Association between Hypocalcemia and Outcome in COVID-19 Patients: A Retrospective Study
Background Calcium has been shown to play a vital role in the pathophysiology of severe acute respiratory syndrome-coronavirus-2 and middle east respiratory syndrome coronavirus diseases, but less is known about hypocalcemia in coronavirus disease 2019 (COVID-19) patients and its association with th...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2023-06-01
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| Series: | Journal of Laboratory Physicians |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1757415 |
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| author | Bhagwan Singh Patidar Tapasyapreeti Mukhopadhyay Arulselvi Subramanian Richa Aggarwal Kapil Dev Soni Neeraj Nischal Debasis Sahoo Surbhi Surbhi Naveet Wig Ravindra Mohan Pandey Rajesh Malhotra Anjan Trikha |
| author_facet | Bhagwan Singh Patidar Tapasyapreeti Mukhopadhyay Arulselvi Subramanian Richa Aggarwal Kapil Dev Soni Neeraj Nischal Debasis Sahoo Surbhi Surbhi Naveet Wig Ravindra Mohan Pandey Rajesh Malhotra Anjan Trikha |
| author_sort | Bhagwan Singh Patidar |
| collection | DOAJ |
| description | Background Calcium has been shown to play a vital role in the pathophysiology of severe acute respiratory syndrome-coronavirus-2 and middle east respiratory syndrome coronavirus diseases, but less is known about hypocalcemia in coronavirus disease 2019 (COVID-19) patients and its association with the disease severity and the final outcome. Therefore, this study was conducted with an aim to assess clinical features in COVID-19 patients having hypocalcemia and to observe its impact on COVID-19 disease severity and the final outcome.
Methods In this retrospective study, consecutive COVID-19 patients of all age groups were enrolled. Demographical, clinical, and laboratory details were collected and analyzed. On the basis of albumin-corrected calcium levels, patients were classified into normocalcemic (n = 51) and hypocalcemic (n = 110) groups. Death was the primary outcome.
Results The mean age of patients in the hypocalcemic group was significantly lower (p < 0.05). A significantly higher number of hypocalcemic patients had severe COVID-19 infection (92.73%; p < 0.01), had comorbidities (82.73%, p < 0.05), and required ventilator support (39.09%; p < 0.01) compared with normocalcemic patients. The mortality rate was significantly higher in the hypocalcemic patients (33.63%; p < 0.05). Hemoglobin (p < 0.01), hematocrit (p < 0.01), and red cell count (p < 0.01) were significantly lower with higher levels of absolute neutrophil count (ANC; p < 0.05) and neutrophil-to-lymphocyte ratio (NLR; p < 0.01) in the hypocalcemic patients. Albumin-corrected calcium levels had a significant positive correlation with hemoglobin levels, hematocrit, red cell count, total protein, albumin, and albumin-to-globulin ratio and a significant negative correlation with ANC and NLR.
Conclusion The disease severity, ventilator requirement, and mortality were considerably higher in hypocalcemic COVID-19 patients. |
| first_indexed | 2024-03-13T05:43:01Z |
| format | Article |
| id | doaj.art-b6801078594544b98109198f8cf95c7f |
| institution | Directory Open Access Journal |
| issn | 0974-2727 0974-7826 |
| language | English |
| last_indexed | 2024-03-13T05:43:01Z |
| publishDate | 2023-06-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Journal of Laboratory Physicians |
| spelling | doaj.art-b6801078594544b98109198f8cf95c7f2023-06-13T23:22:37ZengThieme Medical and Scientific Publishers Pvt. Ltd.Journal of Laboratory Physicians0974-27270974-78262023-06-01150218719310.1055/s-0042-1757415Association between Hypocalcemia and Outcome in COVID-19 Patients: A Retrospective StudyBhagwan Singh Patidar0Tapasyapreeti Mukhopadhyay1Arulselvi Subramanian2Richa Aggarwal3Kapil Dev Soni4Neeraj Nischal5Debasis Sahoo6Surbhi Surbhi7Naveet Wig8Ravindra Mohan Pandey9Rajesh Malhotra10Anjan Trikha11Department of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Anaesthesia, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Anaesthesia, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Medicine, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Anaesthesia, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Anaesthesia, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Medicine, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Biostatistics, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Orthopedics, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences, New Delhi, IndiaBackground Calcium has been shown to play a vital role in the pathophysiology of severe acute respiratory syndrome-coronavirus-2 and middle east respiratory syndrome coronavirus diseases, but less is known about hypocalcemia in coronavirus disease 2019 (COVID-19) patients and its association with the disease severity and the final outcome. Therefore, this study was conducted with an aim to assess clinical features in COVID-19 patients having hypocalcemia and to observe its impact on COVID-19 disease severity and the final outcome. Methods In this retrospective study, consecutive COVID-19 patients of all age groups were enrolled. Demographical, clinical, and laboratory details were collected and analyzed. On the basis of albumin-corrected calcium levels, patients were classified into normocalcemic (n = 51) and hypocalcemic (n = 110) groups. Death was the primary outcome. Results The mean age of patients in the hypocalcemic group was significantly lower (p < 0.05). A significantly higher number of hypocalcemic patients had severe COVID-19 infection (92.73%; p < 0.01), had comorbidities (82.73%, p < 0.05), and required ventilator support (39.09%; p < 0.01) compared with normocalcemic patients. The mortality rate was significantly higher in the hypocalcemic patients (33.63%; p < 0.05). Hemoglobin (p < 0.01), hematocrit (p < 0.01), and red cell count (p < 0.01) were significantly lower with higher levels of absolute neutrophil count (ANC; p < 0.05) and neutrophil-to-lymphocyte ratio (NLR; p < 0.01) in the hypocalcemic patients. Albumin-corrected calcium levels had a significant positive correlation with hemoglobin levels, hematocrit, red cell count, total protein, albumin, and albumin-to-globulin ratio and a significant negative correlation with ANC and NLR. Conclusion The disease severity, ventilator requirement, and mortality were considerably higher in hypocalcemic COVID-19 patients.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1757415calciumcoronavirusmortalityneutrophil-to-lymphocyte ratiopandemic |
| spellingShingle | Bhagwan Singh Patidar Tapasyapreeti Mukhopadhyay Arulselvi Subramanian Richa Aggarwal Kapil Dev Soni Neeraj Nischal Debasis Sahoo Surbhi Surbhi Naveet Wig Ravindra Mohan Pandey Rajesh Malhotra Anjan Trikha Association between Hypocalcemia and Outcome in COVID-19 Patients: A Retrospective Study Journal of Laboratory Physicians calcium coronavirus mortality neutrophil-to-lymphocyte ratio pandemic |
| title | Association between Hypocalcemia and Outcome in COVID-19 Patients: A Retrospective Study |
| title_full | Association between Hypocalcemia and Outcome in COVID-19 Patients: A Retrospective Study |
| title_fullStr | Association between Hypocalcemia and Outcome in COVID-19 Patients: A Retrospective Study |
| title_full_unstemmed | Association between Hypocalcemia and Outcome in COVID-19 Patients: A Retrospective Study |
| title_short | Association between Hypocalcemia and Outcome in COVID-19 Patients: A Retrospective Study |
| title_sort | association between hypocalcemia and outcome in covid 19 patients a retrospective study |
| topic | calcium coronavirus mortality neutrophil-to-lymphocyte ratio pandemic |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1757415 |
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