Extracellular Vesicles and Asthma—More Than Just a Co-Existence
Extracellular vesicles (EVs) are membranous structures, which are secreted by almost every cell type analyzed so far. In addition to their importance for cell-cell communication under physiological conditions, EVs are also released during pathogenesis and mechanistically contribute to this process....
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/9/4984 |
| _version_ | 1797534954609967104 |
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| author | Bilal Alashkar Alhamwe Daniel P. Potaczek Sarah Miethe Fahd Alhamdan Lukas Hintz Arslan Magomedov Holger Garn |
| author_facet | Bilal Alashkar Alhamwe Daniel P. Potaczek Sarah Miethe Fahd Alhamdan Lukas Hintz Arslan Magomedov Holger Garn |
| author_sort | Bilal Alashkar Alhamwe |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) are membranous structures, which are secreted by almost every cell type analyzed so far. In addition to their importance for cell-cell communication under physiological conditions, EVs are also released during pathogenesis and mechanistically contribute to this process. Here we summarize their functional relevance in asthma, one of the most common chronic non-communicable diseases. Asthma is a complex persistent inflammatory disorder of the airways characterized by reversible airflow obstruction and, from a long-term perspective, airway remodeling. Overall, mechanistic studies summarized here indicate the importance of different subtypes of EVs and their variable cargoes in the functioning of the pathways underlying asthma, and show some interesting potential for the development of future therapeutic interventions. Association studies in turn demonstrate a good diagnostic potential of EVs in asthma. |
| first_indexed | 2024-03-10T11:37:49Z |
| format | Article |
| id | doaj.art-b68dab9783b7462e95853f8379367fcf |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T11:37:49Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b68dab9783b7462e95853f8379367fcf2023-11-21T18:43:10ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-01229498410.3390/ijms22094984Extracellular Vesicles and Asthma—More Than Just a Co-ExistenceBilal Alashkar Alhamwe0Daniel P. Potaczek1Sarah Miethe2Fahd Alhamdan3Lukas Hintz4Arslan Magomedov5Holger Garn6Institute of Tumor Immunology, Clinic for Hematology, Oncology and Immunology, Center for Tumor Biology and Immunology, Philipps University Marburg, 35043 Marburg, GermanyTranslational Inflammation Research Division & Core Facility for Single Cell Multiomics, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center, Philipps University Marburg, 35043 Marburg, GermanyTranslational Inflammation Research Division & Core Facility for Single Cell Multiomics, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center, Philipps University Marburg, 35043 Marburg, GermanyTranslational Inflammation Research Division & Core Facility for Single Cell Multiomics, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center, Philipps University Marburg, 35043 Marburg, GermanyTranslational Inflammation Research Division & Core Facility for Single Cell Multiomics, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center, Philipps University Marburg, 35043 Marburg, GermanyInstitute of Tumor Immunology, Clinic for Hematology, Oncology and Immunology, Center for Tumor Biology and Immunology, Philipps University Marburg, 35043 Marburg, GermanyTranslational Inflammation Research Division & Core Facility for Single Cell Multiomics, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center, Philipps University Marburg, 35043 Marburg, GermanyExtracellular vesicles (EVs) are membranous structures, which are secreted by almost every cell type analyzed so far. In addition to their importance for cell-cell communication under physiological conditions, EVs are also released during pathogenesis and mechanistically contribute to this process. Here we summarize their functional relevance in asthma, one of the most common chronic non-communicable diseases. Asthma is a complex persistent inflammatory disorder of the airways characterized by reversible airflow obstruction and, from a long-term perspective, airway remodeling. Overall, mechanistic studies summarized here indicate the importance of different subtypes of EVs and their variable cargoes in the functioning of the pathways underlying asthma, and show some interesting potential for the development of future therapeutic interventions. Association studies in turn demonstrate a good diagnostic potential of EVs in asthma.https://www.mdpi.com/1422-0067/22/9/4984airwayallergyasthmaepigenetic(-s)exosomeextracellular vesicle (EV) |
| spellingShingle | Bilal Alashkar Alhamwe Daniel P. Potaczek Sarah Miethe Fahd Alhamdan Lukas Hintz Arslan Magomedov Holger Garn Extracellular Vesicles and Asthma—More Than Just a Co-Existence International Journal of Molecular Sciences airway allergy asthma epigenetic(-s) exosome extracellular vesicle (EV) |
| title | Extracellular Vesicles and Asthma—More Than Just a Co-Existence |
| title_full | Extracellular Vesicles and Asthma—More Than Just a Co-Existence |
| title_fullStr | Extracellular Vesicles and Asthma—More Than Just a Co-Existence |
| title_full_unstemmed | Extracellular Vesicles and Asthma—More Than Just a Co-Existence |
| title_short | Extracellular Vesicles and Asthma—More Than Just a Co-Existence |
| title_sort | extracellular vesicles and asthma more than just a co existence |
| topic | airway allergy asthma epigenetic(-s) exosome extracellular vesicle (EV) |
| url | https://www.mdpi.com/1422-0067/22/9/4984 |
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