Modified Curcumins as Potential Drug Candidates for Breast Cancer: An Overview
Breast cancer (BC), the most common malignancy in women, results from significant alterations in genetic and epigenetic mechanisms that alter multiple signaling pathways in growth and malignant progression, leading to limited long-term survival. Current studies with numerous drug therapies have show...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/24/8891 |
| _version_ | 1797456030586634240 |
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| author | Abigail L. Flint David W. Hansen LaVauria D. Brown Laura E. Stewart Eduardo Ortiz Siva S. Panda |
| author_facet | Abigail L. Flint David W. Hansen LaVauria D. Brown Laura E. Stewart Eduardo Ortiz Siva S. Panda |
| author_sort | Abigail L. Flint |
| collection | DOAJ |
| description | Breast cancer (BC), the most common malignancy in women, results from significant alterations in genetic and epigenetic mechanisms that alter multiple signaling pathways in growth and malignant progression, leading to limited long-term survival. Current studies with numerous drug therapies have shown that BC is a complex disease with tumor heterogeneity, rapidity, and dynamics of the tumor microenvironment that result in resistance to existing therapy. Targeting a single cell-signaling pathway is unlikely to treat or prevent BC. Curcumin (a natural yellow pigment), the principal ingredient in the spice turmeric, is well-documented for its diverse pharmacological properties including anti-cancer activity. However, its clinical application has been limited because of its low solubility, stability, and bioavailability. To overcome the limitation of curcumin, several modified curcumin conjugates and curcumin mimics were developed and studied for their anti-cancer properties. In this review, we have focused on the application of curcumin mimics and their conjugates for breast cancer. |
| first_indexed | 2024-03-09T16:02:33Z |
| format | Article |
| id | doaj.art-b680e35faffe4f87b756542a480999e8 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T16:02:33Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-b680e35faffe4f87b756542a480999e82023-11-24T16:59:11ZengMDPI AGMolecules1420-30492022-12-012724889110.3390/molecules27248891Modified Curcumins as Potential Drug Candidates for Breast Cancer: An OverviewAbigail L. Flint0David W. Hansen1LaVauria D. Brown2Laura E. Stewart3Eduardo Ortiz4Siva S. Panda5Department of Chemistry & Physics, Augusta University, Augusta, GA 30912, USADepartment of Chemistry & Physics, Augusta University, Augusta, GA 30912, USADepartment of Chemistry & Physics, Augusta University, Augusta, GA 30912, USADepartment of Chemistry & Physics, Augusta University, Augusta, GA 30912, USADepartment of Chemistry & Physics, Augusta University, Augusta, GA 30912, USADepartment of Chemistry & Physics, Augusta University, Augusta, GA 30912, USABreast cancer (BC), the most common malignancy in women, results from significant alterations in genetic and epigenetic mechanisms that alter multiple signaling pathways in growth and malignant progression, leading to limited long-term survival. Current studies with numerous drug therapies have shown that BC is a complex disease with tumor heterogeneity, rapidity, and dynamics of the tumor microenvironment that result in resistance to existing therapy. Targeting a single cell-signaling pathway is unlikely to treat or prevent BC. Curcumin (a natural yellow pigment), the principal ingredient in the spice turmeric, is well-documented for its diverse pharmacological properties including anti-cancer activity. However, its clinical application has been limited because of its low solubility, stability, and bioavailability. To overcome the limitation of curcumin, several modified curcumin conjugates and curcumin mimics were developed and studied for their anti-cancer properties. In this review, we have focused on the application of curcumin mimics and their conjugates for breast cancer.https://www.mdpi.com/1420-3049/27/24/8891curcumincurcumin mimicconjugatesbreast cancersynthesisdrug development |
| spellingShingle | Abigail L. Flint David W. Hansen LaVauria D. Brown Laura E. Stewart Eduardo Ortiz Siva S. Panda Modified Curcumins as Potential Drug Candidates for Breast Cancer: An Overview Molecules curcumin curcumin mimic conjugates breast cancer synthesis drug development |
| title | Modified Curcumins as Potential Drug Candidates for Breast Cancer: An Overview |
| title_full | Modified Curcumins as Potential Drug Candidates for Breast Cancer: An Overview |
| title_fullStr | Modified Curcumins as Potential Drug Candidates for Breast Cancer: An Overview |
| title_full_unstemmed | Modified Curcumins as Potential Drug Candidates for Breast Cancer: An Overview |
| title_short | Modified Curcumins as Potential Drug Candidates for Breast Cancer: An Overview |
| title_sort | modified curcumins as potential drug candidates for breast cancer an overview |
| topic | curcumin curcumin mimic conjugates breast cancer synthesis drug development |
| url | https://www.mdpi.com/1420-3049/27/24/8891 |
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