ANTIOXIDANT EFFECT OF MILDRONATE IN PATIENTS AFTER CORONARY REVASCULARISATION
The study included 149 patients, aged 41–75 years, with Functional Class II-III stable angina, who underwent coronary artery bypass graft (CABG) surgery or percutaneous coronary intervention (PCI). Before the intervention, Group I (n=79) received standard therapy and mildronate (750 mg/d for 3 days,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2009-02-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1318 |
| Summary: | The study included 149 patients, aged 41–75 years, with Functional Class II-III stable angina, who underwent coronary artery bypass graft (CABG) surgery or percutaneous coronary intervention (PCI). Before the intervention, Group I (n=79) received standard therapy and mildronate (750 mg/d for 3 days, then 750 mg/d twice per week). Group II (n=70) did not receive any metabolic medications. Lipid peroxidation (LP) and antioxidant potential parameters were measured at baseline, 6 and 24 hours after the intervention in CABG patients; 10–15 days before, 2–3 days before and 1 day after the intervention in PCI participants. Pre-intervention mildronate therapy was associated with decreased blood levels of LP products, due to the activation of antioxidant enzymes – superoxide dismutase (SOD) and glutathione peroxidase (GP). |
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| ISSN: | 1560-4071 2618-7620 |