Immune checkpoint molecules: “new” kids on the block of skin photoimmunology
Ultraviolet radiation (UVR) is a prominent etiological factor of the pathogenesis of skin diseases such as squamous cell carcinoma and melanoma. Excessive exposure to the natural sources of UVR such as sunlight or artificially from tanning lamps has been linked to the increasing incidence of skin ca...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2021-01-01
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| Series: | Genes and Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304219301151 |
| _version_ | 1827267685870731264 |
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| author | Wei Wang Zhao-Hui Wu |
| author_facet | Wei Wang Zhao-Hui Wu |
| author_sort | Wei Wang |
| collection | DOAJ |
| description | Ultraviolet radiation (UVR) is a prominent etiological factor of the pathogenesis of skin diseases such as squamous cell carcinoma and melanoma. Excessive exposure to the natural sources of UVR such as sunlight or artificially from tanning lamps has been linked to the increasing incidence of skin cancers in the United States. Besides the skin inflammation, DNA damage and oncogenic mutation caused by UVR, UV exposure also plays a critical role in suppressing local and systemic immune responses which enable premalignant and cancer cells to escape immune surveillance. A variety of mechanisms have been reported to regulate the immune-suppressive effects of UVR. Here we discuss the current understanding of how UV modulates the local and systemic immunity, the recent progress in roles of immune checkpoint molecules in UVR-induced immune suppression, and how the crosstalk between the immune cells may shape the immune landscape of the skin upon UVR. |
| first_indexed | 2024-03-12T06:07:59Z |
| format | Article |
| id | doaj.art-b696c0b6330c4d4f9fc5831b43bd29b3 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2025-03-22T04:37:41Z |
| publishDate | 2021-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-b696c0b6330c4d4f9fc5831b43bd29b32024-04-28T00:28:49ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422021-01-018115Immune checkpoint molecules: “new” kids on the block of skin photoimmunologyWei Wang0Zhao-Hui Wu1Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, USA; Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN, USACorresponding author. University of Tennessee Health Science Center, 19 S. Manassas St., Memphis, TN, 38163, USA. Fax: +1 901 448 3910.; Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, USA; Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN, USA; Department of Radiation Oncology, USAUltraviolet radiation (UVR) is a prominent etiological factor of the pathogenesis of skin diseases such as squamous cell carcinoma and melanoma. Excessive exposure to the natural sources of UVR such as sunlight or artificially from tanning lamps has been linked to the increasing incidence of skin cancers in the United States. Besides the skin inflammation, DNA damage and oncogenic mutation caused by UVR, UV exposure also plays a critical role in suppressing local and systemic immune responses which enable premalignant and cancer cells to escape immune surveillance. A variety of mechanisms have been reported to regulate the immune-suppressive effects of UVR. Here we discuss the current understanding of how UV modulates the local and systemic immunity, the recent progress in roles of immune checkpoint molecules in UVR-induced immune suppression, and how the crosstalk between the immune cells may shape the immune landscape of the skin upon UVR.http://www.sciencedirect.com/science/article/pii/S2352304219301151 |
| spellingShingle | Wei Wang Zhao-Hui Wu Immune checkpoint molecules: “new” kids on the block of skin photoimmunology Genes and Diseases |
| title | Immune checkpoint molecules: “new” kids on the block of skin photoimmunology |
| title_full | Immune checkpoint molecules: “new” kids on the block of skin photoimmunology |
| title_fullStr | Immune checkpoint molecules: “new” kids on the block of skin photoimmunology |
| title_full_unstemmed | Immune checkpoint molecules: “new” kids on the block of skin photoimmunology |
| title_short | Immune checkpoint molecules: “new” kids on the block of skin photoimmunology |
| title_sort | immune checkpoint molecules new kids on the block of skin photoimmunology |
| url | http://www.sciencedirect.com/science/article/pii/S2352304219301151 |
| work_keys_str_mv | AT weiwang immunecheckpointmoleculesnewkidsontheblockofskinphotoimmunology AT zhaohuiwu immunecheckpointmoleculesnewkidsontheblockofskinphotoimmunology |