A Comparison of Three Different Treatment Regimens of HCV Infection In 295 Iraqi Patients
Background: Viral Hepatitis C infection is global public health problem throughout the world.Different treatment regimens are use which produce different rate of response affected by many factors. Objectives:To assess the efficacy of three different treatment regimens in 295 Iraqi patients infect...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2019-07-01
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| Series: | مجلة كلية الطب |
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| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/660 |
| Summary: | Background: Viral Hepatitis C infection is global public health problem throughout the world.Different treatment regimens are use which produce different rate of response affected by many factors.
Objectives:To assess the efficacy of three different treatment regimens in 295 Iraqi patients infected with chronic HCV .
Patients and methods: This is observational cohort study; in which 295 (133 male and 162 female) patients with chronic HCV infection were enrolled to the period between August 2015 to January 2017 from gastroenterology clinic of Baghdad teaching hospital and gastroenterology and hepatology teaching hospital. Baseline viral load and genotype were done and patients who submitted to treatment were followed by viral load at end of treatment and after 3 month of end of treatment.
Results: The majority of patients infected with chronic HCV achieve SVR(have undetected virus after three month after end of treatment)were of generic( sofosbuvir/ledipasvir) treatment group (51 out of 72 (70.8% ) followed by generic (Sofosbuvir with peg interferon/ribavirin)treatment group (68 out of 111 ;61.3%) followed by(peg interferon/ribavirin)treatment group(42 out of 86;48.8%).
Conclusions:
The best efficacy of treatment obtained with generic sofosbuvir/ledipasvir followed by sofosbuvir with peg interferon and ribavirin then peg interferon and ribavirin, the most responder genotype in Iraqi patient was genotype 4 and the less responder genotype was genotype 1b. |
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| ISSN: | 0041-9419 2410-8057 |