Evaluation of Duration of Immunogenicity and Protective Efficacy of Improved Influenza Viral Vector–Based Brucella abortus Vaccine Against Brucella melitensis Infection in Sheep and Goats

Evaluation of Duration of Immunogenicity and Protective Efficacy of Improved Influenza Viral Vector–Based Brucella abortus Vaccine Against Brucella melitensis Infection in Sheep and Goats

In this study, we first evaluated the duration of a protective immune response against Brucella melitensis infection in non-pregnant sheep and goats immunized with an improved (by vaccine formulation and route of administration) commercial Brucella abortus vaccine based on influenza viral vectors ex...

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Bibliographic Details
Main Authors: Aigerim Mailybayeva, Sholpan Ryskeldinova, Nadezhda Zinina, En-Min Zhou, Gourapura J. Renukaradhya, Kaissar Tabynov
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Veterinary Science
Subjects:
Brucella melitensis
influenza viral vector
vaccine
T-cell–mediated immune response
prolonged efficacy
small ruminants
Online Access:https://www.frontiersin.org/article/10.3389/fvets.2020.00058/full

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