Plasma free fatty acid transport during prolonged glucose consumption and its relationship to plasma triglyceride fatty acids in man
Plasma free fatty acid (FFA) transport in human subjects has been studied during the course of prolonged ingestion of different amounts of glucose. Compared with the fasting state, hypocaloric glucose intake resulted in marked suppression of net transport of FFA with no change in (fractional) turnov...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
1972-07-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520393822 |
| _version_ | 1818671941881430016 |
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| author | Philip J. Barter Paul J. Nestel |
| author_facet | Philip J. Barter Paul J. Nestel |
| author_sort | Philip J. Barter |
| collection | DOAJ |
| description | Plasma free fatty acid (FFA) transport in human subjects has been studied during the course of prolonged ingestion of different amounts of glucose. Compared with the fasting state, hypocaloric glucose intake resulted in marked suppression of net transport of FFA with no change in (fractional) turnover rate. There was no further suppression of net transport of FFA when the intake was increased to isocaloric or hypercaloric levels, but there was a significant increase in the (fractional) turnover rate, indicating an enhancement of clearance mechanisms. During the 20–24-hr period of fasting after isocaloric glucose consumption, the (fractional) turnover rate quickly fell to that found in the fasting individual, whereas net transport remained suppressed for much longer. This suggested that ingestion of glucose maintains an influence on lipolysis longer than on esterification. During this period of fasting after glucose administration, the contribution of plasma FFA to circulating triglyceride fatty acids increased with time and was positively and significantly correlated with the changes in the net transport of plasma FFA. |
| first_indexed | 2024-12-17T07:32:00Z |
| format | Article |
| id | doaj.art-b695aa52e1c04c26801268308fe74e6c |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-17T07:32:00Z |
| publishDate | 1972-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-b695aa52e1c04c26801268308fe74e6c2022-12-21T21:58:28ZengElsevierJournal of Lipid Research0022-22751972-07-01134483490Plasma free fatty acid transport during prolonged glucose consumption and its relationship to plasma triglyceride fatty acids in manPhilip J. Barter0Paul J. Nestel1Department of Clinical Science, The John Curtin School of Medical Research, The Australian National University, Canberra, A.C.T., Australia, 2601Department of Clinical Science, The John Curtin School of Medical Research, The Australian National University, Canberra, A.C.T., Australia, 2601Plasma free fatty acid (FFA) transport in human subjects has been studied during the course of prolonged ingestion of different amounts of glucose. Compared with the fasting state, hypocaloric glucose intake resulted in marked suppression of net transport of FFA with no change in (fractional) turnover rate. There was no further suppression of net transport of FFA when the intake was increased to isocaloric or hypercaloric levels, but there was a significant increase in the (fractional) turnover rate, indicating an enhancement of clearance mechanisms. During the 20–24-hr period of fasting after isocaloric glucose consumption, the (fractional) turnover rate quickly fell to that found in the fasting individual, whereas net transport remained suppressed for much longer. This suggested that ingestion of glucose maintains an influence on lipolysis longer than on esterification. During this period of fasting after glucose administration, the contribution of plasma FFA to circulating triglyceride fatty acids increased with time and was positively and significantly correlated with the changes in the net transport of plasma FFA.http://www.sciencedirect.com/science/article/pii/S0022227520393822caloric intakenet transportprecursors of plasma triglyceride fatty acids |
| spellingShingle | Philip J. Barter Paul J. Nestel Plasma free fatty acid transport during prolonged glucose consumption and its relationship to plasma triglyceride fatty acids in man Journal of Lipid Research caloric intake net transport precursors of plasma triglyceride fatty acids |
| title | Plasma free fatty acid transport during prolonged glucose consumption and its relationship to plasma triglyceride fatty acids in man |
| title_full | Plasma free fatty acid transport during prolonged glucose consumption and its relationship to plasma triglyceride fatty acids in man |
| title_fullStr | Plasma free fatty acid transport during prolonged glucose consumption and its relationship to plasma triglyceride fatty acids in man |
| title_full_unstemmed | Plasma free fatty acid transport during prolonged glucose consumption and its relationship to plasma triglyceride fatty acids in man |
| title_short | Plasma free fatty acid transport during prolonged glucose consumption and its relationship to plasma triglyceride fatty acids in man |
| title_sort | plasma free fatty acid transport during prolonged glucose consumption and its relationship to plasma triglyceride fatty acids in man |
| topic | caloric intake net transport precursors of plasma triglyceride fatty acids |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520393822 |
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