Angiotensin-converting enzyme (ACE) inhibitory activity of Solanum torvum and isolation of a novel methyl salicylate glycoside
A methanolic extract from Solanum torvum fruits exhibited inhibitory activity against the angiotensin-converting enzyme (ACE) with an IC50 value of 1.2 mg/mL. On the basis of a bioassay-guided isolation, an ACE inhibitory active compound, namely (E)-2,3-dihydroxycyclopentyl-3-(3′,4′-dihydroxyphenyl)...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-11-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464614002734 |
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| author | Arunee Simaratanamongkol Kaoru Umehara Hiroki Niki Hiroshi Noguchi Pharkphoom Panichayupakaranant |
| author_facet | Arunee Simaratanamongkol Kaoru Umehara Hiroki Niki Hiroshi Noguchi Pharkphoom Panichayupakaranant |
| author_sort | Arunee Simaratanamongkol |
| collection | DOAJ |
| description | A methanolic extract from Solanum torvum fruits exhibited inhibitory activity against the angiotensin-converting enzyme (ACE) with an IC50 value of 1.2 mg/mL. On the basis of a bioassay-guided isolation, an ACE inhibitory active compound, namely (E)-2,3-dihydroxycyclopentyl-3-(3′,4′-dihydroxyphenyl)acrylate (1) (IC50 of 778 µg/mL), was obtained, together with a novel methyl salicylate glycoside – torvumoside [methyl salicylate 2-O-(2′-O-β-apiofuranosyl, 6′-O-β-xylopyranosyl)-β-glucopyranoside] (3) and a known compound, lariciresinol-4,4′-O-β-D-diglucoside (2). This is the first report of these compounds in this plant. |
| first_indexed | 2024-12-20T05:45:50Z |
| format | Article |
| id | doaj.art-b682dcc219914d7f9330966e16daefaa |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T05:45:50Z |
| publishDate | 2014-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-b682dcc219914d7f9330966e16daefaa2022-12-21T19:51:20ZengElsevierJournal of Functional Foods1756-46462014-11-0111557562Angiotensin-converting enzyme (ACE) inhibitory activity of Solanum torvum and isolation of a novel methyl salicylate glycosideArunee Simaratanamongkol0Kaoru Umehara1Hiroki Niki2Hiroshi Noguchi3Pharkphoom Panichayupakaranant4Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, ThailandSchool of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, JapanSchool of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, JapanPhytomedicine and Pharmaceutical Biotechnology Excellence Center, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, ThailandDepartment of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand; Phytomedicine and Pharmaceutical Biotechnology Excellence Center, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand; Corresponding author. Tel.: +66 74 428220; fax: +66 74 428220.A methanolic extract from Solanum torvum fruits exhibited inhibitory activity against the angiotensin-converting enzyme (ACE) with an IC50 value of 1.2 mg/mL. On the basis of a bioassay-guided isolation, an ACE inhibitory active compound, namely (E)-2,3-dihydroxycyclopentyl-3-(3′,4′-dihydroxyphenyl)acrylate (1) (IC50 of 778 µg/mL), was obtained, together with a novel methyl salicylate glycoside – torvumoside [methyl salicylate 2-O-(2′-O-β-apiofuranosyl, 6′-O-β-xylopyranosyl)-β-glucopyranoside] (3) and a known compound, lariciresinol-4,4′-O-β-D-diglucoside (2). This is the first report of these compounds in this plant.http://www.sciencedirect.com/science/article/pii/S1756464614002734Solanum torvumAngiotensin converting enzymeACEMethyl salicylate glycosideTorvumoside(E)-2,3-Dihydroxycyclopentyl-3-(3′,4′-dihydroxyphenyl) acrylate |
| spellingShingle | Arunee Simaratanamongkol Kaoru Umehara Hiroki Niki Hiroshi Noguchi Pharkphoom Panichayupakaranant Angiotensin-converting enzyme (ACE) inhibitory activity of Solanum torvum and isolation of a novel methyl salicylate glycoside Journal of Functional Foods Solanum torvum Angiotensin converting enzyme ACE Methyl salicylate glycoside Torvumoside (E)-2,3-Dihydroxycyclopentyl-3-(3′,4′-dihydroxyphenyl) acrylate |
| title | Angiotensin-converting enzyme (ACE) inhibitory activity of Solanum torvum and isolation of a novel methyl salicylate glycoside |
| title_full | Angiotensin-converting enzyme (ACE) inhibitory activity of Solanum torvum and isolation of a novel methyl salicylate glycoside |
| title_fullStr | Angiotensin-converting enzyme (ACE) inhibitory activity of Solanum torvum and isolation of a novel methyl salicylate glycoside |
| title_full_unstemmed | Angiotensin-converting enzyme (ACE) inhibitory activity of Solanum torvum and isolation of a novel methyl salicylate glycoside |
| title_short | Angiotensin-converting enzyme (ACE) inhibitory activity of Solanum torvum and isolation of a novel methyl salicylate glycoside |
| title_sort | angiotensin converting enzyme ace inhibitory activity of solanum torvum and isolation of a novel methyl salicylate glycoside |
| topic | Solanum torvum Angiotensin converting enzyme ACE Methyl salicylate glycoside Torvumoside (E)-2,3-Dihydroxycyclopentyl-3-(3′,4′-dihydroxyphenyl) acrylate |
| url | http://www.sciencedirect.com/science/article/pii/S1756464614002734 |
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