Obesity and risk of fracture in postmenopausal women: a meta-analysis of cohort studies

AbstractBackground Obesity is associated with an increased risk of fracture in adults, but is unclear in postmenopausal women. We aim to determine the association of obesity with the risk of fracture in postmenopausal women.Methods PubMed, EMBASE, Cochrane Library and Web of Science were searched up...

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Main Authors: Hong-fei Liu, Dong-fang Meng, Peng Yu, Ji-cao De, Hui-ying Li
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Annals of Medicine
Subjects:
Online Access:https://www.tandfonline.com/doi/10.1080/07853890.2023.2203515
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author Hong-fei Liu
Dong-fang Meng
Peng Yu
Ji-cao De
Hui-ying Li
author_facet Hong-fei Liu
Dong-fang Meng
Peng Yu
Ji-cao De
Hui-ying Li
author_sort Hong-fei Liu
collection DOAJ
description AbstractBackground Obesity is associated with an increased risk of fracture in adults, but is unclear in postmenopausal women. We aim to determine the association of obesity with the risk of fracture in postmenopausal women.Methods PubMed, EMBASE, Cochrane Library and Web of Science were searched up to 11 April 2022 for cohort studies. And the included studies regarding the relationship between obesity with all cause of fracture in postmenopausal women were included in our meta-analysis. Data were screened and extracted independently by two reviewers. The relative risks (RR) were estimated using a random-effects model. Between-study heterogeneity was assessed using Cochran’s Q and I2 statistics.Results Eight cohort studies comprising 671,532 postmenopausal women and 40,172 fractures were included. Overall, the pooling analysis shows that obesity in postmenopausal women is associated with an increased risk of all-cause fracture (relative ratio (RR) = 1.18; 95% confidence interval (CI):1.09–1.28, I2 = 86.3%, p = .000). Sub-analyses for each site of fracture indicate that obesity was associated with an increased risk of vertebral fracture in postmenopausal women (RR = 1.154, 95% CI: 1.020–1.305, I2 = 94.5%, p = .023), but reduced the risk of pelvic fracture (RR = 0.575, 95% CI:0.470–0.702, I2 = 0.0%, p = .000). There is no statistically significant difference in the risk of hip and humerus fractures associated with obesity in postmenopausal women.Conclusion Obesity is associated with an increased risk of all-cause and vertebral fractures in postmenopausal women, but is a protective factor for pelvic fractures. Our findings suggest that postmenopausal women who regulate their weight might lower their risk of fractures.Registration: (PROSPERO: CRD42022324973)KEY MESSAGESObesity is associated with an increased risk of all-cause and vertebral fractures in postmenopausal women.Obesity maybe a protective factor for pelvic fractures in postmenopausal women.Postmenopausal women should regulate their weight to prevent fractures.
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spelling doaj.art-b68419c351c04fec830386c9ff691b432024-01-16T19:13:22ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602023-12-0155110.1080/07853890.2023.2203515Obesity and risk of fracture in postmenopausal women: a meta-analysis of cohort studiesHong-fei Liu0Dong-fang Meng1Peng Yu2Ji-cao De3Hui-ying Li4College of Orthopaedics and Traumatology, Henan University of Chinese Medicine, Zhengzhou, Henan, ChinaOrthopaedic Department, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, ChinaCollege of Orthopaedics and Traumatology, Henan University of Chinese Medicine, Zhengzhou, Henan, ChinaClinical Medicine, Gannan Tibetan Autonomous Prefecture Tibetan Medical Hospital, Gannan, Gansu, ChinaOrthopaedic Department, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, ChinaAbstractBackground Obesity is associated with an increased risk of fracture in adults, but is unclear in postmenopausal women. We aim to determine the association of obesity with the risk of fracture in postmenopausal women.Methods PubMed, EMBASE, Cochrane Library and Web of Science were searched up to 11 April 2022 for cohort studies. And the included studies regarding the relationship between obesity with all cause of fracture in postmenopausal women were included in our meta-analysis. Data were screened and extracted independently by two reviewers. The relative risks (RR) were estimated using a random-effects model. Between-study heterogeneity was assessed using Cochran’s Q and I2 statistics.Results Eight cohort studies comprising 671,532 postmenopausal women and 40,172 fractures were included. Overall, the pooling analysis shows that obesity in postmenopausal women is associated with an increased risk of all-cause fracture (relative ratio (RR) = 1.18; 95% confidence interval (CI):1.09–1.28, I2 = 86.3%, p = .000). Sub-analyses for each site of fracture indicate that obesity was associated with an increased risk of vertebral fracture in postmenopausal women (RR = 1.154, 95% CI: 1.020–1.305, I2 = 94.5%, p = .023), but reduced the risk of pelvic fracture (RR = 0.575, 95% CI:0.470–0.702, I2 = 0.0%, p = .000). There is no statistically significant difference in the risk of hip and humerus fractures associated with obesity in postmenopausal women.Conclusion Obesity is associated with an increased risk of all-cause and vertebral fractures in postmenopausal women, but is a protective factor for pelvic fractures. Our findings suggest that postmenopausal women who regulate their weight might lower their risk of fractures.Registration: (PROSPERO: CRD42022324973)KEY MESSAGESObesity is associated with an increased risk of all-cause and vertebral fractures in postmenopausal women.Obesity maybe a protective factor for pelvic fractures in postmenopausal women.Postmenopausal women should regulate their weight to prevent fractures.https://www.tandfonline.com/doi/10.1080/07853890.2023.2203515Obesityfracturepostmenopausal womenmeta-analysiscohort study
spellingShingle Hong-fei Liu
Dong-fang Meng
Peng Yu
Ji-cao De
Hui-ying Li
Obesity and risk of fracture in postmenopausal women: a meta-analysis of cohort studies
Annals of Medicine
Obesity
fracture
postmenopausal women
meta-analysis
cohort study
title Obesity and risk of fracture in postmenopausal women: a meta-analysis of cohort studies
title_full Obesity and risk of fracture in postmenopausal women: a meta-analysis of cohort studies
title_fullStr Obesity and risk of fracture in postmenopausal women: a meta-analysis of cohort studies
title_full_unstemmed Obesity and risk of fracture in postmenopausal women: a meta-analysis of cohort studies
title_short Obesity and risk of fracture in postmenopausal women: a meta-analysis of cohort studies
title_sort obesity and risk of fracture in postmenopausal women a meta analysis of cohort studies
topic Obesity
fracture
postmenopausal women
meta-analysis
cohort study
url https://www.tandfonline.com/doi/10.1080/07853890.2023.2203515
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