Wearable Label‐Free Optical Biodetectors: Progress and Perspectives
Biomarkers are the primary indicators of human health. Measurements traditionally rely on targeted binding and assays, which, in turn, rely on specific “labels” that define the biomarker or molecule of interest. While selective and specific, label‐based approaches limit the range of biomarkers a tec...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2021-02-01
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| Series: | Advanced Photonics Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/adpr.202000076 |
| _version_ | 1818897190003671040 |
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| author | Shanmuga Sundar Dhanabalan Sharath Sriram Sumeet Walia Sivanantha Raja Avaninathan Marcos Flores Carrasco Madhu Bhaskaran |
| author_facet | Shanmuga Sundar Dhanabalan Sharath Sriram Sumeet Walia Sivanantha Raja Avaninathan Marcos Flores Carrasco Madhu Bhaskaran |
| author_sort | Shanmuga Sundar Dhanabalan |
| collection | DOAJ |
| description | Biomarkers are the primary indicators of human health. Measurements traditionally rely on targeted binding and assays, which, in turn, rely on specific “labels” that define the biomarker or molecule of interest. While selective and specific, label‐based approaches limit the range of biomarkers a technology can detect. Technologies that can detect and analyze a broad range of biomarkers offer versatility, especially rapid repurposing for new targets. Optical technologies for label‐free biomarker sensing enable noninvasive, minimal‐contact, and wearable or point‐of‐care rapid diagnostic measurements. Herein, label‐free biomarker detection is reviewed with an emphasis on progress toward miniaturized and noninvasive wearable devices. Compact light‐emitting devices and optical detection technologies are presented, tailored for a large range of biomarkers, including recent advances in battery‐free devices. Label‐free detection is reusable, reagent‐free, and allows continuous long‐term monitoring. The potential for optical technologies for label‐free detection in terms of integration, device design, and future applications is summarized. |
| first_indexed | 2024-12-19T19:12:14Z |
| format | Article |
| id | doaj.art-b6929a3ba5ec4365b6013bd3a349b291 |
| institution | Directory Open Access Journal |
| issn | 2699-9293 |
| language | English |
| last_indexed | 2024-12-19T19:12:14Z |
| publishDate | 2021-02-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Photonics Research |
| spelling | doaj.art-b6929a3ba5ec4365b6013bd3a349b2912022-12-21T20:09:15ZengWiley-VCHAdvanced Photonics Research2699-92932021-02-0122n/an/a10.1002/adpr.202000076Wearable Label‐Free Optical Biodetectors: Progress and PerspectivesShanmuga Sundar Dhanabalan0Sharath Sriram1Sumeet Walia2Sivanantha Raja Avaninathan3Marcos Flores Carrasco4Madhu Bhaskaran5Functional Materials and Microsystems Research Group and the Micro Nano Research Facility RMIT University GPO Box 2476 Melbourne, Victoria 3001 AustraliaFunctional Materials and Microsystems Research Group and the Micro Nano Research Facility RMIT University GPO Box 2476 Melbourne, Victoria 3001 AustraliaFunctional Materials and Microsystems Research Group and the Micro Nano Research Facility RMIT University GPO Box 2476 Melbourne, Victoria 3001 AustraliaElectronics and Communication Engineering Department Alagappa Chettiar Government College of Engineering and Technology Karaikudi 630003 Tamilnadu, IndiaSurfaces and Nanomaterials Laboratory Faculty of Physical Science and Mathematics University of Chile Beauchef 850 Santiago ChileFunctional Materials and Microsystems Research Group and the Micro Nano Research Facility RMIT University GPO Box 2476 Melbourne, Victoria 3001 AustraliaBiomarkers are the primary indicators of human health. Measurements traditionally rely on targeted binding and assays, which, in turn, rely on specific “labels” that define the biomarker or molecule of interest. While selective and specific, label‐based approaches limit the range of biomarkers a technology can detect. Technologies that can detect and analyze a broad range of biomarkers offer versatility, especially rapid repurposing for new targets. Optical technologies for label‐free biomarker sensing enable noninvasive, minimal‐contact, and wearable or point‐of‐care rapid diagnostic measurements. Herein, label‐free biomarker detection is reviewed with an emphasis on progress toward miniaturized and noninvasive wearable devices. Compact light‐emitting devices and optical detection technologies are presented, tailored for a large range of biomarkers, including recent advances in battery‐free devices. Label‐free detection is reusable, reagent‐free, and allows continuous long‐term monitoring. The potential for optical technologies for label‐free detection in terms of integration, device design, and future applications is summarized.https://doi.org/10.1002/adpr.202000076biomarkersbiosensorslabel-freeoptical detectionoptical technologywearables |
| spellingShingle | Shanmuga Sundar Dhanabalan Sharath Sriram Sumeet Walia Sivanantha Raja Avaninathan Marcos Flores Carrasco Madhu Bhaskaran Wearable Label‐Free Optical Biodetectors: Progress and Perspectives Advanced Photonics Research biomarkers biosensors label-free optical detection optical technology wearables |
| title | Wearable Label‐Free Optical Biodetectors: Progress and Perspectives |
| title_full | Wearable Label‐Free Optical Biodetectors: Progress and Perspectives |
| title_fullStr | Wearable Label‐Free Optical Biodetectors: Progress and Perspectives |
| title_full_unstemmed | Wearable Label‐Free Optical Biodetectors: Progress and Perspectives |
| title_short | Wearable Label‐Free Optical Biodetectors: Progress and Perspectives |
| title_sort | wearable label free optical biodetectors progress and perspectives |
| topic | biomarkers biosensors label-free optical detection optical technology wearables |
| url | https://doi.org/10.1002/adpr.202000076 |
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