Sorting nexin 17 increases low-density lipoprotein receptor-related protein 4 membrane expression: A novel mechanism of acetylcholine receptor aggregation in myasthenia gravis

Sorting nexin 17 increases low-density lipoprotein receptor-related protein 4 membrane expression: A novel mechanism of acetylcholine receptor aggregation in myasthenia gravis

Myasthenia gravis (MG) is characterized by autoimmune damage to the postsynaptic membrane of the neuromuscular junction (NMJ) with impaired postsynaptic acetylcholine receptor (AChR) aggregation. Low-density lipoprotein receptor-related protein 4 (LRP4) plays an important role in AChR aggregation at...

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Bibliographic Details
Main Authors: Xiaoxiao He, Shuxian Zhou, Ying Ji, Yingna Zhang, Jie Lv, Shangkun Quan, Jing Zhang, Xue Zhao, Weike Cui, Wenbo Li, Peipei Liu, Linyuan Zhang, Tong Shen, Hua Fang, Junhong Yang, Yunke Zhang, Xinzheng Cui, Qingyong Zhang, Feng Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
sorting nexin 17
low-density lipoprotein receptor-related protein 4
acetylcholine receptor
myasthenia gravis
endplate membranes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.916098/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.916098/full

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