Desmopressin 120 mcg, 180 mcg, 240 mcg: The right treatment for the right patient
Background: The first-line drug therapy for patients with nocturnal enuresis (NE) associated with nocturnal polyuria and normal bladder function is desmopressin (dDAVP). Objective: To evaluate if increasing dose of oral desmopressin lyophilisate (MELT) can improve response rates to dDAVP and is usef...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2018-06-01
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| Series: | Archivio Italiano di Urologia e Andrologia |
| Subjects: | |
| Online Access: | https://www.pagepressjournals.org/index.php/aiua/article/view/7343 |
| _version_ | 1818342117738545152 |
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| author | Pietro Ferrara Ester Del Vescovo Francesca Ianniello Giulia Franceschini Luciana Romaniello Alberto Verrotti |
| author_facet | Pietro Ferrara Ester Del Vescovo Francesca Ianniello Giulia Franceschini Luciana Romaniello Alberto Verrotti |
| author_sort | Pietro Ferrara |
| collection | DOAJ |
| description | Background: The first-line drug therapy for patients with nocturnal enuresis (NE) associated with nocturnal polyuria and normal bladder function is desmopressin (dDAVP). Objective: To evaluate if increasing dose of oral desmopressin lyophilisate (MELT) can improve response rates to dDAVP and is useful in enuretic children.
Materials and methods: We enrolled a total of 260 children all diagnosed with NE. Enuretic children were treated with increasing MELT at a dose of 120, 180 and 240 mcg a day.
Results. We included in our study a total of 237 children, 164 males (69.2%) and 73 females (30.8%) aged between 5 and 18 years (mean age 10.32 ± 2.52 years). Of the 237 patients enrolled in the study and treated with MELT 120 mcg, a full response was achieved in 135 (56.9%). A partial response was achieved in 21 (8.9%) patients, therefore the dose was increased up to 180 mcg, with further improving symptoms (14.3%) or full response (9.5%), and up to 240 mcg, without usefulness.
Conclusions: MELT at the dose of 120 mcg resulted efficacy and safety; the increased dose up to 180 mcg resulted poorly efficacy; finally, the further increase up to 240 mcg did not improve the symptoms with the increased risk of side effects. |
| first_indexed | 2024-12-13T16:09:36Z |
| format | Article |
| id | doaj.art-b685ebcaebdf4297a924beaa1dcc3007 |
| institution | Directory Open Access Journal |
| issn | 1124-3562 2282-4197 |
| language | English |
| last_indexed | 2024-12-13T16:09:36Z |
| publishDate | 2018-06-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Archivio Italiano di Urologia e Andrologia |
| spelling | doaj.art-b685ebcaebdf4297a924beaa1dcc30072022-12-21T23:38:58ZengPAGEPress PublicationsArchivio Italiano di Urologia e Andrologia1124-35622282-41972018-06-0190212712910.4081/aiua.2018.2.1275778Desmopressin 120 mcg, 180 mcg, 240 mcg: The right treatment for the right patientPietro Ferrara0Ester Del Vescovo1Francesca Ianniello2Giulia Franceschini3Luciana Romaniello4Alberto Verrotti5Institute of Pediatrics, Catholic University Medical School, Rome; Campus Bio-Medico University, RomeCampus Bio-Medico University, RomeInstitute of Pediatrics, Catholic University Medical School, RomeCampus Bio-Medico University, RomeSan Carlo Hospital, PotenzaDepartment of Pediatrics, University of L’Aquila, L’AquilaBackground: The first-line drug therapy for patients with nocturnal enuresis (NE) associated with nocturnal polyuria and normal bladder function is desmopressin (dDAVP). Objective: To evaluate if increasing dose of oral desmopressin lyophilisate (MELT) can improve response rates to dDAVP and is useful in enuretic children. Materials and methods: We enrolled a total of 260 children all diagnosed with NE. Enuretic children were treated with increasing MELT at a dose of 120, 180 and 240 mcg a day. Results. We included in our study a total of 237 children, 164 males (69.2%) and 73 females (30.8%) aged between 5 and 18 years (mean age 10.32 ± 2.52 years). Of the 237 patients enrolled in the study and treated with MELT 120 mcg, a full response was achieved in 135 (56.9%). A partial response was achieved in 21 (8.9%) patients, therefore the dose was increased up to 180 mcg, with further improving symptoms (14.3%) or full response (9.5%), and up to 240 mcg, without usefulness. Conclusions: MELT at the dose of 120 mcg resulted efficacy and safety; the increased dose up to 180 mcg resulted poorly efficacy; finally, the further increase up to 240 mcg did not improve the symptoms with the increased risk of side effects.https://www.pagepressjournals.org/index.php/aiua/article/view/7343DesmopressinNocturnal enuresis |
| spellingShingle | Pietro Ferrara Ester Del Vescovo Francesca Ianniello Giulia Franceschini Luciana Romaniello Alberto Verrotti Desmopressin 120 mcg, 180 mcg, 240 mcg: The right treatment for the right patient Archivio Italiano di Urologia e Andrologia Desmopressin Nocturnal enuresis |
| title | Desmopressin 120 mcg, 180 mcg, 240 mcg: The right treatment for the right patient |
| title_full | Desmopressin 120 mcg, 180 mcg, 240 mcg: The right treatment for the right patient |
| title_fullStr | Desmopressin 120 mcg, 180 mcg, 240 mcg: The right treatment for the right patient |
| title_full_unstemmed | Desmopressin 120 mcg, 180 mcg, 240 mcg: The right treatment for the right patient |
| title_short | Desmopressin 120 mcg, 180 mcg, 240 mcg: The right treatment for the right patient |
| title_sort | desmopressin 120 mcg 180 mcg 240 mcg the right treatment for the right patient |
| topic | Desmopressin Nocturnal enuresis |
| url | https://www.pagepressjournals.org/index.php/aiua/article/view/7343 |
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