Three Component One-Pot Synthesis and Antiproliferative Activity of New [1,2,4]Triazolo[4,3-<i>a</i>]pyrimidines

Three Component One-Pot Synthesis and Antiproliferative Activity of New [1,2,4]Triazolo[4,3-<i>a</i>]pyrimidines

A series of new [1,2,4]triazolo[4,3-a]pyrimidine derivatives was prepared using a one-pot three-component synthesis from 5-amino-1-phenyl-1<i>H</i>-1,2,4-triazoles, aromatic aldehydes and ethyl acetoacetate. The compound structures were confirmed by IR, <sup>1</sup>H-NMR, <...

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Bibliographic Details
Main Authors: Manel Ben Hassen, Dhouha Msalbi, Badr Jismy, Fares Elghali, Sami Aifa, Hassan Allouchi, Mohamed Abarbri, Fakher Chabchoub
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Molecules
Subjects:
multicomponent reaction
one-pot reaction
triazolopyrimidine
breast cancer
antitumoral
Online Access:https://www.mdpi.com/1420-3049/28/9/3917

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