Role of 11C Methionine Positron Emission Tomography (11CMETPET) for Surgery and Radiation Therapy Planning in Newly Diagnosed Glioblastoma Patients Enrolled into a Phase II Clinical Study
(1) Background: We investigated the role of [11C]-methionine PET in a cohort of newly diagnosed glioblastoma multiforme (GBM) patients to evaluate whether it could modify the extent of surgical resection and improve radiation therapy volume delineation. (2) Methods: Newly diagnosed GBM patients, age...
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MDPI AG
2021-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/11/2313 |
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| author | Federico Pessina Pierina Navarria Elena Clerici Luisa Bellu Andrea Franzini Davide Milani Matteo Simonelli Pasquale Persico Letterio S. Politi Alessandra Casarotti Bethania Fernandes Simone Olei Martina Sollini Arturo Chiti Marta Scorsetti |
| author_facet | Federico Pessina Pierina Navarria Elena Clerici Luisa Bellu Andrea Franzini Davide Milani Matteo Simonelli Pasquale Persico Letterio S. Politi Alessandra Casarotti Bethania Fernandes Simone Olei Martina Sollini Arturo Chiti Marta Scorsetti |
| author_sort | Federico Pessina |
| collection | DOAJ |
| description | (1) Background: We investigated the role of [11C]-methionine PET in a cohort of newly diagnosed glioblastoma multiforme (GBM) patients to evaluate whether it could modify the extent of surgical resection and improve radiation therapy volume delineation. (2) Methods: Newly diagnosed GBM patients, ages 18–70, with a Karnofsky performance scale (KPS) ≥ 70 with available MRI and [11C]-methionine PET were included. Patients were treated with different amounts of surgical resection followed by radio-chemotherapy. The role of [11C]-methionine PET in surgical and RT planning was analyzed. A threshold of SUVmax was searched. (3) Results: From August 2013 to April 2016, 93 patients were treated and included in this analysis. Residual tumor volume was detected in 63 cases on MRI and in 78 on [11C]-methionine PET, including 15 receiving gross total resection. The location of uptake was mainly observed in FLAIR abnormalities. [11C]-methionine uptake changed RT volume in 11% of patients. The presence of [11C]-methionine uptake in patients receiving GTR proved to influence survival (<i>p</i> = 0.029). The threshold of the SUVmax conditioning outcome was five. (4) Conclusions: [11C]-methionine PET allowed to detect areas at higher risk of recurrence located in FLAIR abnormalities in patients affected by GBM. A challenging issue is represented by integrating morphological and functional imaging to better define the extent of surgical resection to perform. |
| first_indexed | 2024-03-10T11:02:45Z |
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| id | doaj.art-b690d4894bd54297aa52e8e4d3a37d80 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T11:02:45Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-b690d4894bd54297aa52e8e4d3a37d802023-11-21T21:22:48ZengMDPI AGJournal of Clinical Medicine2077-03832021-05-011011231310.3390/jcm10112313Role of 11C Methionine Positron Emission Tomography (11CMETPET) for Surgery and Radiation Therapy Planning in Newly Diagnosed Glioblastoma Patients Enrolled into a Phase II Clinical StudyFederico Pessina0Pierina Navarria1Elena Clerici2Luisa Bellu3Andrea Franzini4Davide Milani5Matteo Simonelli6Pasquale Persico7Letterio S. Politi8Alessandra Casarotti9Bethania Fernandes10Simone Olei11Martina Sollini12Arturo Chiti13Marta Scorsetti14Neurosurgery Department, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyRadiotherapy and Radiosurgery Department, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyRadiotherapy and Radiosurgery Department, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyRadiotherapy and Radiosurgery Department, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyNeurosurgery Department, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyNeurosurgery Department, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 Milan, ItalyOncology and Hematology Department, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 Milan, ItalyNeurosurgery Department, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyPathology Department, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyNeurosurgery Department, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 Milan, ItalyDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 Milan, ItalyNeurosurgery Department, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy(1) Background: We investigated the role of [11C]-methionine PET in a cohort of newly diagnosed glioblastoma multiforme (GBM) patients to evaluate whether it could modify the extent of surgical resection and improve radiation therapy volume delineation. (2) Methods: Newly diagnosed GBM patients, ages 18–70, with a Karnofsky performance scale (KPS) ≥ 70 with available MRI and [11C]-methionine PET were included. Patients were treated with different amounts of surgical resection followed by radio-chemotherapy. The role of [11C]-methionine PET in surgical and RT planning was analyzed. A threshold of SUVmax was searched. (3) Results: From August 2013 to April 2016, 93 patients were treated and included in this analysis. Residual tumor volume was detected in 63 cases on MRI and in 78 on [11C]-methionine PET, including 15 receiving gross total resection. The location of uptake was mainly observed in FLAIR abnormalities. [11C]-methionine uptake changed RT volume in 11% of patients. The presence of [11C]-methionine uptake in patients receiving GTR proved to influence survival (<i>p</i> = 0.029). The threshold of the SUVmax conditioning outcome was five. (4) Conclusions: [11C]-methionine PET allowed to detect areas at higher risk of recurrence located in FLAIR abnormalities in patients affected by GBM. A challenging issue is represented by integrating morphological and functional imaging to better define the extent of surgical resection to perform.https://www.mdpi.com/2077-0383/10/11/2313newly diagnosed glioblastoma[11C]-methionine PETsurgeryradiation therapysupratotal resection |
| spellingShingle | Federico Pessina Pierina Navarria Elena Clerici Luisa Bellu Andrea Franzini Davide Milani Matteo Simonelli Pasquale Persico Letterio S. Politi Alessandra Casarotti Bethania Fernandes Simone Olei Martina Sollini Arturo Chiti Marta Scorsetti Role of 11C Methionine Positron Emission Tomography (11CMETPET) for Surgery and Radiation Therapy Planning in Newly Diagnosed Glioblastoma Patients Enrolled into a Phase II Clinical Study Journal of Clinical Medicine newly diagnosed glioblastoma [11C]-methionine PET surgery radiation therapy supratotal resection |
| title | Role of 11C Methionine Positron Emission Tomography (11CMETPET) for Surgery and Radiation Therapy Planning in Newly Diagnosed Glioblastoma Patients Enrolled into a Phase II Clinical Study |
| title_full | Role of 11C Methionine Positron Emission Tomography (11CMETPET) for Surgery and Radiation Therapy Planning in Newly Diagnosed Glioblastoma Patients Enrolled into a Phase II Clinical Study |
| title_fullStr | Role of 11C Methionine Positron Emission Tomography (11CMETPET) for Surgery and Radiation Therapy Planning in Newly Diagnosed Glioblastoma Patients Enrolled into a Phase II Clinical Study |
| title_full_unstemmed | Role of 11C Methionine Positron Emission Tomography (11CMETPET) for Surgery and Radiation Therapy Planning in Newly Diagnosed Glioblastoma Patients Enrolled into a Phase II Clinical Study |
| title_short | Role of 11C Methionine Positron Emission Tomography (11CMETPET) for Surgery and Radiation Therapy Planning in Newly Diagnosed Glioblastoma Patients Enrolled into a Phase II Clinical Study |
| title_sort | role of 11c methionine positron emission tomography 11cmetpet for surgery and radiation therapy planning in newly diagnosed glioblastoma patients enrolled into a phase ii clinical study |
| topic | newly diagnosed glioblastoma [11C]-methionine PET surgery radiation therapy supratotal resection |
| url | https://www.mdpi.com/2077-0383/10/11/2313 |
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