Obesity and risk of fracture in postmenopausal women: a meta-analysis of cohort studies
AbstractBackground Obesity is associated with an increased risk of fracture in adults, but is unclear in postmenopausal women. We aim to determine the association of obesity with the risk of fracture in postmenopausal women.Methods PubMed, EMBASE, Cochrane Library and Web of Science were searched up...
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Taylor & Francis Group
2023-12-01
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Series: | Annals of Medicine |
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Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2023.2203515 |
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author | Hong-fei Liu Dong-fang Meng Peng Yu Ji-cao De Hui-ying Li |
author_facet | Hong-fei Liu Dong-fang Meng Peng Yu Ji-cao De Hui-ying Li |
author_sort | Hong-fei Liu |
collection | DOAJ |
description | AbstractBackground Obesity is associated with an increased risk of fracture in adults, but is unclear in postmenopausal women. We aim to determine the association of obesity with the risk of fracture in postmenopausal women.Methods PubMed, EMBASE, Cochrane Library and Web of Science were searched up to 11 April 2022 for cohort studies. And the included studies regarding the relationship between obesity with all cause of fracture in postmenopausal women were included in our meta-analysis. Data were screened and extracted independently by two reviewers. The relative risks (RR) were estimated using a random-effects model. Between-study heterogeneity was assessed using Cochran’s Q and I2 statistics.Results Eight cohort studies comprising 671,532 postmenopausal women and 40,172 fractures were included. Overall, the pooling analysis shows that obesity in postmenopausal women is associated with an increased risk of all-cause fracture (relative ratio (RR) = 1.18; 95% confidence interval (CI):1.09–1.28, I2 = 86.3%, p = .000). Sub-analyses for each site of fracture indicate that obesity was associated with an increased risk of vertebral fracture in postmenopausal women (RR = 1.154, 95% CI: 1.020–1.305, I2 = 94.5%, p = .023), but reduced the risk of pelvic fracture (RR = 0.575, 95% CI:0.470–0.702, I2 = 0.0%, p = .000). There is no statistically significant difference in the risk of hip and humerus fractures associated with obesity in postmenopausal women.Conclusion Obesity is associated with an increased risk of all-cause and vertebral fractures in postmenopausal women, but is a protective factor for pelvic fractures. Our findings suggest that postmenopausal women who regulate their weight might lower their risk of fractures.Registration: (PROSPERO: CRD42022324973)KEY MESSAGESObesity is associated with an increased risk of all-cause and vertebral fractures in postmenopausal women.Obesity maybe a protective factor for pelvic fractures in postmenopausal women.Postmenopausal women should regulate their weight to prevent fractures. |
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issn | 0785-3890 1365-2060 |
language | English |
last_indexed | 2024-03-08T13:34:37Z |
publishDate | 2023-12-01 |
publisher | Taylor & Francis Group |
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series | Annals of Medicine |
spelling | doaj.art-b68419c351c04fec830386c9ff691b432024-01-16T19:13:22ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602023-12-0155110.1080/07853890.2023.2203515Obesity and risk of fracture in postmenopausal women: a meta-analysis of cohort studiesHong-fei Liu0Dong-fang Meng1Peng Yu2Ji-cao De3Hui-ying Li4College of Orthopaedics and Traumatology, Henan University of Chinese Medicine, Zhengzhou, Henan, ChinaOrthopaedic Department, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, ChinaCollege of Orthopaedics and Traumatology, Henan University of Chinese Medicine, Zhengzhou, Henan, ChinaClinical Medicine, Gannan Tibetan Autonomous Prefecture Tibetan Medical Hospital, Gannan, Gansu, ChinaOrthopaedic Department, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, ChinaAbstractBackground Obesity is associated with an increased risk of fracture in adults, but is unclear in postmenopausal women. We aim to determine the association of obesity with the risk of fracture in postmenopausal women.Methods PubMed, EMBASE, Cochrane Library and Web of Science were searched up to 11 April 2022 for cohort studies. And the included studies regarding the relationship between obesity with all cause of fracture in postmenopausal women were included in our meta-analysis. Data were screened and extracted independently by two reviewers. The relative risks (RR) were estimated using a random-effects model. Between-study heterogeneity was assessed using Cochran’s Q and I2 statistics.Results Eight cohort studies comprising 671,532 postmenopausal women and 40,172 fractures were included. Overall, the pooling analysis shows that obesity in postmenopausal women is associated with an increased risk of all-cause fracture (relative ratio (RR) = 1.18; 95% confidence interval (CI):1.09–1.28, I2 = 86.3%, p = .000). Sub-analyses for each site of fracture indicate that obesity was associated with an increased risk of vertebral fracture in postmenopausal women (RR = 1.154, 95% CI: 1.020–1.305, I2 = 94.5%, p = .023), but reduced the risk of pelvic fracture (RR = 0.575, 95% CI:0.470–0.702, I2 = 0.0%, p = .000). There is no statistically significant difference in the risk of hip and humerus fractures associated with obesity in postmenopausal women.Conclusion Obesity is associated with an increased risk of all-cause and vertebral fractures in postmenopausal women, but is a protective factor for pelvic fractures. Our findings suggest that postmenopausal women who regulate their weight might lower their risk of fractures.Registration: (PROSPERO: CRD42022324973)KEY MESSAGESObesity is associated with an increased risk of all-cause and vertebral fractures in postmenopausal women.Obesity maybe a protective factor for pelvic fractures in postmenopausal women.Postmenopausal women should regulate their weight to prevent fractures.https://www.tandfonline.com/doi/10.1080/07853890.2023.2203515Obesityfracturepostmenopausal womenmeta-analysiscohort study |
spellingShingle | Hong-fei Liu Dong-fang Meng Peng Yu Ji-cao De Hui-ying Li Obesity and risk of fracture in postmenopausal women: a meta-analysis of cohort studies Annals of Medicine Obesity fracture postmenopausal women meta-analysis cohort study |
title | Obesity and risk of fracture in postmenopausal women: a meta-analysis of cohort studies |
title_full | Obesity and risk of fracture in postmenopausal women: a meta-analysis of cohort studies |
title_fullStr | Obesity and risk of fracture in postmenopausal women: a meta-analysis of cohort studies |
title_full_unstemmed | Obesity and risk of fracture in postmenopausal women: a meta-analysis of cohort studies |
title_short | Obesity and risk of fracture in postmenopausal women: a meta-analysis of cohort studies |
title_sort | obesity and risk of fracture in postmenopausal women a meta analysis of cohort studies |
topic | Obesity fracture postmenopausal women meta-analysis cohort study |
url | https://www.tandfonline.com/doi/10.1080/07853890.2023.2203515 |
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