Brain somatic mutations observed in Alzheimer’s disease associated with aging and dysregulation of tau phosphorylation
The role of brain somatic mutations in neurodegenerative diseases such as Alzheimer’s disease (AD) is not well understood. Here the authors carry out high-depth exome sequencing ~500× on brain tissue from patients with AD and controls, and identify mutations in a number of genes that are known to co...
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Bibliographic Details
| Main Authors: |
Jun Sung Park,
Junehawk Lee,
Eun Sun Jung,
Myeong-Heui Kim,
Il Bin Kim,
Hyeonju Son,
Sangwoo Kim,
Sanghyeon Kim,
Young Mok Park,
Inhee Mook-Jung,
Seok Jong Yu,
Jeong Ho Lee |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2019-07-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-019-11000-7
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