Under Pressure: Mechanical Stress Management in the Nucleus
Cells are constantly adjusting to the mechanical properties of their surroundings, operating a complex mechanochemical feedback, which hinges on mechanotransduction mechanisms. Whereas adhesion structures have been shown to play a central role in mechanotransduction, it now emerges that the nucleus...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2016-06-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2073-4409/5/2/27 |
| _version_ | 1797726036361740288 |
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| author | Néjma Belaadi Julien Aureille Christophe Guilluy |
| author_facet | Néjma Belaadi Julien Aureille Christophe Guilluy |
| author_sort | Néjma Belaadi |
| collection | DOAJ |
| description | Cells are constantly adjusting to the mechanical properties of their surroundings, operating a complex mechanochemical feedback, which hinges on mechanotransduction mechanisms. Whereas adhesion structures have been shown to play a central role in mechanotransduction, it now emerges that the nucleus may act as a mechanosensitive structure. Here, we review recent advances demonstrating that mechanical stress emanating from the cytoskeleton can activate pathways in the nucleus which eventually impact both its structure and the transcriptional machinery. |
| first_indexed | 2024-03-12T10:40:01Z |
| format | Article |
| id | doaj.art-b68a5b1748374a9ca1466c4668f7c161 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T10:40:01Z |
| publishDate | 2016-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-b68a5b1748374a9ca1466c4668f7c1612023-09-02T08:13:51ZengMDPI AGCells2073-44092016-06-01522710.3390/cells5020027cells5020027Under Pressure: Mechanical Stress Management in the NucleusNéjma Belaadi0Julien Aureille1Christophe Guilluy2Institut National de la Santé et de la Recherche Médicale, UMR 1087, l’institut du thorax, CNRS, UMR 6291, Université de Nantes, 44000 Nantes, FranceInstitut National de la Santé et de la Recherche Médicale, UMR 1209, Institute for Advanced Biosciences, CNRS UMR 5309, Université Grenoble Alpes, 38041 Grenoble, FranceInstitut National de la Santé et de la Recherche Médicale, UMR 1209, Institute for Advanced Biosciences, CNRS UMR 5309, Université Grenoble Alpes, 38041 Grenoble, FranceCells are constantly adjusting to the mechanical properties of their surroundings, operating a complex mechanochemical feedback, which hinges on mechanotransduction mechanisms. Whereas adhesion structures have been shown to play a central role in mechanotransduction, it now emerges that the nucleus may act as a mechanosensitive structure. Here, we review recent advances demonstrating that mechanical stress emanating from the cytoskeleton can activate pathways in the nucleus which eventually impact both its structure and the transcriptional machinery.http://www.mdpi.com/2073-4409/5/2/27mechanotransductionnucleoskeletonlaminalaminLINCnucleusmechanical stress |
| spellingShingle | Néjma Belaadi Julien Aureille Christophe Guilluy Under Pressure: Mechanical Stress Management in the Nucleus Cells mechanotransduction nucleoskeleton lamina lamin LINC nucleus mechanical stress |
| title | Under Pressure: Mechanical Stress Management in the Nucleus |
| title_full | Under Pressure: Mechanical Stress Management in the Nucleus |
| title_fullStr | Under Pressure: Mechanical Stress Management in the Nucleus |
| title_full_unstemmed | Under Pressure: Mechanical Stress Management in the Nucleus |
| title_short | Under Pressure: Mechanical Stress Management in the Nucleus |
| title_sort | under pressure mechanical stress management in the nucleus |
| topic | mechanotransduction nucleoskeleton lamina lamin LINC nucleus mechanical stress |
| url | http://www.mdpi.com/2073-4409/5/2/27 |
| work_keys_str_mv | AT nejmabelaadi underpressuremechanicalstressmanagementinthenucleus AT julienaureille underpressuremechanicalstressmanagementinthenucleus AT christopheguilluy underpressuremechanicalstressmanagementinthenucleus |