Perturbations associated with hungry gut microbiome and postbiotic perspectives to strengthen the microbiome health
The imbalance in intestinal microbiota has serious consequences in human disease development such as inflammatory bowel, cardiovascular disorders, type II diabetes, obesity, cancer, respiratory disorders, and behavioral Alzheimer's and Parkinson's diseases. Therefore, the exploration of th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | Future Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666833521000332 |
| _version_ | 1818976473941278720 |
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| author | Simardeep Kaur Steffy Kaur Thukral Preetiman Kaur Mahesh Kumar Samota |
| author_facet | Simardeep Kaur Steffy Kaur Thukral Preetiman Kaur Mahesh Kumar Samota |
| author_sort | Simardeep Kaur |
| collection | DOAJ |
| description | The imbalance in intestinal microbiota has serious consequences in human disease development such as inflammatory bowel, cardiovascular disorders, type II diabetes, obesity, cancer, respiratory disorders, and behavioral Alzheimer's and Parkinson's diseases. Therefore, the exploration of therapeutic interventions for maintaining the healthy gut microbiome is essential. Although, prebiotics, probiotics, and synbiotics have been frequently used for modulating gut microbiome composition to healthier side. However, the presence of immunosuppressing organisms in probiotics imposes a risk (mainly associated with their intake). This provides the baseline for exploring another substitute group- ‘Postbiotics’. Postbiotics are non-viable metabolites, and the risks associated with their intake can be minimized as compared to probiotics. In this review, we discuss the development and perturbations associated with the gut microbiome, postbiotic classes, and pleiotropic effects, the efficacy of postbiotics in functional foods, and their potential future perspectives along with knowledge gaps. |
| first_indexed | 2024-12-20T16:12:25Z |
| format | Article |
| id | doaj.art-b680a3c0a9c540b1bc91ed9cc341968e |
| institution | Directory Open Access Journal |
| issn | 2666-8335 |
| language | English |
| last_indexed | 2024-12-20T16:12:25Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Future Foods |
| spelling | doaj.art-b680a3c0a9c540b1bc91ed9cc341968e2022-12-21T19:33:56ZengElsevierFuture Foods2666-83352021-12-014100043Perturbations associated with hungry gut microbiome and postbiotic perspectives to strengthen the microbiome healthSimardeep Kaur0Steffy Kaur Thukral1Preetiman Kaur2Mahesh Kumar Samota3Division of Biochemistry, ICAR-Indian Agricultural Research Institute, New Delhi- 110012, IndiaDepartment of Microbial Biotechnology, Panjab University, Chandigarh-160014, IndiaDepartment of Microbiology, Punjab Agricultural University, Ludhiana, Punjab- 141004, IndiaHCP Division, ICAR-CIPHET, Abohar, Punjab-152116, India; Corresponding author.The imbalance in intestinal microbiota has serious consequences in human disease development such as inflammatory bowel, cardiovascular disorders, type II diabetes, obesity, cancer, respiratory disorders, and behavioral Alzheimer's and Parkinson's diseases. Therefore, the exploration of therapeutic interventions for maintaining the healthy gut microbiome is essential. Although, prebiotics, probiotics, and synbiotics have been frequently used for modulating gut microbiome composition to healthier side. However, the presence of immunosuppressing organisms in probiotics imposes a risk (mainly associated with their intake). This provides the baseline for exploring another substitute group- ‘Postbiotics’. Postbiotics are non-viable metabolites, and the risks associated with their intake can be minimized as compared to probiotics. In this review, we discuss the development and perturbations associated with the gut microbiome, postbiotic classes, and pleiotropic effects, the efficacy of postbiotics in functional foods, and their potential future perspectives along with knowledge gaps.http://www.sciencedirect.com/science/article/pii/S2666833521000332Microbiomedysbiosispostbioticspleiotropic effects |
| spellingShingle | Simardeep Kaur Steffy Kaur Thukral Preetiman Kaur Mahesh Kumar Samota Perturbations associated with hungry gut microbiome and postbiotic perspectives to strengthen the microbiome health Future Foods Microbiome dysbiosis postbiotics pleiotropic effects |
| title | Perturbations associated with hungry gut microbiome and postbiotic perspectives to strengthen the microbiome health |
| title_full | Perturbations associated with hungry gut microbiome and postbiotic perspectives to strengthen the microbiome health |
| title_fullStr | Perturbations associated with hungry gut microbiome and postbiotic perspectives to strengthen the microbiome health |
| title_full_unstemmed | Perturbations associated with hungry gut microbiome and postbiotic perspectives to strengthen the microbiome health |
| title_short | Perturbations associated with hungry gut microbiome and postbiotic perspectives to strengthen the microbiome health |
| title_sort | perturbations associated with hungry gut microbiome and postbiotic perspectives to strengthen the microbiome health |
| topic | Microbiome dysbiosis postbiotics pleiotropic effects |
| url | http://www.sciencedirect.com/science/article/pii/S2666833521000332 |
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