Neuroprotective Properties of Xenon According to Experimental Studies
ABSTRACT. An increase in the number of patients with severe brain damage of various etiologies determines the need to improve neuroprotection technologies. The review is devoted to modern views on the mechanisms of brain protection, as well as the basic processes underlying damage to neurons. The ar...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department
2020-10-01
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| Series: | Неотложная медицинская помощь |
| Subjects: | |
| Online Access: | https://www.jnmp.ru/jour/article/view/908 |
| _version_ | 1826564754242535424 |
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| author | O. A. Grebenchikov I. V. Molchanov A. I. Shpichko A. K. Yevseyev A. K. Shabanov S. Z. Khusainov S. S. Petrikov |
| author_facet | O. A. Grebenchikov I. V. Molchanov A. I. Shpichko A. K. Yevseyev A. K. Shabanov S. Z. Khusainov S. S. Petrikov |
| author_sort | O. A. Grebenchikov |
| collection | DOAJ |
| description | ABSTRACT. An increase in the number of patients with severe brain damage of various etiologies determines the need to improve neuroprotection technologies. The review is devoted to modern views on the mechanisms of brain protection, as well as the basic processes underlying damage to neurons. The article discusses the results of the most important experimental studies in this area using inert xenon gas. The authors analyzed a number of works highlighting neurotective properties of the xenon inhalation anesthetic in studies performed in vitro and in vivo. The main mechanisms of neuronal death depending on the type of damage are shown, the points of application of the protective effect of xenon on the brain and the prospects for further research in this area are demonstrated in the article. |
| first_indexed | 2024-03-12T18:14:37Z |
| format | Article |
| id | doaj.art-b68d6a13e0a44792b75e7c73d8f487b0 |
| institution | Directory Open Access Journal |
| issn | 2223-9022 2541-8017 |
| language | Russian |
| last_indexed | 2025-03-14T10:24:53Z |
| publishDate | 2020-10-01 |
| publisher | Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department |
| record_format | Article |
| series | Неотложная медицинская помощь |
| spelling | doaj.art-b68d6a13e0a44792b75e7c73d8f487b02025-03-02T11:06:20ZrusSklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare DepartmentНеотложная медицинская помощь2223-90222541-80172020-10-0191859510.23934/2223-9022-2020-9-1-85-95576Neuroprotective Properties of Xenon According to Experimental StudiesO. A. Grebenchikov0I. V. Molchanov1A. I. Shpichko2A. K. Yevseyev3A. K. Shabanov4S. Z. Khusainov5S. S. Petrikov6Laboratory for Organ Protection in Critical Conditions, Federal Scientific and Clinical Center for Resuscitation and RehabilitationLaboratory for Organ Protection in Critical Conditions, Federal Scientific and Clinical Center for Resuscitation and RehabilitationLaboratory for Organ Protection in Critical Conditions, Federal Scientific and Clinical Center for Resuscitation and RehabilitationN.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health DepartmentLaboratory for Organ Protection in Critical Conditions, Federal Scientific and Clinical Center for Resuscitation and Rehabilitation; N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health DepartmentLaboratory for Organ Protection in Critical Conditions, Federal Scientific and Clinical Center for Resuscitation and Rehabilitation; N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health DepartmentN.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health DepartmentABSTRACT. An increase in the number of patients with severe brain damage of various etiologies determines the need to improve neuroprotection technologies. The review is devoted to modern views on the mechanisms of brain protection, as well as the basic processes underlying damage to neurons. The article discusses the results of the most important experimental studies in this area using inert xenon gas. The authors analyzed a number of works highlighting neurotective properties of the xenon inhalation anesthetic in studies performed in vitro and in vivo. The main mechanisms of neuronal death depending on the type of damage are shown, the points of application of the protective effect of xenon on the brain and the prospects for further research in this area are demonstrated in the article.https://www.jnmp.ru/jour/article/view/908xenonneuroprotectionstroketraumatic brain injurysubarachnoid hemorrhage |
| spellingShingle | O. A. Grebenchikov I. V. Molchanov A. I. Shpichko A. K. Yevseyev A. K. Shabanov S. Z. Khusainov S. S. Petrikov Neuroprotective Properties of Xenon According to Experimental Studies Неотложная медицинская помощь xenon neuroprotection stroke traumatic brain injury subarachnoid hemorrhage |
| title | Neuroprotective Properties of Xenon According to Experimental Studies |
| title_full | Neuroprotective Properties of Xenon According to Experimental Studies |
| title_fullStr | Neuroprotective Properties of Xenon According to Experimental Studies |
| title_full_unstemmed | Neuroprotective Properties of Xenon According to Experimental Studies |
| title_short | Neuroprotective Properties of Xenon According to Experimental Studies |
| title_sort | neuroprotective properties of xenon according to experimental studies |
| topic | xenon neuroprotection stroke traumatic brain injury subarachnoid hemorrhage |
| url | https://www.jnmp.ru/jour/article/view/908 |
| work_keys_str_mv | AT oagrebenchikov neuroprotectivepropertiesofxenonaccordingtoexperimentalstudies AT ivmolchanov neuroprotectivepropertiesofxenonaccordingtoexperimentalstudies AT aishpichko neuroprotectivepropertiesofxenonaccordingtoexperimentalstudies AT akyevseyev neuroprotectivepropertiesofxenonaccordingtoexperimentalstudies AT akshabanov neuroprotectivepropertiesofxenonaccordingtoexperimentalstudies AT szkhusainov neuroprotectivepropertiesofxenonaccordingtoexperimentalstudies AT sspetrikov neuroprotectivepropertiesofxenonaccordingtoexperimentalstudies |