were no significant differences in IOP, SFVD, DFVD and CRT between ischemic and non-ischemic group, and significant differences in age, BCVA, SVD, SPFVD, DVD, DPFVD, FAZ area, PERIM, AI and FD-300 between ischemic and non-ischemic group. ROC curve analysis showed AUC of DVD and DPFVD in predicting ischemic CRVO was highest (0.962). the threshold was 38.40%, and the sensitivity was 100%, but the specificity of DVD (92.3%) was significantly higher than that of DPFVD (84.6%). Therefore, DVD ≤ 38.40% can be used as the best threshold for determining ischemic CRVO. Conclusion: OCTA can quantitatively evaluate the macular microvascular structure of CRVO, which is helpful to distinguish ischemic from non-ischemic CRVO. |
| first_indexed | 2024-04-11T08:55:23Z |
| format | Article |
| id | doaj.art-b67ff28974a7432184e7232dab42e00a |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-04-11T08:55:23Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
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| series | BMC Ophthalmology |
| spelling | doaj.art-b67ff28974a7432184e7232dab42e00a2022-12-22T04:33:19ZengBMCBMC Ophthalmology1471-24152022-10-012211610.1186/s12886-022-02637-yThe role of optical coherence tomography angiography in distinguishing ischemic versus non-ischemic central retinal vein occlusionWeiting An0Qi Zhao1Rongguo Yu2Jindong Han3Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute, School of Optometry, Tianjin Medical University Eye HospitalTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute, School of Optometry, Tianjin Medical University Eye HospitalTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute, School of Optometry, Tianjin Medical University Eye HospitalTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute, School of Optometry, Tianjin Medical University Eye HospitalAbstract Introduction: To observe macular microvascular changes in patients with ischemic and non-ischemic central retinal vein occlusion (CRVO) by optical coherence tomography angiography (OCTA), and explore the value of OCTA in differentiating ischemic and non-ischemic CRVO. Methods: Cross sectional study. Fifty patients diagnosed as CRVO with macular edema were included. Macular edema in all patients were regressive after three consecutive anti-VEGF treatment. Patients were divided into ischemic and non-ischemic group according to ultra-wide-angle fundus fluorescein angiography (UWFFA). All patients underwent BCVA, IOP, color fundus photography, UWFFA and OCTA. The following parameters were measured: (1) Vessel density (VD): superficial and deep whole VD (SVD, DVD), superficial and deep central fovea VD (SFVD, DFVD), superficial and deep parafoveal VD (SPFVD, DPFVD); (2) Central foveal retinal thickness (CRT); (3) Area of foveal avascular zone (FAZ), perimeter of FAZ (PERIM), avascular index of FAZ (AI) and VD within a width of 300 microns around the FAZ region (FD-300). Comparison between ischemic and non-ischemic group was performed by two independent sample t-tests. Receiver operating characteristic (ROC) curve analysis was used to measure the area under the curve (AUC) of VD for predicting ischemic CRVO. Results: There were no significant differences in IOP, SFVD, DFVD and CRT between ischemic and non-ischemic group, and significant differences in age, BCVA, SVD, SPFVD, DVD, DPFVD, FAZ area, PERIM, AI and FD-300 between ischemic and non-ischemic group. ROC curve analysis showed AUC of DVD and DPFVD in predicting ischemic CRVO was highest (0.962). the threshold was 38.40%, and the sensitivity was 100%, but the specificity of DVD (92.3%) was significantly higher than that of DPFVD (84.6%). Therefore, DVD ≤ 38.40% can be used as the best threshold for determining ischemic CRVO. Conclusion: OCTA can quantitatively evaluate the macular microvascular structure of CRVO, which is helpful to distinguish ischemic from non-ischemic CRVO.https://doi.org/10.1186/s12886-022-02637-yCentral retinal vein occlusionOptical coherence tomography angiographyIschemicNon-ischemic |
| spellingShingle | Weiting An Qi Zhao Rongguo Yu Jindong Han The role of optical coherence tomography angiography in distinguishing ischemic versus non-ischemic central retinal vein occlusion BMC Ophthalmology Central retinal vein occlusion Optical coherence tomography angiography Ischemic Non-ischemic |
| title | The role of optical coherence tomography angiography in distinguishing ischemic versus non-ischemic central retinal vein occlusion |
| title_full | The role of optical coherence tomography angiography in distinguishing ischemic versus non-ischemic central retinal vein occlusion |
| title_fullStr | The role of optical coherence tomography angiography in distinguishing ischemic versus non-ischemic central retinal vein occlusion |
| title_full_unstemmed | The role of optical coherence tomography angiography in distinguishing ischemic versus non-ischemic central retinal vein occlusion |
| title_short | The role of optical coherence tomography angiography in distinguishing ischemic versus non-ischemic central retinal vein occlusion |
| title_sort | role of optical coherence tomography angiography in distinguishing ischemic versus non ischemic central retinal vein occlusion |
| topic | Central retinal vein occlusion Optical coherence tomography angiography Ischemic Non-ischemic |
| url | https://doi.org/10.1186/s12886-022-02637-y |
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