Characteristics of psychiatric patients with hypokalemia after yokukansan administration: A retrospective study
Abstract Aim Yokukansan is a Japanese herbal medicine used in psychiatry to treat behavioral and psychological symptoms of dementia and other psychiatric symptoms. However, the glycyrrhizic acid included in this medicine can cause pseudoaldosteronism and hypokalemia. We aimed to identify the risk fa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-03-01
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| Series: | PCN Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/pcn5.76 |
| _version_ | 1797853339324514304 |
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| author | Kazuya Yasuda Ryuichiro Takeda Ryuji Ikeda Yasushi Ishida |
| author_facet | Kazuya Yasuda Ryuichiro Takeda Ryuji Ikeda Yasushi Ishida |
| author_sort | Kazuya Yasuda |
| collection | DOAJ |
| description | Abstract Aim Yokukansan is a Japanese herbal medicine used in psychiatry to treat behavioral and psychological symptoms of dementia and other psychiatric symptoms. However, the glycyrrhizic acid included in this medicine can cause pseudoaldosteronism and hypokalemia. We aimed to identify the risk factors for hypokalemia due to yokukansan. Methods A retrospective cohort study was conducted on patients previously treated with yokukansan. The risk factors were determined by comparing the hypokalemia group with the non‐hypokalemia group for each parameter. Results This study included 304 patients who received yokukansan treatment between April 2009 and March 2019. We found that 17.4% (n = 53) of the patients experienced yokukansan‐induced hypokalemia. Risk factors detected as significantly different between patients with and without yokukansan‐associated hypokalemia were low serum potassium concentration before yokukansan administration, dose 7.5 g /day or more, and dementia. Hypokalemia occurred earlier in patients with low albumin, low potassium, and dementia. Conclusion It is necessary to pay attention to hypokalemia onset when administering yokukansan at 7.5 g or more to patients with low potassium levels and dementia. Our findings suggest that potassium levels must be checked early after yokukansan administration, especially in patients with low albumin, low potassium, and dementia. |
| first_indexed | 2024-04-09T19:49:01Z |
| format | Article |
| id | doaj.art-b696d5963bf0406cb25620102caaa103 |
| institution | Directory Open Access Journal |
| issn | 2769-2558 |
| language | English |
| last_indexed | 2024-04-09T19:49:01Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | PCN Reports |
| spelling | doaj.art-b696d5963bf0406cb25620102caaa1032023-04-03T11:55:56ZengWileyPCN Reports2769-25582023-03-0121n/an/a10.1002/pcn5.76Characteristics of psychiatric patients with hypokalemia after yokukansan administration: A retrospective studyKazuya Yasuda0Ryuichiro Takeda1Ryuji Ikeda2Yasushi Ishida3Department of Pharmacy University of Miyazaki Hospital Miyazaki JapanHealth Care and Safety Center University of Miyazaki Miyazaki JapanDepartment of Pharmacy University of Miyazaki Hospital Miyazaki JapanDepartment of Psychiatry, Faculty of Medicine University of Miyazaki Miyazaki JapanAbstract Aim Yokukansan is a Japanese herbal medicine used in psychiatry to treat behavioral and psychological symptoms of dementia and other psychiatric symptoms. However, the glycyrrhizic acid included in this medicine can cause pseudoaldosteronism and hypokalemia. We aimed to identify the risk factors for hypokalemia due to yokukansan. Methods A retrospective cohort study was conducted on patients previously treated with yokukansan. The risk factors were determined by comparing the hypokalemia group with the non‐hypokalemia group for each parameter. Results This study included 304 patients who received yokukansan treatment between April 2009 and March 2019. We found that 17.4% (n = 53) of the patients experienced yokukansan‐induced hypokalemia. Risk factors detected as significantly different between patients with and without yokukansan‐associated hypokalemia were low serum potassium concentration before yokukansan administration, dose 7.5 g /day or more, and dementia. Hypokalemia occurred earlier in patients with low albumin, low potassium, and dementia. Conclusion It is necessary to pay attention to hypokalemia onset when administering yokukansan at 7.5 g or more to patients with low potassium levels and dementia. Our findings suggest that potassium levels must be checked early after yokukansan administration, especially in patients with low albumin, low potassium, and dementia.https://doi.org/10.1002/pcn5.76dementiahypokalemiapsychiatric disordersrisk factorsyokukansan |
| spellingShingle | Kazuya Yasuda Ryuichiro Takeda Ryuji Ikeda Yasushi Ishida Characteristics of psychiatric patients with hypokalemia after yokukansan administration: A retrospective study PCN Reports dementia hypokalemia psychiatric disorders risk factors yokukansan |
| title | Characteristics of psychiatric patients with hypokalemia after yokukansan administration: A retrospective study |
| title_full | Characteristics of psychiatric patients with hypokalemia after yokukansan administration: A retrospective study |
| title_fullStr | Characteristics of psychiatric patients with hypokalemia after yokukansan administration: A retrospective study |
| title_full_unstemmed | Characteristics of psychiatric patients with hypokalemia after yokukansan administration: A retrospective study |
| title_short | Characteristics of psychiatric patients with hypokalemia after yokukansan administration: A retrospective study |
| title_sort | characteristics of psychiatric patients with hypokalemia after yokukansan administration a retrospective study |
| topic | dementia hypokalemia psychiatric disorders risk factors yokukansan |
| url | https://doi.org/10.1002/pcn5.76 |
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