Tea consumption and risk of incident dementia: A prospective cohort study of 377 592 UK Biobank participants
Abstract As a widely consumed beverage, tea boasts diverse health benefits. Herein, we aimed to investigate the association between tea consumption and dementia risk. We conducted a prospective cohort study with 377 592 UK Biobank participants during a 9-year follow-up. Cox regression models adjuste...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2022-04-01
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| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-022-01923-z |
| _version_ | 1818009829716787200 |
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| author | He-Ying Hu Bang-Sheng Wu Ya-Nan Ou Ya-Hui Ma Yu-Yuan Huang Wei Cheng Lan Tan Jin-Tai Yu |
| author_facet | He-Ying Hu Bang-Sheng Wu Ya-Nan Ou Ya-Hui Ma Yu-Yuan Huang Wei Cheng Lan Tan Jin-Tai Yu |
| author_sort | He-Ying Hu |
| collection | DOAJ |
| description | Abstract As a widely consumed beverage, tea boasts diverse health benefits. Herein, we aimed to investigate the association between tea consumption and dementia risk. We conducted a prospective cohort study with 377 592 UK Biobank participants during a 9-year follow-up. Cox regression models adjusted for age, sex, ethnicity, Townsend deprivation index, education, body mass index, lifestyle factors, dietary factors and apolipoprotein E4 status were used to examine the association of tea consumption with dementia risk. Subgroup analyses stratified by age, sex and forms of dementia (Alzheimer’s disease [AD] and vascular dementia [VD]) were performed. Moreover, the restricted cubic splines were used to calculate the nonlinear relationship between daily dosage of tea and dementia risk. After adjustment for all covariates, tea drinkers were 16% (95% confidence interval: 8–23) less likely to develop dementia compared with non-drinkers. Moderate consumption (1–6 cups/day) of tea exerted significant protective effects. Subgroup analyses showed that mid-aged participants or males benefited more from tea consumption. Moreover, moderate drinkers had a 16–19% lower hazard of AD and a 25–29% lower hazard of VD. Furthermore, a U-shaped association between tea consumption and dementia risk was shown (P non-linearity = 7E−04), and the consumption of around three cups per day showed the strongest protective effect. Within 3 cups/day, drinking one extra cup of tea per day brought a 6% reduction of incidence. In conclusion, moderate consumption of tea was significantly associated with a reduced risk of dementia, suggesting that tea consumption could be a modifiable lifestyle factor for dementia. |
| first_indexed | 2024-04-14T05:47:53Z |
| format | Article |
| id | doaj.art-b687a2e218cf4d1fb8f657fb17765a1e |
| institution | Directory Open Access Journal |
| issn | 2158-3188 |
| language | English |
| last_indexed | 2024-04-14T05:47:53Z |
| publishDate | 2022-04-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Translational Psychiatry |
| spelling | doaj.art-b687a2e218cf4d1fb8f657fb17765a1e2022-12-22T02:09:13ZengNature Publishing GroupTranslational Psychiatry2158-31882022-04-011211910.1038/s41398-022-01923-zTea consumption and risk of incident dementia: A prospective cohort study of 377 592 UK Biobank participantsHe-Ying Hu0Bang-Sheng Wu1Ya-Nan Ou2Ya-Hui Ma3Yu-Yuan Huang4Wei Cheng5Lan Tan6Jin-Tai Yu7Department of Neurology, Qingdao Municipal Hospital, Qingdao UniversityDepartment of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan UniversityDepartment of Neurology, Qingdao Municipal Hospital, Qingdao UniversityDepartment of Neurology, Qingdao Municipal Hospital, Qingdao UniversityDepartment of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan UniversityInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan UniversityDepartment of Neurology, Qingdao Municipal Hospital, Qingdao UniversityDepartment of Neurology, Qingdao Municipal Hospital, Qingdao UniversityAbstract As a widely consumed beverage, tea boasts diverse health benefits. Herein, we aimed to investigate the association between tea consumption and dementia risk. We conducted a prospective cohort study with 377 592 UK Biobank participants during a 9-year follow-up. Cox regression models adjusted for age, sex, ethnicity, Townsend deprivation index, education, body mass index, lifestyle factors, dietary factors and apolipoprotein E4 status were used to examine the association of tea consumption with dementia risk. Subgroup analyses stratified by age, sex and forms of dementia (Alzheimer’s disease [AD] and vascular dementia [VD]) were performed. Moreover, the restricted cubic splines were used to calculate the nonlinear relationship between daily dosage of tea and dementia risk. After adjustment for all covariates, tea drinkers were 16% (95% confidence interval: 8–23) less likely to develop dementia compared with non-drinkers. Moderate consumption (1–6 cups/day) of tea exerted significant protective effects. Subgroup analyses showed that mid-aged participants or males benefited more from tea consumption. Moreover, moderate drinkers had a 16–19% lower hazard of AD and a 25–29% lower hazard of VD. Furthermore, a U-shaped association between tea consumption and dementia risk was shown (P non-linearity = 7E−04), and the consumption of around three cups per day showed the strongest protective effect. Within 3 cups/day, drinking one extra cup of tea per day brought a 6% reduction of incidence. In conclusion, moderate consumption of tea was significantly associated with a reduced risk of dementia, suggesting that tea consumption could be a modifiable lifestyle factor for dementia.https://doi.org/10.1038/s41398-022-01923-z |
| spellingShingle | He-Ying Hu Bang-Sheng Wu Ya-Nan Ou Ya-Hui Ma Yu-Yuan Huang Wei Cheng Lan Tan Jin-Tai Yu Tea consumption and risk of incident dementia: A prospective cohort study of 377 592 UK Biobank participants Translational Psychiatry |
| title | Tea consumption and risk of incident dementia: A prospective cohort study of 377 592 UK Biobank participants |
| title_full | Tea consumption and risk of incident dementia: A prospective cohort study of 377 592 UK Biobank participants |
| title_fullStr | Tea consumption and risk of incident dementia: A prospective cohort study of 377 592 UK Biobank participants |
| title_full_unstemmed | Tea consumption and risk of incident dementia: A prospective cohort study of 377 592 UK Biobank participants |
| title_short | Tea consumption and risk of incident dementia: A prospective cohort study of 377 592 UK Biobank participants |
| title_sort | tea consumption and risk of incident dementia a prospective cohort study of 377 592 uk biobank participants |
| url | https://doi.org/10.1038/s41398-022-01923-z |
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