Modification of Collagen/Gelatin/Hydroxyethyl Cellulose-Based Materials by Addition of Herbal Extract-Loaded Microspheres Made from Gellan Gum and Xanthan Gum
Because consumers are nowadays focused on their health and appearance, natural ingredients and their novel delivery systems are one of the most developing fields of pharmacy, medicine, and cosmetics. The main goal of this study was to design, prepare, and characterize composite materials obtained by...
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| Format: | Article |
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MDPI AG
2020-08-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/13/16/3507 |
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| author | Justyna Kozlowska Weronika Prus-Walendziak Natalia Stachowiak Anna Bajek Lukasz Kazmierski Bartosz Tylkowski |
| author_facet | Justyna Kozlowska Weronika Prus-Walendziak Natalia Stachowiak Anna Bajek Lukasz Kazmierski Bartosz Tylkowski |
| author_sort | Justyna Kozlowska |
| collection | DOAJ |
| description | Because consumers are nowadays focused on their health and appearance, natural ingredients and their novel delivery systems are one of the most developing fields of pharmacy, medicine, and cosmetics. The main goal of this study was to design, prepare, and characterize composite materials obtained by incorporation of microspheres into the porous polymer materials consisting of collagen, gelatin, and hydroxyethyl cellulose. Microspheres, based on gellan gum and xanthan gum with encapsulated <i>Calendula officinalis</i> flower extract, were produced by two methods: extrusion and emulsification. The release profile of the extract from both types of microspheres was compared. Then, obtained microparticles were incorporated into polymeric materials with a porous structure. This modification had an influence on porosity, density, swelling properties, mechanical properties, and stability of materials. Besides, in vitro tests were performed using mouse fibroblasts. Cell viability was assessed with the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The obtained materials, especially with microspheres prepared by emulsion method, can be potentially helpful when designing cosmetic forms because they were made from safely for skin ingredients used in this industry and the herbal extract was successfully encapsulated into microparticles. |
| first_indexed | 2024-03-10T17:45:14Z |
| format | Article |
| id | doaj.art-b680ee1f97b043d58a8f2cf6532b2125 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T17:45:14Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-b680ee1f97b043d58a8f2cf6532b21252023-11-20T09:33:40ZengMDPI AGMaterials1996-19442020-08-011316350710.3390/ma13163507Modification of Collagen/Gelatin/Hydroxyethyl Cellulose-Based Materials by Addition of Herbal Extract-Loaded Microspheres Made from Gellan Gum and Xanthan GumJustyna Kozlowska0Weronika Prus-Walendziak1Natalia Stachowiak2Anna Bajek3Lukasz Kazmierski4Bartosz Tylkowski5Faculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, 87-100 Torun, PolandFaculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, 87-100 Torun, PolandFaculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, 87-100 Torun, PolandThe Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Karlowicza 24, 85-092 Bydgoszcz, PolandThe Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Karlowicza 24, 85-092 Bydgoszcz, PolandEurecat, Centre Tecnològic de Catalunya, C/Marcellí Domingo, 43007 Tarragona, SpainBecause consumers are nowadays focused on their health and appearance, natural ingredients and their novel delivery systems are one of the most developing fields of pharmacy, medicine, and cosmetics. The main goal of this study was to design, prepare, and characterize composite materials obtained by incorporation of microspheres into the porous polymer materials consisting of collagen, gelatin, and hydroxyethyl cellulose. Microspheres, based on gellan gum and xanthan gum with encapsulated <i>Calendula officinalis</i> flower extract, were produced by two methods: extrusion and emulsification. The release profile of the extract from both types of microspheres was compared. Then, obtained microparticles were incorporated into polymeric materials with a porous structure. This modification had an influence on porosity, density, swelling properties, mechanical properties, and stability of materials. Besides, in vitro tests were performed using mouse fibroblasts. Cell viability was assessed with the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The obtained materials, especially with microspheres prepared by emulsion method, can be potentially helpful when designing cosmetic forms because they were made from safely for skin ingredients used in this industry and the herbal extract was successfully encapsulated into microparticles.https://www.mdpi.com/1996-1944/13/16/3507encapsulationmicrospheres<i>Calendula officinalis</i> flower extractrelease profilestructurestability |
| spellingShingle | Justyna Kozlowska Weronika Prus-Walendziak Natalia Stachowiak Anna Bajek Lukasz Kazmierski Bartosz Tylkowski Modification of Collagen/Gelatin/Hydroxyethyl Cellulose-Based Materials by Addition of Herbal Extract-Loaded Microspheres Made from Gellan Gum and Xanthan Gum Materials encapsulation microspheres <i>Calendula officinalis</i> flower extract release profile structure stability |
| title | Modification of Collagen/Gelatin/Hydroxyethyl Cellulose-Based Materials by Addition of Herbal Extract-Loaded Microspheres Made from Gellan Gum and Xanthan Gum |
| title_full | Modification of Collagen/Gelatin/Hydroxyethyl Cellulose-Based Materials by Addition of Herbal Extract-Loaded Microspheres Made from Gellan Gum and Xanthan Gum |
| title_fullStr | Modification of Collagen/Gelatin/Hydroxyethyl Cellulose-Based Materials by Addition of Herbal Extract-Loaded Microspheres Made from Gellan Gum and Xanthan Gum |
| title_full_unstemmed | Modification of Collagen/Gelatin/Hydroxyethyl Cellulose-Based Materials by Addition of Herbal Extract-Loaded Microspheres Made from Gellan Gum and Xanthan Gum |
| title_short | Modification of Collagen/Gelatin/Hydroxyethyl Cellulose-Based Materials by Addition of Herbal Extract-Loaded Microspheres Made from Gellan Gum and Xanthan Gum |
| title_sort | modification of collagen gelatin hydroxyethyl cellulose based materials by addition of herbal extract loaded microspheres made from gellan gum and xanthan gum |
| topic | encapsulation microspheres <i>Calendula officinalis</i> flower extract release profile structure stability |
| url | https://www.mdpi.com/1996-1944/13/16/3507 |
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