Evaluation of meropenem doses prescribed in an adult intensive care unit at a large hospital in Serra Gaúcha
Objective: To evaluate the conformity of dose and/or posology of meropenem prescribed in the setting of kidney impairment, otherwise to evaluate the microbiological profile of the germs isolated in those patients. In addition, to measure the extra costs of non-adjusted prescriptions. Method: This wo...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde
2022-12-01
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| Series: | Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde |
| Online Access: | https://rbfhss.org.br/sbrafh/article/view/873 |
| _version_ | 1797978379321868288 |
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| author | Fernando BOARO Ramone A. BERTUSSI |
| author_facet | Fernando BOARO Ramone A. BERTUSSI |
| author_sort | Fernando BOARO |
| collection | DOAJ |
| description | Objective: To evaluate the conformity of dose and/or posology of meropenem prescribed in the setting of kidney impairment, otherwise to evaluate the microbiological profile of the germs isolated in those patients. In addition, to measure the extra costs of non-adjusted prescriptions. Method: This work is a Drug Utilization Review. Were included charts of adult patients, of both sex, that had meropenem prescribed between 01/01/2021 and 06/30/2021, while admitted in the ICU regimen, in a large hospital in Serra Gaúcha. For dose analysis, UpToDate was used as guideline, prescriptions from patients on renal replacement therapy, as well as prescriptions from patients who did not have a creatinine result in the 24 hours prior to the prescription of meropenem, were excluded. Results: A total of 2044 prescriptions were evaluated, of which 667 were excluded because they did not meet the inclusion criteria. Of the 1377 prescriptions included, 1003 were considered adequate (73%) and 374 inadequate (27%). Of the doses considered inadequate, 54 were by underdose (14%) and 320 by overdose (86 %). The extra cost measured was US$1.835,21, equivalent to 993 vials of 500 mg. Microbiologically, there was a higher incidence of Gram-negatives: 81% (383/473). Of these, 54% resistant to meropenem (208/383), 5% (20/383) presumed sensitive, 3% (11/383) intrinsically resistant, and 38% (144/383) sensitive in vitro. Conclusion: The findings support the promotion of the service provided by the clinical pharmacist and stewardship programs, both for the promotion of health in intensive care and for the preservation of the financial health of a philanthropic institution. |
| first_indexed | 2024-04-11T05:22:03Z |
| format | Article |
| id | doaj.art-b6918c06786748d8a31548519bd472e4 |
| institution | Directory Open Access Journal |
| issn | 2179-5924 2316-7750 |
| language | English |
| last_indexed | 2024-04-11T05:22:03Z |
| publishDate | 2022-12-01 |
| publisher | Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde |
| record_format | Article |
| series | Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde |
| spelling | doaj.art-b6918c06786748d8a31548519bd472e42022-12-23T19:41:53ZengSociedade Brasileira de Farmácia Hospitalar e Serviços de SaúdeRevista Brasileira de Farmácia Hospitalar e Serviços de Saúde2179-59242316-77502022-12-0113487387310.30968/rbfhss.2022.134.08731256Evaluation of meropenem doses prescribed in an adult intensive care unit at a large hospital in Serra GaúchaFernando BOAROhttps://orcid.org/0000-0002-8943-4694Ramone A. BERTUSSIhttps://orcid.org/0000-0002-7151-9729Objective: To evaluate the conformity of dose and/or posology of meropenem prescribed in the setting of kidney impairment, otherwise to evaluate the microbiological profile of the germs isolated in those patients. In addition, to measure the extra costs of non-adjusted prescriptions. Method: This work is a Drug Utilization Review. Were included charts of adult patients, of both sex, that had meropenem prescribed between 01/01/2021 and 06/30/2021, while admitted in the ICU regimen, in a large hospital in Serra Gaúcha. For dose analysis, UpToDate was used as guideline, prescriptions from patients on renal replacement therapy, as well as prescriptions from patients who did not have a creatinine result in the 24 hours prior to the prescription of meropenem, were excluded. Results: A total of 2044 prescriptions were evaluated, of which 667 were excluded because they did not meet the inclusion criteria. Of the 1377 prescriptions included, 1003 were considered adequate (73%) and 374 inadequate (27%). Of the doses considered inadequate, 54 were by underdose (14%) and 320 by overdose (86 %). The extra cost measured was US$1.835,21, equivalent to 993 vials of 500 mg. Microbiologically, there was a higher incidence of Gram-negatives: 81% (383/473). Of these, 54% resistant to meropenem (208/383), 5% (20/383) presumed sensitive, 3% (11/383) intrinsically resistant, and 38% (144/383) sensitive in vitro. Conclusion: The findings support the promotion of the service provided by the clinical pharmacist and stewardship programs, both for the promotion of health in intensive care and for the preservation of the financial health of a philanthropic institution.https://rbfhss.org.br/sbrafh/article/view/873 |
| spellingShingle | Fernando BOARO Ramone A. BERTUSSI Evaluation of meropenem doses prescribed in an adult intensive care unit at a large hospital in Serra Gaúcha Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde |
| title | Evaluation of meropenem doses prescribed in an adult intensive care unit at a large hospital in Serra Gaúcha |
| title_full | Evaluation of meropenem doses prescribed in an adult intensive care unit at a large hospital in Serra Gaúcha |
| title_fullStr | Evaluation of meropenem doses prescribed in an adult intensive care unit at a large hospital in Serra Gaúcha |
| title_full_unstemmed | Evaluation of meropenem doses prescribed in an adult intensive care unit at a large hospital in Serra Gaúcha |
| title_short | Evaluation of meropenem doses prescribed in an adult intensive care unit at a large hospital in Serra Gaúcha |
| title_sort | evaluation of meropenem doses prescribed in an adult intensive care unit at a large hospital in serra gaucha |
| url | https://rbfhss.org.br/sbrafh/article/view/873 |
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