Photomodulation Approaches to Overcome Antimicrobial Resistance
Photopharmacology is an approach that aims to be an alternative to classical chemotherapy. Herein, the different classes of photoswitches and photocleavage compounds and their biological applications are described. Proteolysis targeting chimeras (PROTACs) containing azobenzene moieties (PHOTACs) and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/16/5/682 |
| _version_ | 1797598723641966592 |
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| author | Sofia N. Sarabando Andreia Palmeira Maria Emília Sousa Maria Amparo F. Faustino Carlos J. P. Monteiro |
| author_facet | Sofia N. Sarabando Andreia Palmeira Maria Emília Sousa Maria Amparo F. Faustino Carlos J. P. Monteiro |
| author_sort | Sofia N. Sarabando |
| collection | DOAJ |
| description | Photopharmacology is an approach that aims to be an alternative to classical chemotherapy. Herein, the different classes of photoswitches and photocleavage compounds and their biological applications are described. Proteolysis targeting chimeras (PROTACs) containing azobenzene moieties (PHOTACs) and photocleavable protecting groups (photocaged PROTACs) are also mentioned. Furthermore, porphyrins are referenced as successful photoactive compounds in a clinical context, such as in the photodynamic therapy of tumours as well as preventing antimicrobial resistance, namely in bacteria. Porphyrins combining photoswitches and photocleavage systems are highlighted, taking advantage of both photopharmacology and photodynamic action. Finally, porphyrins with antibacterial activity are described, taking advantage of the synergistic effect of photodynamic treatment and antibiotic therapy to overcome bacterial resistance. |
| first_indexed | 2024-03-11T03:25:45Z |
| format | Article |
| id | doaj.art-b680e1483d9940b29c908b15103c5b11 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-11T03:25:45Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-b680e1483d9940b29c908b15103c5b112023-11-18T02:48:26ZengMDPI AGPharmaceuticals1424-82472023-05-0116568210.3390/ph16050682Photomodulation Approaches to Overcome Antimicrobial ResistanceSofia N. Sarabando0Andreia Palmeira1Maria Emília Sousa2Maria Amparo F. Faustino3Carlos J. P. Monteiro4Laboratory of Organic and Pharmaceutical Chemistry, Chemical Sciences Department, Faculty of Pharmacy, University of Porto, 4050-313 Porto, PortugalLaboratory of Organic and Pharmaceutical Chemistry, Chemical Sciences Department, Faculty of Pharmacy, University of Porto, 4050-313 Porto, PortugalLaboratory of Organic and Pharmaceutical Chemistry, Chemical Sciences Department, Faculty of Pharmacy, University of Porto, 4050-313 Porto, PortugalLAQV-Requimte and Department of Chemistry, University of Aveiro, 3010-193 Aveiro, PortugalLAQV-Requimte and Department of Chemistry, University of Aveiro, 3010-193 Aveiro, PortugalPhotopharmacology is an approach that aims to be an alternative to classical chemotherapy. Herein, the different classes of photoswitches and photocleavage compounds and their biological applications are described. Proteolysis targeting chimeras (PROTACs) containing azobenzene moieties (PHOTACs) and photocleavable protecting groups (photocaged PROTACs) are also mentioned. Furthermore, porphyrins are referenced as successful photoactive compounds in a clinical context, such as in the photodynamic therapy of tumours as well as preventing antimicrobial resistance, namely in bacteria. Porphyrins combining photoswitches and photocleavage systems are highlighted, taking advantage of both photopharmacology and photodynamic action. Finally, porphyrins with antibacterial activity are described, taking advantage of the synergistic effect of photodynamic treatment and antibiotic therapy to overcome bacterial resistance.https://www.mdpi.com/1424-8247/16/5/682photopharmacologyphotoswitchphotocagedporphyrinantimicrobials |
| spellingShingle | Sofia N. Sarabando Andreia Palmeira Maria Emília Sousa Maria Amparo F. Faustino Carlos J. P. Monteiro Photomodulation Approaches to Overcome Antimicrobial Resistance Pharmaceuticals photopharmacology photoswitch photocaged porphyrin antimicrobials |
| title | Photomodulation Approaches to Overcome Antimicrobial Resistance |
| title_full | Photomodulation Approaches to Overcome Antimicrobial Resistance |
| title_fullStr | Photomodulation Approaches to Overcome Antimicrobial Resistance |
| title_full_unstemmed | Photomodulation Approaches to Overcome Antimicrobial Resistance |
| title_short | Photomodulation Approaches to Overcome Antimicrobial Resistance |
| title_sort | photomodulation approaches to overcome antimicrobial resistance |
| topic | photopharmacology photoswitch photocaged porphyrin antimicrobials |
| url | https://www.mdpi.com/1424-8247/16/5/682 |
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