Rapid and Selective Crystallization of Acetaminophen using Metal-Assisted and Microwave-Accelerated Evaporative Crystallization
In this paper, we demonstrate the application of Metal-Assisted and Microwave-Accelerated Evaporative Crystallization (MA-MAEC) technique to rapid and selective crystallization of a small drug compound. i.e. acetaminophen. Subsequent characterization of the crystals by optical microscopy, powder X-r...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2012-03-01
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| Series: | Nano Biomedicine and Engineering |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.5101/nbe.v4i1.p35-40 |
| _version_ | 1797673468228009984 |
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| author | Muzaffer Mohammed Maleeha F Syed Mona J Bhatt Eugene J Hoffman Kadir Aslan |
| author_facet | Muzaffer Mohammed Maleeha F Syed Mona J Bhatt Eugene J Hoffman Kadir Aslan |
| author_sort | Muzaffer Mohammed |
| collection | DOAJ |
| description | In this paper, we demonstrate the application of Metal-Assisted and Microwave-Accelerated Evaporative Crystallization (MA-MAEC) technique to rapid and selective crystallization of a small drug compound. i.e. acetaminophen. Subsequent characterization of the crystals by optical microscopy, powder X-ray diffraction (PXRD) and Raman spectroscopy showed quantitatively selective growth of different crystal forms at various experimental conditions. Acetaminophen crystals were grown predominantly as Form Ⅰ (99%) on blank glass slides at room temperature. Form Ⅱ crystals with 39% purity grown on SIFs using microwave energy. |
| first_indexed | 2024-03-11T21:45:52Z |
| format | Article |
| id | doaj.art-b6868b04bef5446496269dd285732f4b |
| institution | Directory Open Access Journal |
| issn | 2150-5578 |
| language | English |
| last_indexed | 2024-03-11T21:45:52Z |
| publishDate | 2012-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Nano Biomedicine and Engineering |
| spelling | doaj.art-b6868b04bef5446496269dd285732f4b2023-09-26T10:12:40ZengTsinghua University PressNano Biomedicine and Engineering2150-55782012-03-0141354010.5101/nbe.v4i1.p35-40Rapid and Selective Crystallization of Acetaminophen using Metal-Assisted and Microwave-Accelerated Evaporative CrystallizationMuzaffer Mohammed0Maleeha F Syed1Mona J Bhatt2Eugene J Hoffman3Kadir Aslan4Morgan State University, Department of Chemistry, 1700 East Cold Spring Lane, Baltimore, MD 21251Morgan State University, Department of Chemistry, 1700 East Cold Spring Lane, Baltimore, MD 21251Morgan State University, Department of Chemistry, 1700 East Cold Spring Lane, Baltimore, MD 21251Morgan State University, Department of Physics, 1700 East Cold Spring Lane, Baltimore, MD 21251Morgan State University, Department of Chemistry, 1700 East Cold Spring Lane, Baltimore, MD 21251In this paper, we demonstrate the application of Metal-Assisted and Microwave-Accelerated Evaporative Crystallization (MA-MAEC) technique to rapid and selective crystallization of a small drug compound. i.e. acetaminophen. Subsequent characterization of the crystals by optical microscopy, powder X-ray diffraction (PXRD) and Raman spectroscopy showed quantitatively selective growth of different crystal forms at various experimental conditions. Acetaminophen crystals were grown predominantly as Form Ⅰ (99%) on blank glass slides at room temperature. Form Ⅱ crystals with 39% purity grown on SIFs using microwave energy.https://www.sciopen.com/article/10.5101/nbe.v4i1.p35-40metal-assisted and microwave-accelerated evaporative crystallizationcrystallizationacetaminophensilver nanoparticles |
| spellingShingle | Muzaffer Mohammed Maleeha F Syed Mona J Bhatt Eugene J Hoffman Kadir Aslan Rapid and Selective Crystallization of Acetaminophen using Metal-Assisted and Microwave-Accelerated Evaporative Crystallization Nano Biomedicine and Engineering metal-assisted and microwave-accelerated evaporative crystallization crystallization acetaminophen silver nanoparticles |
| title | Rapid and Selective Crystallization of Acetaminophen using Metal-Assisted and Microwave-Accelerated Evaporative Crystallization |
| title_full | Rapid and Selective Crystallization of Acetaminophen using Metal-Assisted and Microwave-Accelerated Evaporative Crystallization |
| title_fullStr | Rapid and Selective Crystallization of Acetaminophen using Metal-Assisted and Microwave-Accelerated Evaporative Crystallization |
| title_full_unstemmed | Rapid and Selective Crystallization of Acetaminophen using Metal-Assisted and Microwave-Accelerated Evaporative Crystallization |
| title_short | Rapid and Selective Crystallization of Acetaminophen using Metal-Assisted and Microwave-Accelerated Evaporative Crystallization |
| title_sort | rapid and selective crystallization of acetaminophen using metal assisted and microwave accelerated evaporative crystallization |
| topic | metal-assisted and microwave-accelerated evaporative crystallization crystallization acetaminophen silver nanoparticles |
| url | https://www.sciopen.com/article/10.5101/nbe.v4i1.p35-40 |
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